HCSGD entry for GHRHR

1. General information

Official gene symbol	GHRHR
Entrez ID	2692
Gene full name	growth hormone releasing hormone receptor
Other gene symbols	GHRFR GRFR IGHD1B
Links to Entrez Gene	Links to Entrez Gene

2. Neighbors in the network

This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID	GO term	Evidence	Category
GO:0004930	G-protein coupled receptor activity	IC	molecular_function
GO:0005515	Protein binding	IPI	molecular_function
GO:0005637	Nuclear inner membrane	IDA	cellular_component
GO:0005640	Nuclear outer membrane	IDA	cellular_component
GO:0005737	Cytoplasm	IDA	cellular_component
GO:0005886	Plasma membrane	IDA IEA TAS	cellular_component
GO:0007165	Signal transduction	NAS	biological_process
GO:0007186	G-protein coupled receptor signaling pathway	NAS	biological_process
GO:0007189	Adenylate cyclase-activating G-protein coupled receptor signaling pathway	IDA	biological_process
GO:0007190	Activation of adenylate cyclase activity	IEA	biological_process
GO:0007595	Lactation	IEA	biological_process
GO:0008150	Biological_process	ND	biological_process
GO:0008284	Positive regulation of cell proliferation	IDA	biological_process
GO:0008340	Determination of adult lifespan	IEA	biological_process
GO:0009986	Cell surface	IDA	cellular_component
GO:0016021	Integral component of membrane	IDA NAS	cellular_component
GO:0016363	Nuclear matrix	IDA	cellular_component
GO:0016520	Growth hormone-releasing hormone receptor activity	IMP NAS	molecular_function
GO:0017046	Peptide hormone binding	IPI	molecular_function
GO:0019838	Growth factor binding	IPI	molecular_function
GO:0019933	CAMP-mediated signaling	IMP	biological_process
GO:0030104	Water homeostasis	IEA	biological_process
GO:0030141	Secretory granule	IDA	cellular_component
GO:0030252	Growth hormone secretion	IEA	biological_process
GO:0030819	Positive regulation of cAMP biosynthetic process	IDA	biological_process
GO:0032868	Response to insulin	IMP	biological_process
GO:0032869	Cellular response to insulin stimulus	IEA	biological_process
GO:0033143	Regulation of intracellular steroid hormone receptor signaling pathway	IEA	biological_process
GO:0040018	Positive regulation of multicellular organism growth	IMP	biological_process
GO:0042445	Hormone metabolic process	IEA	biological_process
GO:0043568	Positive regulation of insulin-like growth factor receptor signaling pathway	NAS	biological_process
GO:0043627	Response to estrogen	IDA	biological_process
GO:0048469	Cell maturation	IEA	biological_process
GO:0048609	Multicellular organismal reproductive process	NAS	biological_process
GO:0051246	Regulation of protein metabolic process	IEA	biological_process
GO:0051384	Response to glucocorticoid	IDA	biological_process
GO:0060124	Positive regulation of growth hormone secretion	NAS	biological_process
GO:0060133	Somatotropin secreting cell development	IEA	biological_process

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4. Expression levels in datasets

Meta-analysis result

p-value up	p-value down	FDR up	FDR down
0.6202771399	0.8891064093	0.9999902473	1.0000000000

Individual experiment result
( "-" represent NA in the specific microarray platform )

Data source	Up or down	Log fold change
GSE11954	Down	-0.0377885069
GSE13712_SHEAR	Up	0.0099780957
GSE13712_STATIC	Down	-0.0089333563
GSE19018	Down	-0.0015563938
GSE19899_A1	Up	0.1476259641
GSE19899_A2	Up	0.0402189327
PubMed_21979375_A1	Up	0.1671793847
PubMed_21979375_A2	Down	-0.0610356824
GSE35957	Down	-0.0044973802
GSE36640	Down	-0.0456251802
GSE54402	Down	-0.0299606271
GSE9593	Down	-0.0303581158
GSE43922	Up	0.0348162981
GSE24585	Down	-0.1011606318
GSE37065	Up	0.0318802786
GSE28863_A1	Up	0.0326193740
GSE28863_A2	Up	0.1979277052
GSE28863_A3	Up	0.3469069907
GSE28863_A4	Up	0.0991496312
GSE48662	Down	-0.0652805594

5. Regulation relationships with compounds/drugs/microRNAs

Compounds

Not regulated by compounds

Drugs

Name	Drug	Accession number
Sermorelin	DB00010	BTD00033 \| BIOD00033
Tesamorelin	DB08869	-

MicroRNAs

mirTarBase

No target information from mirTarBase

mirRecord

No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.

Navigator

1.General information
2.Neighbors in the network
3.Gene Ontology Annotation
4.Expression levels
5.Regulation
6.Text-mining results

HCSGD entry for GHRHR

1. General information

2. Neighbors in the network

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

4. Expression levels in datasets

Meta-analysis result

Individual experiment result ( "-" represent NA in the specific microarray platform )

( "-" represent NA in the specific microarray platform )

5. Regulation relationships with compounds/drugs/microRNAs

Compounds

Drugs

Name

Drug

Accession number

MicroRNAs

mirTarBase

mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.

Navigator

Individual experiment result
( "-" represent NA in the specific microarray platform )