HCSGD entry for MACF1
1. General information
| Official gene symbol | MACF1 |
|---|---|
| Entrez ID | 23499 |
| Gene full name | microtubule-actin crosslinking factor 1 |
| Other gene symbols | ABP620 ACF7 MACF OFC4 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001707 | Mesoderm formation | IEA | biological_process |
| GO:0003779 | Actin binding | IDA IEA | molecular_function |
| GO:0005509 | Calcium ion binding | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005737 | Cytoplasm | IDA ISS | cellular_component |
| GO:0005794 | Golgi apparatus | IDA | cellular_component |
| GO:0005856 | Cytoskeleton | IEA NAS | cellular_component |
| GO:0005874 | Microtubule | IDA | cellular_component |
| GO:0005886 | Plasma membrane | IDA | cellular_component |
| GO:0006200 | ATP catabolic process | ISS | biological_process |
| GO:0006620 | Posttranslational protein targeting to membrane | IEA | biological_process |
| GO:0006928 | Cellular component movement | IEA | biological_process |
| GO:0007050 | Cell cycle arrest | IEA | biological_process |
| GO:0007163 | Establishment or maintenance of cell polarity | IEA | biological_process |
| GO:0008017 | Microtubule binding | IEA | molecular_function |
| GO:0008152 | Metabolic process | ISS | biological_process |
| GO:0010632 | Regulation of epithelial cell migration | ISS | biological_process |
| GO:0015629 | Actin cytoskeleton | IEA | cellular_component |
| GO:0016055 | Wnt signaling pathway | IEA | biological_process |
| GO:0016887 | ATPase activity | IEA ISS | molecular_function |
| GO:0030177 | Positive regulation of Wnt signaling pathway | ISS | biological_process |
| GO:0032587 | Ruffle membrane | IDA | cellular_component |
| GO:0032886 | Regulation of microtubule-based process | IMP | biological_process |
| GO:0042060 | Wound healing | ISS | biological_process |
| GO:0043001 | Golgi to plasma membrane protein transport | IDA | biological_process |
| GO:0051015 | Actin filament binding | NAS | molecular_function |
| GO:0051893 | Regulation of focal adhesion assembly | ISS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0173608336 | 0.8585502678 | 0.3243112136 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.2410497969 |
| GSE13712_SHEAR | Up | 0.4391265029 |
| GSE13712_STATIC | Up | 0.1770891185 |
| GSE19018 | Up | 0.1290001915 |
| GSE19899_A1 | Down | -0.2423302442 |
| GSE19899_A2 | Down | -0.0537251736 |
| PubMed_21979375_A1 | Down | -0.6759280570 |
| PubMed_21979375_A2 | Up | 0.0619118259 |
| GSE35957 | Up | 0.3726081385 |
| GSE36640 | Up | 0.3333890355 |
| GSE54402 | Up | 0.2507372985 |
| GSE9593 | Up | 0.5541672777 |
| GSE43922 | Down | -0.0784698201 |
| GSE24585 | Up | 0.1363974755 |
| GSE37065 | Up | 0.0289206187 |
| GSE28863_A1 | Up | 1.3812483405 |
| GSE28863_A2 | Up | 1.7599094990 |
| GSE28863_A3 | Up | 0.1218893338 |
| GSE28863_A4 | Down | -0.1411635610 |
| GSE48662 | Up | 0.7041093907 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT018609 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-215-5p | MIMAT0000272 | MIRT024354 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-192-5p | MIMAT0000222 | MIRT026727 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT031887 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-296-3p | MIMAT0004679 | MIRT038342 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT040282 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-125a-5p | MIMAT0000443 | MIRT045723 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-222-3p | MIMAT0000279 | MIRT046675 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-30d-5p | MIMAT0000245 | MIRT047816 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049242 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7e-5p | MIMAT0000066 | MIRT051446 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
