HCSGD entry for GABPA

1. General information

Official gene symbolGABPA
Entrez ID2551
Gene full nameGA binding protein transcription factor, alpha subunit 60kDa
Other gene symbolsE4TF1-60 E4TF1A NFT2 NRF2 NRF2A RCH04A07
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterIEAbiological_process
GO:0000790Nuclear chromatinIDAcellular_component
GO:0000978RNA polymerase II core promoter proximal region sequence-specific DNA bindingIDAmolecular_function
GO:0001228RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptionIDAmolecular_function
GO:0001701In utero embryonic developmentIEAbiological_process
GO:0003677DNA bindingTASmolecular_function
GO:0003682Chromatin bindingIEAmolecular_function
GO:0003700Sequence-specific DNA binding transcription factor activityTASmolecular_function
GO:0003713Transcription coactivator activityTASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005730NucleolusIDAcellular_component
GO:0006366Transcription from RNA polymerase II promoterTASbiological_process
GO:0044212Transcription regulatory region DNA bindingIDAmolecular_function
GO:0045653Negative regulation of megakaryocyte differentiationIEAbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIDAbiological_process
GO:0046982Protein heterodimerization activityIDAmolecular_function
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.05651654190.67828758790.51620891741.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0857147168
GSE13712_SHEARUp0.2476349060
GSE13712_STATICDown-0.1577753891
GSE19018Down-0.1080192577
GSE19899_A1Up0.6967844986
GSE19899_A2Up0.4903398056
PubMed_21979375_A1Up1.4353613436
PubMed_21979375_A2Up1.3598952361
GSE35957Up0.1544953024
GSE36640Down-0.2169057970
GSE54402Up0.3777139914
GSE9593Down-0.2989482369
GSE43922Up0.4647314656
GSE24585Down-0.1018138911
GSE37065Up0.0084095487
GSE28863_A1Down-0.1461121253
GSE28863_A2Down-0.0647153450
GSE28863_A3Down-0.0352310879
GSE28863_A4Up0.0660991279
GSE48662Down-0.4572749122

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-18a-5pMIMAT0000072MIRT031329SequencingFunctional MTI (Weak)20371350
hsa-miR-92a-3pMIMAT0000092MIRT048948CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.