HCSGD entry for GHRHR

1. General information

Official gene symbolGHRHR
Entrez ID2692
Gene full namegrowth hormone releasing hormone receptor
Other gene symbolsGHRFR GRFR IGHD1B
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0004930G-protein coupled receptor activityICmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005637Nuclear inner membraneIDAcellular_component
GO:0005640Nuclear outer membraneIDAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005886Plasma membraneIDA IEA TAScellular_component
GO:0007165Signal transductionNASbiological_process
GO:0007186G-protein coupled receptor signaling pathwayNASbiological_process
GO:0007189Adenylate cyclase-activating G-protein coupled receptor signaling pathwayIDAbiological_process
GO:0007190Activation of adenylate cyclase activityIEAbiological_process
GO:0007595LactationIEAbiological_process
GO:0008150Biological_processNDbiological_process
GO:0008284Positive regulation of cell proliferationIDAbiological_process
GO:0008340Determination of adult lifespanIEAbiological_process
GO:0009986Cell surfaceIDAcellular_component
GO:0016021Integral component of membraneIDA NAScellular_component
GO:0016363Nuclear matrixIDAcellular_component
GO:0016520Growth hormone-releasing hormone receptor activityIMP NASmolecular_function
GO:0017046Peptide hormone bindingIPImolecular_function
GO:0019838Growth factor bindingIPImolecular_function
GO:0019933CAMP-mediated signalingIMPbiological_process
GO:0030104Water homeostasisIEAbiological_process
GO:0030141Secretory granuleIDAcellular_component
GO:0030252Growth hormone secretionIEAbiological_process
GO:0030819Positive regulation of cAMP biosynthetic processIDAbiological_process
GO:0032868Response to insulinIMPbiological_process
GO:0032869Cellular response to insulin stimulusIEAbiological_process
GO:0033143Regulation of intracellular steroid hormone receptor signaling pathwayIEAbiological_process
GO:0040018Positive regulation of multicellular organism growthIMPbiological_process
GO:0042445Hormone metabolic processIEAbiological_process
GO:0043568Positive regulation of insulin-like growth factor receptor signaling pathwayNASbiological_process
GO:0043627Response to estrogenIDAbiological_process
GO:0048469Cell maturationIEAbiological_process
GO:0048609Multicellular organismal reproductive processNASbiological_process
GO:0051246Regulation of protein metabolic processIEAbiological_process
GO:0051384Response to glucocorticoidIDAbiological_process
GO:0060124Positive regulation of growth hormone secretionNASbiological_process
GO:0060133Somatotropin secreting cell developmentIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.62027713990.88910640930.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0377885069
GSE13712_SHEARUp0.0099780957
GSE13712_STATICDown-0.0089333563
GSE19018Down-0.0015563938
GSE19899_A1Up0.1476259641
GSE19899_A2Up0.0402189327
PubMed_21979375_A1Up0.1671793847
PubMed_21979375_A2Down-0.0610356824
GSE35957Down-0.0044973802
GSE36640Down-0.0456251802
GSE54402Down-0.0299606271
GSE9593Down-0.0303581158
GSE43922Up0.0348162981
GSE24585Down-0.1011606318
GSE37065Up0.0318802786
GSE28863_A1Up0.0326193740
GSE28863_A2Up0.1979277052
GSE28863_A3Up0.3469069907
GSE28863_A4Up0.0991496312
GSE48662Down-0.0652805594

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

SermorelinDB00010 BTD00033 | BIOD00033
TesamorelinDB08869 -

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.