HCSGD entry for BLOC1S6
1. General information
| Official gene symbol | BLOC1S6 |
|---|---|
| Entrez ID | 26258 |
| Gene full name | biogenesis of lysosomal organelles complex-1, subunit 6, pallidin |
| Other gene symbols | BLOS6 HPS9 PA PALLID PLDN |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005768 | Endosome | IEA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006892 | Post-Golgi vesicle-mediated transport | TAS | biological_process |
| GO:0007596 | Blood coagulation | IEA | biological_process |
| GO:0008089 | Anterograde axon cargo transport | IEA ISS | biological_process |
| GO:0012505 | Endomembrane system | IEA | cellular_component |
| GO:0016081 | Synaptic vesicle docking involved in exocytosis | NAS | biological_process |
| GO:0019898 | Extrinsic component of membrane | IDA | cellular_component |
| GO:0019905 | Syntaxin binding | TAS | molecular_function |
| GO:0030133 | Transport vesicle | IDA | cellular_component |
| GO:0030318 | Melanocyte differentiation | IEA | biological_process |
| GO:0031083 | BLOC-1 complex | IDA | cellular_component |
| GO:0031175 | Neuron projection development | IEA ISS | biological_process |
| GO:0031201 | SNARE complex | IDA | cellular_component |
| GO:0032402 | Melanosome transport | IDA | biological_process |
| GO:0032438 | Melanosome organization | NAS | biological_process |
| GO:0032816 | Positive regulation of natural killer cell activation | IEA | biological_process |
| GO:0033299 | Secretion of lysosomal enzymes | IEA | biological_process |
| GO:0035646 | Endosome to melanosome transport | IDA | biological_process |
| GO:0042802 | Identical protein binding | IPI | molecular_function |
| GO:0042803 | Protein homodimerization activity | IDA IPI | molecular_function |
| GO:0048490 | Anterograde synaptic vesicle transport | IEA ISS | biological_process |
| GO:0050942 | Positive regulation of pigment cell differentiation | IDA | biological_process |
| GO:0051015 | Actin filament binding | IDA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.8454861403 | 0.2140842863 | 0.9999902473 | 0.8933971623 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0823728092 |
| GSE13712_SHEAR | Up | 0.0294468459 |
| GSE13712_STATIC | Down | -0.0064461853 |
| GSE19018 | Up | 0.1992348335 |
| GSE19899_A1 | Down | -0.3287992837 |
| GSE19899_A2 | Down | -0.3979070679 |
| PubMed_21979375_A1 | Down | -0.3378658366 |
| PubMed_21979375_A2 | Down | -0.2047782756 |
| GSE35957 | Up | 0.1485188091 |
| GSE36640 | Down | -0.0492140737 |
| GSE54402 | Up | 0.0379375234 |
| GSE9593 | Up | 0.3241329621 |
| GSE43922 | Down | -0.2834811606 |
| GSE24585 | Down | -0.0286403714 |
| GSE37065 | Up | 0.0828889849 |
| GSE28863_A1 | Down | -0.2690761331 |
| GSE28863_A2 | Up | 0.0776852214 |
| GSE28863_A3 | Down | -0.5019151212 |
| GSE28863_A4 | Up | 0.2342704807 |
| GSE48662 | Down | -0.1934875893 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-124-3p | MIMAT0000422 | MIRT002614 | Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-124-3p | MIMAT0000422 | MIRT002614 | Microarray | Functional MTI (Weak) | 15685193 |
| hsa-miR-30b-5p | MIMAT0000420 | MIRT023412 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-101-3p | MIMAT0000099 | MIRT027360 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-484 | MIMAT0002174 | MIRT042100 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-3176 | MIMAT0015053 | MIRT052798 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
