HCSGD entry for MACF1

1. General information

Official gene symbolMACF1
Entrez ID23499
Gene full namemicrotubule-actin crosslinking factor 1
Other gene symbolsABP620 ACF7 MACF OFC4
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001707Mesoderm formationIEAbiological_process
GO:0003779Actin bindingIDA IEAmolecular_function
GO:0005509Calcium ion bindingIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005737CytoplasmIDA ISScellular_component
GO:0005794Golgi apparatusIDAcellular_component
GO:0005856CytoskeletonIEA NAScellular_component
GO:0005874MicrotubuleIDAcellular_component
GO:0005886Plasma membraneIDAcellular_component
GO:0006200ATP catabolic processISSbiological_process
GO:0006620Posttranslational protein targeting to membraneIEAbiological_process
GO:0006928Cellular component movementIEAbiological_process
GO:0007050Cell cycle arrestIEAbiological_process
GO:0007163Establishment or maintenance of cell polarityIEAbiological_process
GO:0008017Microtubule bindingIEAmolecular_function
GO:0008152Metabolic processISSbiological_process
GO:0010632Regulation of epithelial cell migrationISSbiological_process
GO:0015629Actin cytoskeletonIEAcellular_component
GO:0016055Wnt signaling pathwayIEAbiological_process
GO:0016887ATPase activityIEA ISSmolecular_function
GO:0030177Positive regulation of Wnt signaling pathwayISSbiological_process
GO:0032587Ruffle membraneIDAcellular_component
GO:0032886Regulation of microtubule-based processIMPbiological_process
GO:0042060Wound healingISSbiological_process
GO:0043001Golgi to plasma membrane protein transportIDAbiological_process
GO:0051015Actin filament bindingNASmolecular_function
GO:0051893Regulation of focal adhesion assemblyISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.01736083360.85855026780.32431121361.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.2410497969
GSE13712_SHEARUp0.4391265029
GSE13712_STATICUp0.1770891185
GSE19018Up0.1290001915
GSE19899_A1Down-0.2423302442
GSE19899_A2Down-0.0537251736
PubMed_21979375_A1Down-0.6759280570
PubMed_21979375_A2Up0.0619118259
GSE35957Up0.3726081385
GSE36640Up0.3333890355
GSE54402Up0.2507372985
GSE9593Up0.5541672777
GSE43922Down-0.0784698201
GSE24585Up0.1363974755
GSE37065Up0.0289206187
GSE28863_A1Up1.3812483405
GSE28863_A2Up1.7599094990
GSE28863_A3Up0.1218893338
GSE28863_A4Down-0.1411635610
GSE48662Up0.7041093907

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT018609MicroarrayFunctional MTI (Weak)18185580
hsa-miR-215-5pMIMAT0000272MIRT024354MicroarrayFunctional MTI (Weak)19074876
hsa-miR-192-5pMIMAT0000222MIRT026727MicroarrayFunctional MTI (Weak)19074876
hsa-miR-16-5pMIMAT0000069MIRT031887ProteomicsFunctional MTI (Weak)18668040
hsa-miR-296-3pMIMAT0004679MIRT038342CLASHFunctional MTI (Weak)23622248
hsa-miR-615-3pMIMAT0003283MIRT040282CLASHFunctional MTI (Weak)23622248
hsa-miR-125a-5pMIMAT0000443MIRT045723CLASHFunctional MTI (Weak)23622248
hsa-miR-222-3pMIMAT0000279MIRT046675CLASHFunctional MTI (Weak)23622248
hsa-miR-30d-5pMIMAT0000245MIRT047816CLASHFunctional MTI (Weak)23622248
hsa-miR-92a-3pMIMAT0000092MIRT049242CLASHFunctional MTI (Weak)23622248
hsa-let-7e-5pMIMAT0000066MIRT051446CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.