HCSGD entry for GLI2

1. General information

Official gene symbolGLI2
Entrez ID2736
Gene full nameGLI family zinc finger 2
Other gene symbolsHPE9 THP1 THP2
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterIEA IMPbiological_process
GO:0001501Skeletal system developmentISSbiological_process
GO:0001649Osteoblast differentiationIDAbiological_process
GO:0001701In utero embryonic developmentIEAbiological_process
GO:0001822Kidney developmentIEA ISSbiological_process
GO:0002062Chondrocyte differentiationIEAbiological_process
GO:0002076Osteoblast developmentIEA ISSbiological_process
GO:0003682Chromatin bindingIEAmolecular_function
GO:0003700Sequence-specific DNA binding transcription factor activityIDA IEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005737CytoplasmIEAcellular_component
GO:0006351Transcription, DNA-templatedIEAbiological_process
GO:0006355Regulation of transcription, DNA-templatedIDAbiological_process
GO:0007224Smoothened signaling pathwayIDAbiological_process
GO:0007389Pattern specification processISSbiological_process
GO:0007411Axon guidanceIEA ISSbiological_process
GO:0007418Ventral midline developmentISSbiological_process
GO:0007442Hindgut morphogenesisIEA ISSbiological_process
GO:0007507Heart developmentIEA ISSbiological_process
GO:0008270Zinc ion bindingIDAmolecular_function
GO:0008283Cell proliferationIDA IEAbiological_process
GO:0008589Regulation of smoothened signaling pathwayIEAbiological_process
GO:0009612Response to mechanical stimulusIEAbiological_process
GO:0009913Epidermal cell differentiationIDAbiological_process
GO:0009954Proximal/distal pattern formationIEA ISSbiological_process
GO:0016020MembraneIEAcellular_component
GO:0016607Nuclear speckIEAcellular_component
GO:0021508Floor plate formationIEA ISSbiological_process
GO:0021513Spinal cord dorsal/ventral patterningISSbiological_process
GO:0021517Ventral spinal cord developmentISSbiological_process
GO:0021696Cerebellar cortex morphogenesisIEA ISSbiological_process
GO:0021775Smoothened signaling pathway involved in ventral spinal cord interneuron specificationIEA ISSbiological_process
GO:0021776Smoothened signaling pathway involved in spinal cord motor neuron cell fate specificationIEAbiological_process
GO:0021938Smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferationIEAbiological_process
GO:0021965Spinal cord ventral commissure morphogenesisIEA ISSbiological_process
GO:0021983Pituitary gland developmentIEA ISSbiological_process
GO:0030324Lung developmentIEA ISSbiological_process
GO:0030879Mammary gland developmentISSbiological_process
GO:0030902Hindbrain developmentISSbiological_process
GO:0031512Motile primary ciliumIEAcellular_component
GO:0032331Negative regulation of chondrocyte differentiationIEAbiological_process
GO:0033089Positive regulation of T cell differentiation in thymusISSbiological_process
GO:0035295Tube developmentISSbiological_process
GO:0042475Odontogenesis of dentin-containing toothIEA ISSbiological_process
GO:0042733Embryonic digit morphogenesisIEAbiological_process
GO:0043565Sequence-specific DNA bindingIDA IEAmolecular_function
GO:0044212Transcription regulatory region DNA bindingIEAmolecular_function
GO:0045666Positive regulation of neuron differentiationIEAbiological_process
GO:0045740Positive regulation of DNA replicationIDAbiological_process
GO:0045893Positive regulation of transcription, DNA-templatedIDAbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIDA IEAbiological_process
GO:0048566Embryonic digestive tract developmentIEA ISSbiological_process
GO:0048589Developmental growthIEA ISSbiological_process
GO:0048666Neuron developmentISSbiological_process
GO:0048754Branching morphogenesis of an epithelial tubeIEA ISSbiological_process
GO:0060032Notochord regressionIEAbiological_process
GO:0060322Head developmentIEAbiological_process
GO:0060513Prostatic bud formationIEAbiological_process
GO:0060603Mammary gland duct morphogenesisIEAbiological_process
GO:0060831Smoothened signaling pathway involved in dorsal/ventral neural tube patterningIEAbiological_process
GO:0071407Cellular response to organic cyclic compoundIEAbiological_process
GO:0090103Cochlea morphogenesisIEAbiological_process
GO:2001141Regulation of RNA biosynthetic processIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.99705059080.00747571900.99999024730.1729640598

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.3584149388
GSE13712_SHEARDown-0.1374349939
GSE13712_STATICDown-0.0827152599
GSE19018Down-0.2770651357
GSE19899_A1Down-0.5586437773
GSE19899_A2Down-1.2072909772
PubMed_21979375_A1Down-1.2276960818
PubMed_21979375_A2Down-1.0294353523
GSE35957Down-0.3123854567
GSE36640Down-0.2288074951
GSE54402Down-0.2766020575
GSE9593Down-0.2005882777
GSE43922Down-0.6403643217
GSE24585Down-0.1832709702
GSE37065Down-0.1264172469
GSE28863_A1Up0.1436946403
GSE28863_A2Up0.0019283937
GSE28863_A3Up0.0265672734
GSE28863_A4Down-0.1862923271
GSE48662Down-0.1641048332

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-1MIMAT0000416MIRT023940MicroarrayFunctional MTI (Weak)18668037
hsa-miR-26b-5pMIMAT0000083MIRT029923MicroarrayFunctional MTI (Weak)19088304
hsa-miR-31-5pMIMAT0000089MIRT049876CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

25754218Primary bovine aortic endothelial cells, exposed to the secretome of THP-1 monocyte-derived foam cells, were analysed for the induction of senescence
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