HCSGD entry for GATA3

1. General information

Official gene symbolGATA3
Entrez ID2625
Gene full nameGATA binding protein 3
Other gene symbolsHDR HDRS
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000790Nuclear chromatinIDAcellular_component
GO:0000976Transcription regulatory region sequence-specific DNA bindingIDAmolecular_function
GO:0000979RNA polymerase II core promoter sequence-specific DNA bindingIEAmolecular_function
GO:0000987Core promoter proximal region sequence-specific DNA bindingIDAmolecular_function
GO:0001046Core promoter sequence-specific DNA bindingIDAmolecular_function
GO:0001071Nucleic acid binding transcription factor activityIDA IMPmolecular_function
GO:0001077RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptionIEAmolecular_function
GO:0001078RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcriptionIMPmolecular_function
GO:0001158Enhancer sequence-specific DNA bindingIEAmolecular_function
GO:0001701In utero embryonic developmentIEAbiological_process
GO:0001709Cell fate determinationISSbiological_process
GO:0001764Neuron migrationIEAbiological_process
GO:0001806Type IV hypersensitivityIEAbiological_process
GO:0001822Kidney developmentIMPbiological_process
GO:0001823Mesonephros developmentISSbiological_process
GO:0002088Lens development in camera-type eyeIEAbiological_process
GO:0002572Pro-T cell differentiationIEAbiological_process
GO:0003180Aortic valve morphogenesisISSbiological_process
GO:0003215Cardiac right ventricle morphogenesisISSbiological_process
GO:0003281Ventricular septum developmentISSbiological_process
GO:0003677DNA bindingTASmolecular_function
GO:0003700Sequence-specific DNA binding transcription factor activityTASmolecular_function
GO:0003713Transcription coactivator activityIDAmolecular_function
GO:0005134Interleukin-2 receptor bindingIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0005730NucleolusIDAcellular_component
GO:0006366Transcription from RNA polymerase II promoterTASbiological_process
GO:0006952Defense responseTASbiological_process
GO:0006959Humoral immune responseIEAbiological_process
GO:0007165Signal transductionISSbiological_process
GO:0007411Axon guidanceIEAbiological_process
GO:0007596Blood coagulationTASbiological_process
GO:0008134Transcription factor bindingIPImolecular_function
GO:0008270Zinc ion bindingIEAmolecular_function
GO:0008285Negative regulation of cell proliferationISSbiological_process
GO:0008584Male gonad developmentISSbiological_process
GO:0009615Response to virusIEPbiological_process
GO:0009653Anatomical structure morphogenesisTASbiological_process
GO:0009791Post-embryonic developmentIEAbiological_process
GO:0009967Positive regulation of signal transductionIMPbiological_process
GO:0010332Response to gamma radiationIEAbiological_process
GO:0010595Positive regulation of endothelial cell migrationIMPbiological_process
GO:0014065Phosphatidylinositol 3-kinase signalingISSbiological_process
GO:0030218Erythrocyte differentiationIEAbiological_process
GO:0031929TOR signalingISSbiological_process
GO:0032689Negative regulation of interferon-gamma productionIEAbiological_process
GO:0032703Negative regulation of interleukin-2 productionIEAbiological_process
GO:0032736Positive regulation of interleukin-13 productionIEAbiological_process
GO:0032753Positive regulation of interleukin-4 productionISSbiological_process
GO:0032754Positive regulation of interleukin-5 productionIEAbiological_process
GO:0033600Negative regulation of mammary gland epithelial cell proliferationIDAbiological_process
GO:0035162Embryonic hemopoiesisIEAbiological_process
GO:0035457Cellular response to interferon-alphaIEPbiological_process
GO:0035799Ureter maturationIEAbiological_process
GO:0035898Parathyroid hormone secretionIEAbiological_process
GO:0042035Regulation of cytokine biosynthetic processISSbiological_process
GO:0042421Norepinephrine biosynthetic processISSbiological_process
GO:0042472Inner ear morphogenesisIEAbiological_process
GO:0042493Response to drugIEAbiological_process
GO:0043370Regulation of CD4-positive, alpha-beta T cell differentiationIEAbiological_process
GO:0043523Regulation of neuron apoptotic processIEAbiological_process
GO:0043583Ear developmentIMPbiological_process
GO:0043627Response to estrogenIEPbiological_process
GO:0044212Transcription regulatory region DNA bindingIDAmolecular_function
GO:0045061Thymic T cell selectionIEAbiological_process
GO:0045064T-helper 2 cell differentiationIEAbiological_process
