HCSGD entry for TAB3

1. General information

Official gene symbolTAB3
Entrez ID257397
Gene full nameTGF-beta activated kinase 1/MAP3K7 binding protein 3
Other gene symbolsMAP3K7IP3 NAP1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000187Activation of MAPK activityTASbiological_process
GO:0002224Toll-like receptor signaling pathwayTASbiological_process
GO:0002755MyD88-dependent toll-like receptor signaling pathwayTASbiological_process
GO:0002756MyD88-independent toll-like receptor signaling pathwayTASbiological_process
GO:0005515Protein bindingIPImolecular_function
GO:0005829CytosolTAScellular_component
GO:0005886Plasma membraneTAScellular_component
GO:0007249I-kappaB kinase/NF-kappaB signalingTASbiological_process
GO:0007254JNK cascadeTASbiological_process
GO:0008270Zinc ion bindingIEAmolecular_function
GO:0010008Endosome membraneTAScellular_component
GO:0034134Toll-like receptor 2 signaling pathwayTASbiological_process
GO:0034138Toll-like receptor 3 signaling pathwayTASbiological_process
GO:0034142Toll-like receptor 4 signaling pathwayTASbiological_process
GO:0034146Toll-like receptor 5 signaling pathwayTASbiological_process
GO:0034162Toll-like receptor 9 signaling pathwayTASbiological_process
GO:0034166Toll-like receptor 10 signaling pathwayTASbiological_process
GO:0035666TRIF-dependent toll-like receptor signaling pathwayTASbiological_process
GO:0035872Nucleotide-binding domain, leucine rich repeat containing receptor signaling pathwayTASbiological_process
GO:0038095Fc-epsilon receptor signaling pathwayTASbiological_process
GO:0038123Toll-like receptor TLR1:TLR2 signaling pathwayTASbiological_process
GO:0038124Toll-like receptor TLR6:TLR2 signaling pathwayTASbiological_process
GO:0045087Innate immune responseTASbiological_process
GO:0051092Positive regulation of NF-kappaB transcription factor activityTASbiological_process
GO:0051403Stress-activated MAPK cascadeTASbiological_process
GO:0070423Nucleotide-binding oligomerization domain containing signaling pathwayTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.07006007750.77755845140.56610456361.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0454184299
GSE13712_SHEARUp0.1460168048
GSE13712_STATICUp0.0815079430
GSE19018Up0.0825257300
GSE19899_A1Up0.1971783761
GSE19899_A2Up0.5568951565
PubMed_21979375_A1Up0.8918249150
PubMed_21979375_A2Up0.4796533896
GSE35957Up0.5302797256
GSE36640Up0.2876805115
GSE54402Up0.3596660203
GSE9593Up0.1097877613
GSE43922Up0.4722091923
GSE24585Down-0.4954573648
GSE37065Up0.2139276490
GSE28863_A1Down-0.3803943608
GSE28863_A2Down-0.0866892381
GSE28863_A3Down-0.7282689102
GSE28863_A4Up0.0386242576
GSE48662Up0.0092636615

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-23b-3pMIMAT0000418MIRT007039Luciferase reporter assayFunctional MTI22660635
hsa-miR-195-5pMIMAT0000461MIRT007170Luciferase reporter assayFunctional MTI23487264
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.