HCSGD entry for GATA6

1. General information

Official gene symbolGATA6
Entrez ID2627
Gene full nameGATA binding protein 6
Other gene symbols
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterIDAbiological_process
GO:0000979RNA polymerase II core promoter sequence-specific DNA bindingIEAmolecular_function
GO:0000981Sequence-specific DNA binding RNA polymerase II transcription factor activityIMPmolecular_function
GO:0001103RNA polymerase II repressing transcription factor bindingIEAmolecular_function
GO:0001701In utero embryonic developmentIEAbiological_process
GO:0001889Liver developmentIEAbiological_process
GO:0003148Outflow tract septum morphogenesisIMPbiological_process
GO:0003309Type B pancreatic cell differentiationIEAbiological_process
GO:0003310Pancreatic A cell differentiationIEAbiological_process
GO:0003682Chromatin bindingIEAmolecular_function
GO:0003700Sequence-specific DNA binding transcription factor activityIDAmolecular_function
GO:0003705RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0005667Transcription factor complexIEAcellular_component
GO:0006366Transcription from RNA polymerase II promoterIDAbiological_process
GO:0006644Phospholipid metabolic processIEAbiological_process
GO:0007493Endodermal cell fate determinationIEAbiological_process
GO:0007596Blood coagulationTASbiological_process
GO:0008134Transcription factor bindingIPImolecular_function
GO:0008270Zinc ion bindingIEAmolecular_function
GO:0008584Male gonad developmentIEPbiological_process
GO:0014898Cardiac muscle hypertrophy in response to stressIEAbiological_process
GO:0019901Protein kinase bindingIPImolecular_function
GO:0032911Negative regulation of transforming growth factor beta1 productionIMPbiological_process
GO:0032912Negative regulation of transforming growth factor beta2 productionIMPbiological_process
GO:0035239Tube morphogenesisIEAbiological_process
GO:0042493Response to drugIMPbiological_process
GO:0043066Negative regulation of apoptotic processIMPbiological_process
GO:0043627Response to estrogenIEAbiological_process
GO:0044212Transcription regulatory region DNA bindingIDAmolecular_function
GO:0045766Positive regulation of angiogenesisIDAbiological_process
GO:0045892Negative regulation of transcription, DNA-templatedIDAbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIDA IEAbiological_process
GO:0048645Organ formationIEAbiological_process
GO:0051145Smooth muscle cell differentiationIMPbiological_process
GO:0051891Positive regulation of cardioblast differentiationIEAbiological_process
GO:0055007Cardiac muscle cell differentiationIEAbiological_process
GO:0060045Positive regulation of cardiac muscle cell proliferationIEAbiological_process
GO:0060430Lung saccule developmentIEAbiological_process
GO:0060486Clara cell differentiationIEAbiological_process
GO:0060510Type II pneumocyte differentiationIEAbiological_process
GO:0060575Intestinal epithelial cell differentiationIDAbiological_process
GO:0060947Cardiac vascular smooth muscle cell differentiationIMPbiological_process
GO:0070848Response to growth factorIDAbiological_process
GO:0071158Positive regulation of cell cycle arrestIDAbiological_process
GO:0071371Cellular response to gonadotropin stimulusIEAbiological_process
GO:0071456Cellular response to hypoxiaIDAbiological_process
GO:0071773Cellular response to BMP stimulusIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.92844214510.01272529160.99999024730.2227859707

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.5461687075
GSE13712_SHEARUp0.1338286111
GSE13712_STATICUp0.1029547206
GSE19018Down-0.2382392501
GSE19899_A1Down-0.4407348980
GSE19899_A2Down-0.8549899738
PubMed_21979375_A1Down-0.2781757275
PubMed_21979375_A2Down-2.1162741196
GSE35957Up0.1880463153
GSE36640Down-0.1336969401
GSE54402Down-1.3664733737
GSE9593Down-0.2292946591
GSE43922Down-0.0499849261
GSE24585Down-0.0472761320
GSE37065Down-0.1181080539
GSE28863_A1Up0.0518092686
GSE28863_A2Down-0.0379354502
GSE28863_A3Up0.2627830706
GSE28863_A4Up0.0378460616
GSE48662Down-0.3070659923

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-181c-5pMIMAT0000258MIRT000234Luciferase reporter assayFunctional MTI19585654
hsa-miR-181b-5pMIMAT0000257MIRT000239Luciferase reporter assayFunctional MTI19585654
hsa-miR-181a-5pMIMAT0000256MIRT000244Luciferase reporter assayFunctional MTI19585654
hsa-miR-181a-5pMIMAT0000256MIRT000244MicroarrayFunctional MTI (Weak)17612493
hsa-miR-200a-3pMIMAT0000682MIRT004006MicroarrayFunctional MTI (Weak)17875710
hsa-miR-1MIMAT0000416MIRT005905qRT-PCRFunctional MTI (Weak)21169019
hsa-miR-375MIMAT0000728MIRT019691MicroarrayFunctional MTI (Weak)20215506
hsa-miR-128-3pMIMAT0000424MIRT021891MicroarrayFunctional MTI (Weak)17612493
hsa-miR-124-3pMIMAT0000422MIRT022233MicroarrayFunctional MTI (Weak)18668037
hsa-miR-98-5pMIMAT0000096MIRT027415MicroarrayFunctional MTI (Weak)19088304
hsa-miR-92b-3pMIMAT0003218MIRT040623CLASHFunctional MTI (Weak)23622248
hsa-miR-140-5pMIMAT0000431MIRT045826CLASHFunctional MTI (Weak)23622248
hsa-miR-183-5pMIMAT0000261MIRT047056CLASHFunctional MTI (Weak)23622248
hsa-miR-20a-5pMIMAT0000075MIRT050560CLASHFunctional MTI (Weak)23622248
hsa-let-7b-5pMIMAT0000063MIRT051882CLASHFunctional MTI (Weak)23622248
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    • mirRecord

MicroRNA name

mirBase ID

Target site number

MiRNA mature ID

Test method inter

MiRNA regulation site

Reporter target site

Pubmed ID

hsa-miR-181b-5pMIMAT00002571hsa-miR-181b{Western blot}{downregulation}19585654
hsa-miR-181a-5pMIMAT00002561hsa-miR-181a{Western blot}{downregulation}19585654
hsa-miR-181c-5pMIMAT00002581hsa-miR-181c{Western blot}{downregulation}19585654
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6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.