HCSGD entry for ALOX12

1. General information

Official gene symbolALOX12
Entrez ID239
Gene full namearachidonate 12-lipoxygenase
Other gene symbols12-LOX 12S-LOX LOG12
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0004052Arachidonate 12-lipoxygenase activityIDA TASmolecular_function
GO:0005506Iron ion bindingIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005737CytoplasmIDAcellular_component
GO:0005829CytosolIDA TAScellular_component
GO:0006928Cellular component movementIMPbiological_process
GO:0007568AgingIEAbiological_process
GO:0008284Positive regulation of cell proliferationIMP ISSbiological_process
GO:0010595Positive regulation of endothelial cell migrationIEAbiological_process
GO:0010628Positive regulation of gene expressionIEAbiological_process
GO:0010656Negative regulation of muscle cell apoptotic processIMPbiological_process
GO:0016020MembraneIDAcellular_component
GO:0016165Linoleate 13S-lipoxygenase activityIDAmolecular_function
GO:0016702Oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygenIEA TASmolecular_function
GO:0019369Arachidonic acid metabolic processIDA ISS TASbiological_process
GO:0019372Lipoxygenase pathwayIDA TASbiological_process
GO:0019395Fatty acid oxidationIMPbiological_process
GO:0030307Positive regulation of cell growthIMPbiological_process
GO:0030335Positive regulation of cell migrationIMPbiological_process
GO:0042383SarcolemmaIDAcellular_component
GO:0042554Superoxide anion generationNASbiological_process
GO:0043065Positive regulation of apoptotic processIEAbiological_process
GO:0043066Negative regulation of apoptotic processIMP ISSbiological_process
GO:0043280Positive regulation of cysteine-type endopeptidase activity involved in apoptotic processIEAbiological_process
GO:0043651Linoleic acid metabolic processIDAbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0045603Positive regulation of endothelial cell differentiationIEAbiological_process
GO:0045766Positive regulation of angiogenesisIMPbiological_process
GO:0045785Positive regulation of cell adhesionIMPbiological_process
GO:0045909Positive regulation of vasodilationIEAbiological_process
GO:0047977Hepoxilin-epoxide hydrolase activityISSmolecular_function
GO:0048661Positive regulation of smooth muscle cell proliferationIEAbiological_process
GO:0051120Hepoxilin A3 synthase activityTASmolecular_function
GO:0051121Hepoxilin metabolic processTASbiological_process
GO:0051122Hepoxilin biosynthetic processISSbiological_process
GO:0051901Positive regulation of mitochondrial depolarizationIEAbiological_process
GO:0061436Establishment of skin barrierISSbiological_process
GO:0071396Cellular response to lipidIEAbiological_process
GO:0072593Reactive oxygen species metabolic processNASbiological_process
GO:0090331Negative regulation of platelet aggregationISSbiological_process
GO:1901751Leukotriene A4 metabolic processIDAbiological_process
GO:2001300Lipoxin metabolic processTASbiological_process
GO:2001303Lipoxin A4 biosynthetic processIDAbiological_process
GO:2001306Lipoxin B4 biosynthetic processIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.72498346950.50709777740.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0119884387
GSE13712_SHEARUp0.2341492836
GSE13712_STATICDown-0.1003205106
GSE19018Up0.1321504380
GSE19899_A1Up0.1107904834
GSE19899_A2Up0.4292884135
PubMed_21979375_A1Down-0.0393455017
PubMed_21979375_A2Up0.2789093167
GSE35957Down-0.0268611895
GSE36640Down-0.1115249086
GSE54402Down-0.3600816824
GSE9593Down-0.0722516647
GSE43922Up0.0135178043
GSE24585Up0.0849836199
GSE37065Down-0.0256610031
GSE28863_A1Down-0.2234294323
GSE28863_A2Down-0.3143888687
GSE28863_A3Up0.1179715150
GSE28863_A4Up0.0158896018
GSE48662Down-0.1317576903

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.