GO:0045471Response to ethanolIEAbiological_process
GO:0045582Positive regulation of T cell differentiationISSbiological_process
GO:0045599Negative regulation of fat cell differentiationIMPbiological_process
GO:0045786Negative regulation of cell cycleIMPbiological_process
GO:0045892Negative regulation of transcription, DNA-templatedIMPbiological_process
GO:0045893Positive regulation of transcription, DNA-templatedIDA IMP ISSbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIDA IMP ISSbiological_process
GO:0046983Protein dimerization activityIEAmolecular_function
GO:0048469Cell maturationIEAbiological_process
GO:0048485Sympathetic nervous system developmentISSbiological_process
GO:0048538Thymus developmentIEAbiological_process
GO:0048589Developmental growthIEAbiological_process
GO:0048646Anatomical structure formation involved in morphogenesisISSbiological_process
GO:0050728Negative regulation of inflammatory responseIMPbiological_process
GO:0050852T cell receptor signaling pathwayISSbiological_process
GO:0051569Regulation of histone H3-K4 methylationIEAbiological_process
GO:0051897Positive regulation of protein kinase B signalingIMPbiological_process
GO:0060017Parathyroid gland developmentIEAbiological_process
GO:0060037Pharyngeal system developmentISSbiological_process
GO:0060065Uterus developmentISSbiological_process
GO:0060231Mesenchymal to epithelial transitionIDAbiological_process
GO:0060374Mast cell differentiationIEAbiological_process
GO:0060676Ureteric bud formationISSbiological_process
GO:0061085Regulation of histone H3-K27 methylationIEAbiological_process
GO:0061290Canonical Wnt signaling pathway involved in metanephric kidney developmentISSbiological_process
GO:0070888E-box bindingIDAmolecular_function
GO:0071353Cellular response to interleukin-4IEPbiological_process
GO:0071356Cellular response to tumor necrosis factorIEPbiological_process
GO:0071599Otic vesicle developmentIEAbiological_process
GO:0071773Cellular response to BMP stimulusIEAbiological_process
GO:0071837HMG box domain bindingIPImolecular_function
GO:0072107Positive regulation of ureteric bud formationISSbiological_process
GO:0072178Nephric duct morphogenesisISSbiological_process
GO:0072179Nephric duct formationISSbiological_process
GO:0072182Regulation of nephron tubule epithelial cell differentiationISSbiological_process
GO:0072602Interleukin-4 secretionIEAbiological_process
GO:0072643Interferon-gamma secretionIEAbiological_process
GO:0072676Lymphocyte migrationIDAbiological_process
GO:2000114Regulation of establishment of cell polarityIEAbiological_process
GO:2000146Negative regulation of cell motilityIMPbiological_process
GO:2000352Negative regulation of endothelial cell apoptotic processIMPbiological_process
GO:2000607Negative regulation of cell proliferation involved in mesonephros developmentISSbiological_process
GO:2000611Positive regulation of thyroid hormone generationIMPbiological_process
GO:2000664Positive regulation of interleukin-5 secretionIDAbiological_process
GO:2000667Positive regulation of interleukin-13 secretionIDA IMPbiological_process
GO:2000679Positive regulation of transcription regulatory region DNA bindingIMPbiological_process
GO:2000683Regulation of cellular response to X-rayIMPbiological_process
GO:2000703Negative regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formationISSbiological_process
GO:2000734Negative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formationISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.79497519470.24887641050.99999024730.9588225995

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0172057640
GSE13712_SHEARDown-1.1031596677
GSE13712_STATICDown-1.3272379769
GSE19018Up0.0895606191
GSE19899_A1Up0.1210993863
GSE19899_A2Down-0.1108506281
PubMed_21979375_A1Down-0.0328726565
PubMed_21979375_A2Up0.0079085973
GSE35957Up0.0490578788
GSE36640Up0.8973060486
GSE54402Down-0.0730384690
GSE9593Down-0.0027252273
GSE43922Down-0.0373240611
GSE24585Up0.0615126165
GSE37065Down-0.0515267764
GSE28863_A1Down-0.1381833156
GSE28863_A2Down-0.0243770541
GSE28863_A3Up0.3429324902
GSE28863_A4Up0.0713896115
GSE48662Down-0.0946792399

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-132-3pMIMAT0000426MIRT021783MicroarrayFunctional MTI (Weak)17612493
hsa-miR-1MIMAT0000416MIRT024016MicroarrayFunctional MTI (Weak)18668037
hsa-miR-92a-3pMIMAT0000092MIRT049754CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.