HCSGD entry for GAD1

1. General information

Official gene symbolGAD1
Entrez ID2571
Gene full nameglutamate decarboxylase 1 (brain, 67kDa)
Other gene symbolsCPSQ1 GAD SCP
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0004351Glutamate decarboxylase activityIDA IEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005622IntracellularIDAcellular_component
GO:0005739MitochondrionIEAcellular_component
GO:0005886Plasma membraneTAScellular_component
GO:0005938Cell cortexIEAcellular_component
GO:0006538Glutamate catabolic processTASbiological_process
GO:0006540Glutamate decarboxylation to succinateTASbiological_process
GO:0007268Synaptic transmissionTASbiological_process
GO:0007269Neurotransmitter secretionTASbiological_process
GO:0009449Gamma-aminobutyric acid biosynthetic processIEAbiological_process
GO:0012506Vesicle membraneNAScellular_component
GO:0016595Glutamate bindingIEAmolecular_function
GO:0016831Carboxy-lyase activityIEAmolecular_function
GO:0018352Protein-pyridoxal-5-phosphate linkageTASbiological_process
GO:0019752Carboxylic acid metabolic processIEAbiological_process
GO:0030170Pyridoxal phosphate bindingIEAmolecular_function
GO:0042136Neurotransmitter biosynthetic processIEAbiological_process
GO:0042493Response to drugIEAbiological_process
GO:0043679Axon terminusIEAcellular_component
GO:0046982Protein heterodimerization activityIEAmolecular_function
GO:0047485Protein N-terminus bindingIEAmolecular_function
GO:0048786Presynaptic active zoneIEAcellular_component
GO:0061202Clathrin-sculpted gamma-aminobutyric acid transport vesicle membraneTAScellular_component
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.44059963150.55772318680.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.4167962591
GSE13712_SHEARDown-0.0774748393
GSE13712_STATICUp0.0266783988
GSE19018Up0.0896697229
GSE19899_A1Up0.1907917870
GSE19899_A2Up0.1510731877
PubMed_21979375_A1Up0.3867650624
PubMed_21979375_A2Up0.2815043425
GSE35957Up0.0307574191
GSE36640Up0.2418183507
GSE54402Up0.1017804203
GSE9593Up0.0462540274
GSE43922Up0.0133824986
GSE24585Down-0.3746550413
GSE37065Down-0.2990276167
GSE28863_A1Down-0.3806288986
GSE28863_A2Up0.4190911144
GSE28863_A3Down-0.4787427940
GSE28863_A4Down-0.0272845350
GSE48662Down-0.1153918108

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

L-Glutamic AcidDB00142 NUTR00027

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.