HCSGD entry for GATA6

1. General information

Official gene symbolGATA6
Entrez ID2627
Gene full nameGATA binding protein 6
Other gene symbols
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterIDAbiological_process
GO:0000979RNA polymerase II core promoter sequence-specific DNA bindingIEAmolecular_function
GO:0000981Sequence-specific DNA binding RNA polymerase II transcription factor activityIMPmolecular_function
GO:0001103RNA polymerase II repressing transcription factor bindingIEAmolecular_function
GO:0001701In utero embryonic developmentIEAbiological_process
GO:0001889Liver developmentIEAbiological_process
GO:0003148Outflow tract septum morphogenesisIMPbiological_process
GO:0003309Type B pancreatic cell differentiationIEAbiological_process
GO:0003310Pancreatic A cell differentiationIEAbiological_process
GO:0003682Chromatin bindingIEAmolecular_function
GO:0003700Sequence-specific DNA binding transcription factor activityIDAmolecular_function
GO:0003705RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0005667Transcription factor complexIEAcellular_component
GO:0006366Transcription from RNA polymerase II promoterIDAbiological_process
GO:0006644Phospholipid metabolic processIEAbiological_process
GO:0007493Endodermal cell fate determinationIEAbiological_process
GO:0007596Blood coagulationTASbiological_process
GO:0008134Transcription factor bindingIPImolecular_function
GO:0008270Zinc ion bindingIEAmolecular_function
GO:0008584Male gonad developmentIEPbiological_process
GO:0014898Cardiac muscle hypertrophy in response to stressIEAbiological_process
GO:0019901Protein kinase bindingIPImolecular_function
GO:0032911Negative regulation of transforming growth factor beta1 productionIMPbiological_process
GO:0032912Negative regulation of transforming growth factor beta2 productionIMPbiological_process
GO:0035239Tube morphogenesisIEAbiological_process
GO:0042493Response to drugIMPbiological_process
GO:0043066Negative regulation of apoptotic processIMPbiological_process
GO:0043627Response to estrogenIEAbiological_process
GO:0044212Transcription regulatory region DNA bindingIDAmolecular_function
GO:0045766Positive regulation of angiogenesisIDAbiological_process
GO:0045892Negative regulation of transcription, DNA-templatedIDAbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIDA IEAbiological_process
GO:0048645Organ formationIEAbiological_process
GO:0051145Smooth muscle cell differentiationIMPbiological_process
GO:0051891Positive regulation of cardioblast differentiationIEAbiological_process
GO:0055007Cardiac muscle cell differentiationIEAbiological_process
GO:0060045Positive regulation of cardiac muscle cell proliferationIEAbiological_process
GO:0060430Lung saccule developmentIEAbiological_process
GO:0060486Clara cell differentiationIEAbiological_process
GO:0060510Type II pneumocyte differentiationIEAbiological_process
GO:0060575Intestinal epithelial cell differentiationIDAbiological_process
GO:0060947Cardiac vascular smooth muscle cell differentiationIMPbiological_process
GO:0070848Response to growth factorIDAbiological_process
GO:0071158Positive regulation of cell cycle arrestIDAbiological_process
GO:0071371Cellular response to gonadotropin stimulusIEAbiological_process
GO:0071456Cellular response to hypoxiaIDAbiological_process
GO:0071773Cellular response to BMP stimulusIEAbiological_process
Entries Per Page
Displaying Page of

4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.92844214510.01272529160.99999024730.2227859707

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.5461687075
GSE13712_SHEARUp0.1338286111
GSE13712_STATICUp0.1029547206
GSE19018Down-0.2382392501
GSE19899_A1Down-0.4407348980
GSE19899_A2Down-0.8549899738
PubMed_21979375_A1Down-0.2781757275
PubMed_21979375_A2Down-2.1162741196
GSE35957Up0.1880463153
GSE36640Down-0.1336969401
GSE54402Down-1.3664733737
GSE9593Down-0.2292946591
GSE43922Down-0.0499849261
GSE24585Down-0.0472761320
GSE37065Down-0.1181080539
GSE28863_A1Up0.0518092686
GSE28863_A2Down-0.0379354502
GSE28863_A3Up0.2627830706
GSE28863_A4Up0.0378460616
GSE48662Down-0.3070659923

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-181c-5pMIMAT0000258MIRT000234Luciferase reporter assayFunctional MTI19585654
hsa-miR-181b-5pMIMAT0000257MIRT000239Luciferase reporter assayFunctional MTI19585654
hsa-miR-181a-5pMIMAT0000256MIRT000244Luciferase reporter assayFunctional MTI19585654
hsa-miR-181a-5pMIMAT0000256MIRT000244MicroarrayFunctional MTI (Weak)17612493
hsa-miR-200a-3pMIMAT0000682MIRT004006MicroarrayFunctional MTI (Weak)17875710
hsa-miR-1MIMAT0000416MIRT005905qRT-PCRFunctional MTI (Weak)21169019
hsa-miR-375MIMAT0000728MIRT019691MicroarrayFunctional MTI (Weak)20215506
hsa-miR-128-3pMIMAT0000424MIRT021891MicroarrayFunctional MTI (Weak)17612493
hsa-miR-124-3pMIMAT0000422MIRT022233MicroarrayFunctional MTI (Weak)18668037
hsa-miR-98-5pMIMAT0000096MIRT027415MicroarrayFunctional MTI (Weak)19088304
hsa-miR-92b-3pMIMAT0003218MIRT040623CLASHFunctional MTI (Weak)23622248
hsa-miR-140-5pMIMAT0000431MIRT045826CLASHFunctional MTI (Weak)23622248
hsa-miR-183-5pMIMAT0000261MIRT047056CLASHFunctional MTI (Weak)23622248
hsa-miR-20a-5pMIMAT0000075MIRT050560CLASHFunctional MTI (Weak)23622248
hsa-let-7b-5pMIMAT0000063MIRT051882CLASHFunctional MTI (Weak)23622248
Entries Per Page
Displaying Page of
  • mirRecord

MicroRNA name

mirBase ID

Target site number

MiRNA mature ID

Test method inter

MiRNA regulation site

Reporter target site

Pubmed ID

hsa-miR-181b-5pMIMAT00002571hsa-miR-181b{Western blot}{downregulation}19585654
hsa-miR-181a-5pMIMAT00002561hsa-miR-181a{Western blot}{downregulation}19585654
hsa-miR-181c-5pMIMAT00002581hsa-miR-181c{Western blot}{downregulation}19585654
Entries Per Page
Displaying Page of

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.