HCSGD entry for GATA3

1. General information

Official gene symbolGATA3
Entrez ID2625
Gene full nameGATA binding protein 3
Other gene symbolsHDR HDRS
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000790Nuclear chromatinIDAcellular_component
GO:0000976Transcription regulatory region sequence-specific DNA bindingIDAmolecular_function
GO:0000979RNA polymerase II core promoter sequence-specific DNA bindingIEAmolecular_function
GO:0000987Core promoter proximal region sequence-specific DNA bindingIDAmolecular_function
GO:0001046Core promoter sequence-specific DNA bindingIDAmolecular_function
GO:0001071Nucleic acid binding transcription factor activityIDA IMPmolecular_function
GO:0001077RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptionIEAmolecular_function
GO:0001078RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcriptionIMPmolecular_function
GO:0001158Enhancer sequence-specific DNA bindingIEAmolecular_function
GO:0001701In utero embryonic developmentIEAbiological_process
GO:0001709Cell fate determinationISSbiological_process
GO:0001764Neuron migrationIEAbiological_process
GO:0001806Type IV hypersensitivityIEAbiological_process
GO:0001822Kidney developmentIMPbiological_process
GO:0001823Mesonephros developmentISSbiological_process
GO:0002088Lens development in camera-type eyeIEAbiological_process
GO:0002572Pro-T cell differentiationIEAbiological_process
GO:0003180Aortic valve morphogenesisISSbiological_process
GO:0003215Cardiac right ventricle morphogenesisISSbiological_process
GO:0003281Ventricular septum developmentISSbiological_process
GO:0003677DNA bindingTASmolecular_function
GO:0003700Sequence-specific DNA binding transcription factor activityTASmolecular_function
GO:0003713Transcription coactivator activityIDAmolecular_function
GO:0005134Interleukin-2 receptor bindingIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0005730NucleolusIDAcellular_component
GO:0006366Transcription from RNA polymerase II promoterTASbiological_process
GO:0006952Defense responseTASbiological_process
GO:0006959Humoral immune responseIEAbiological_process
GO:0007165Signal transductionISSbiological_process
GO:0007411Axon guidanceIEAbiological_process
GO:0007596Blood coagulationTASbiological_process
GO:0008134Transcription factor bindingIPImolecular_function
GO:0008270Zinc ion bindingIEAmolecular_function
GO:0008285Negative regulation of cell proliferationISSbiological_process
GO:0008584Male gonad developmentISSbiological_process
GO:0009615Response to virusIEPbiological_process
GO:0009653Anatomical structure morphogenesisTASbiological_process
GO:0009791Post-embryonic developmentIEAbiological_process
GO:0009967Positive regulation of signal transductionIMPbiological_process
GO:0010332Response to gamma radiationIEAbiological_process
GO:0010595Positive regulation of endothelial cell migrationIMPbiological_process
GO:0014065Phosphatidylinositol 3-kinase signalingISSbiological_process
GO:0030218Erythrocyte differentiationIEAbiological_process
GO:0031929TOR signalingISSbiological_process
GO:0032689Negative regulation of interferon-gamma productionIEAbiological_process
GO:0032703Negative regulation of interleukin-2 productionIEAbiological_process
GO:0032736Positive regulation of interleukin-13 productionIEAbiological_process
GO:0032753Positive regulation of interleukin-4 productionISSbiological_process
GO:0032754Positive regulation of interleukin-5 productionIEAbiological_process
GO:0033600Negative regulation of mammary gland epithelial cell proliferationIDAbiological_process
GO:0035162Embryonic hemopoiesisIEAbiological_process
GO:0035457Cellular response to interferon-alphaIEPbiological_process
GO:0035799Ureter maturationIEAbiological_process
GO:0035898Parathyroid hormone secretionIEAbiological_process
GO:0042035Regulation of cytokine biosynthetic processISSbiological_process
GO:0042421Norepinephrine biosynthetic processISSbiological_process
GO:0042472Inner ear morphogenesisIEAbiological_process
GO:0042493Response to drugIEAbiological_process
GO:0043370Regulation of CD4-positive, alpha-beta T cell differentiationIEAbiological_process
GO:0043523Regulation of neuron apoptotic processIEAbiological_process
GO:0043583Ear developmentIMPbiological_process
GO:0043627Response to estrogenIEPbiological_process
GO:0044212Transcription regulatory region DNA bindingIDAmolecular_function
GO:0045061Thymic T cell selectionIEAbiological_process
GO:0045064T-helper 2 cell differentiationIEAbiological_process
