HCSGD entry for ALOX12

1. General information

Official gene symbolALOX12
Entrez ID239
Gene full namearachidonate 12-lipoxygenase
Other gene symbols12-LOX 12S-LOX LOG12
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0004052Arachidonate 12-lipoxygenase activityIDA TASmolecular_function
GO:0005506Iron ion bindingIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005737CytoplasmIDAcellular_component
GO:0005829CytosolIDA TAScellular_component
GO:0006928Cellular component movementIMPbiological_process
GO:0007568AgingIEAbiological_process
GO:0008284Positive regulation of cell proliferationIMP ISSbiological_process
GO:0010595Positive regulation of endothelial cell migrationIEAbiological_process
GO:0010628Positive regulation of gene expressionIEAbiological_process
GO:0010656Negative regulation of muscle cell apoptotic processIMPbiological_process
GO:0016020MembraneIDAcellular_component
GO:0016165Linoleate 13S-lipoxygenase activityIDAmolecular_function
GO:0016702Oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygenIEA TASmolecular_function
GO:0019369Arachidonic acid metabolic processIDA ISS TASbiological_process
GO:0019372Lipoxygenase pathwayIDA TASbiological_process
GO:0019395Fatty acid oxidationIMPbiological_process
GO:0030307Positive regulation of cell growthIMPbiological_process
GO:0030335Positive regulation of cell migrationIMPbiological_process
GO:0042383SarcolemmaIDAcellular_component
GO:0042554Superoxide anion generationNASbiological_process
GO:0043065Positive regulation of apoptotic processIEAbiological_process
GO:0043066Negative regulation of apoptotic processIMP ISSbiological_process
GO:0043280Positive regulation of cysteine-type endopeptidase activity involved in apoptotic processIEAbiological_process
GO:0043651Linoleic acid metabolic processIDAbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0045603Positive regulation of endothelial cell differentiationIEAbiological_process
GO:0045766Positive regulation of angiogenesisIMPbiological_process
GO:0045785Positive regulation of cell adhesionIMPbiological_process
GO:0045909Positive regulation of vasodilationIEAbiological_process
GO:0047977Hepoxilin-epoxide hydrolase activityISSmolecular_function
GO:0048661Positive regulation of smooth muscle cell proliferationIEAbiological_process
GO:0051120Hepoxilin A3 synthase activityTASmolecular_function
GO:0051121Hepoxilin metabolic processTASbiological_process
GO:0051122Hepoxilin biosynthetic processISSbiological_process
GO:0051901Positive regulation of mitochondrial depolarizationIEAbiological_process
GO:0061436Establishment of skin barrierISSbiological_process
GO:0071396Cellular response to lipidIEAbiological_process
GO:0072593Reactive oxygen species metabolic processNASbiological_process
GO:0090331Negative regulation of platelet aggregationISSbiological_process
GO:1901751Leukotriene A4 metabolic processIDAbiological_process
GO:2001300Lipoxin metabolic processTASbiological_process
GO:2001303Lipoxin A4 biosynthetic processIDAbiological_process
GO:2001306Lipoxin B4 biosynthetic processIDAbiological_process
Entries Per Page
Displaying Page of

4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.72498346950.50709777740.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0119884387
GSE13712_SHEARUp0.2341492836
GSE13712_STATICDown-0.1003205106
GSE19018Up0.1321504380
GSE19899_A1Up0.1107904834
GSE19899_A2Up0.4292884135
PubMed_21979375_A1Down-0.0393455017
PubMed_21979375_A2Up0.2789093167
GSE35957Down-0.0268611895
GSE36640Down-0.1115249086
GSE54402Down-0.3600816824
GSE9593Down-0.0722516647
GSE43922Up0.0135178043
GSE24585Up0.0849836199
GSE37065Down-0.0256610031
GSE28863_A1Down-0.2234294323
GSE28863_A2Down-0.3143888687
GSE28863_A3Up0.1179715150
GSE28863_A4Up0.0158896018
GSE48662Down-0.1317576903

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.