HCSGD entry for TAB3

1. General information

Official gene symbolTAB3
Entrez ID257397
Gene full nameTGF-beta activated kinase 1/MAP3K7 binding protein 3
Other gene symbolsMAP3K7IP3 NAP1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000187Activation of MAPK activityTASbiological_process
GO:0002224Toll-like receptor signaling pathwayTASbiological_process
GO:0002755MyD88-dependent toll-like receptor signaling pathwayTASbiological_process
GO:0002756MyD88-independent toll-like receptor signaling pathwayTASbiological_process
GO:0005515Protein bindingIPImolecular_function
GO:0005829CytosolTAScellular_component
GO:0005886Plasma membraneTAScellular_component
GO:0007249I-kappaB kinase/NF-kappaB signalingTASbiological_process
GO:0007254JNK cascadeTASbiological_process
GO:0008270Zinc ion bindingIEAmolecular_function
GO:0010008Endosome membraneTAScellular_component
GO:0034134Toll-like receptor 2 signaling pathwayTASbiological_process
GO:0034138Toll-like receptor 3 signaling pathwayTASbiological_process
GO:0034142Toll-like receptor 4 signaling pathwayTASbiological_process
GO:0034146Toll-like receptor 5 signaling pathwayTASbiological_process
GO:0034162Toll-like receptor 9 signaling pathwayTASbiological_process
GO:0034166Toll-like receptor 10 signaling pathwayTASbiological_process
GO:0035666TRIF-dependent toll-like receptor signaling pathwayTASbiological_process
GO:0035872Nucleotide-binding domain, leucine rich repeat containing receptor signaling pathwayTASbiological_process
GO:0038095Fc-epsilon receptor signaling pathwayTASbiological_process
GO:0038123Toll-like receptor TLR1:TLR2 signaling pathwayTASbiological_process
GO:0038124Toll-like receptor TLR6:TLR2 signaling pathwayTASbiological_process
GO:0045087Innate immune responseTASbiological_process
GO:0051092Positive regulation of NF-kappaB transcription factor activityTASbiological_process
GO:0051403Stress-activated MAPK cascadeTASbiological_process
GO:0070423Nucleotide-binding oligomerization domain containing signaling pathwayTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.07006007750.77755845140.56610456361.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0454184299
GSE13712_SHEARUp0.1460168048
GSE13712_STATICUp0.0815079430
GSE19018Up0.0825257300
GSE19899_A1Up0.1971783761
GSE19899_A2Up0.5568951565
PubMed_21979375_A1Up0.8918249150
PubMed_21979375_A2Up0.4796533896
GSE35957Up0.5302797256
GSE36640Up0.2876805115
GSE54402Up0.3596660203
GSE9593Up0.1097877613
GSE43922Up0.4722091923
GSE24585Down-0.4954573648
GSE37065Up0.2139276490
GSE28863_A1Down-0.3803943608
GSE28863_A2Down-0.0866892381
GSE28863_A3Down-0.7282689102
GSE28863_A4Up0.0386242576
GSE48662Up0.0092636615

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-23b-3pMIMAT0000418MIRT007039Luciferase reporter assayFunctional MTI22660635
hsa-miR-195-5pMIMAT0000461MIRT007170Luciferase reporter assayFunctional MTI23487264
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.