GO:0045471Response to ethanolIEAbiological_process
GO:0045582Positive regulation of T cell differentiationISSbiological_process
GO:0045599Negative regulation of fat cell differentiationIMPbiological_process
GO:0045786Negative regulation of cell cycleIMPbiological_process
GO:0045892Negative regulation of transcription, DNA-templatedIMPbiological_process
GO:0045893Positive regulation of transcription, DNA-templatedIDA IMP ISSbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIDA IMP ISSbiological_process
GO:0046983Protein dimerization activityIEAmolecular_function
GO:0048469Cell maturationIEAbiological_process
GO:0048485Sympathetic nervous system developmentISSbiological_process
GO:0048538Thymus developmentIEAbiological_process
GO:0048589Developmental growthIEAbiological_process
GO:0048646Anatomical structure formation involved in morphogenesisISSbiological_process
GO:0050728Negative regulation of inflammatory responseIMPbiological_process
GO:0050852T cell receptor signaling pathwayISSbiological_process
GO:0051569Regulation of histone H3-K4 methylationIEAbiological_process
GO:0051897Positive regulation of protein kinase B signalingIMPbiological_process
GO:0060017Parathyroid gland developmentIEAbiological_process
GO:0060037Pharyngeal system developmentISSbiological_process
GO:0060065Uterus developmentISSbiological_process
GO:0060231Mesenchymal to epithelial transitionIDAbiological_process
GO:0060374Mast cell differentiationIEAbiological_process
GO:0060676Ureteric bud formationISSbiological_process
GO:0061085Regulation of histone H3-K27 methylationIEAbiological_process
GO:0061290Canonical Wnt signaling pathway involved in metanephric kidney developmentISSbiological_process
GO:0070888E-box bindingIDAmolecular_function
GO:0071353Cellular response to interleukin-4IEPbiological_process
GO:0071356Cellular response to tumor necrosis factorIEPbiological_process
GO:0071599Otic vesicle developmentIEAbiological_process
GO:0071773Cellular response to BMP stimulusIEAbiological_process
GO:0071837HMG box domain bindingIPImolecular_function
GO:0072107Positive regulation of ureteric bud formationISSbiological_process
GO:0072178Nephric duct morphogenesisISSbiological_process
GO:0072179Nephric duct formationISSbiological_process
GO:0072182Regulation of nephron tubule epithelial cell differentiationISSbiological_process
GO:0072602Interleukin-4 secretionIEAbiological_process
GO:0072643Interferon-gamma secretionIEAbiological_process
GO:0072676Lymphocyte migrationIDAbiological_process
GO:2000114Regulation of establishment of cell polarityIEAbiological_process
GO:2000146Negative regulation of cell motilityIMPbiological_process
GO:2000352Negative regulation of endothelial cell apoptotic processIMPbiological_process
GO:2000607Negative regulation of cell proliferation involved in mesonephros developmentISSbiological_process
GO:2000611Positive regulation of thyroid hormone generationIMPbiological_process
GO:2000664Positive regulation of interleukin-5 secretionIDAbiological_process
GO:2000667Positive regulation of interleukin-13 secretionIDA IMPbiological_process
GO:2000679Positive regulation of transcription regulatory region DNA bindingIMPbiological_process
GO:2000683Regulation of cellular response to X-rayIMPbiological_process
GO:2000703Negative regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formationISSbiological_process
GO:2000734Negative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formationISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.79497519470.24887641050.99999024730.9588225995

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0172057640
GSE13712_SHEARDown-1.1031596677
GSE13712_STATICDown-1.3272379769
GSE19018Up0.0895606191
GSE19899_A1Up0.1210993863
GSE19899_A2Down-0.1108506281
PubMed_21979375_A1Down-0.0328726565
PubMed_21979375_A2Up0.0079085973
GSE35957Up0.0490578788
GSE36640Up0.8973060486
GSE54402Down-0.0730384690
GSE9593Down-0.0027252273
GSE43922Down-0.0373240611
GSE24585Up0.0615126165
GSE37065Down-0.0515267764
GSE28863_A1Down-0.1381833156
GSE28863_A2Down-0.0243770541
GSE28863_A3Up0.3429324902
GSE28863_A4Up0.0713896115
GSE48662Down-0.0946792399

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-132-3pMIMAT0000426MIRT021783MicroarrayFunctional MTI (Weak)17612493
hsa-miR-1MIMAT0000416MIRT024016MicroarrayFunctional MTI (Weak)18668037
hsa-miR-92a-3pMIMAT0000092MIRT049754CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.