HCSGD entry for ACSL6

1. General information

Official gene symbolACSL6
Entrez ID23305
Gene full nameacyl-CoA synthetase long-chain family member 6
Other gene symbolsACS2 FACL6 LACS 6 LACS2 LACS5
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001666Response to hypoxiaIEAbiological_process
GO:0001676Long-chain fatty acid metabolic processIDAbiological_process
GO:0003824Catalytic activityIEAmolecular_function
GO:0004467Long-chain fatty acid-CoA ligase activityIDA IEA NASmolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005634NucleusIEAcellular_component
GO:0005739MitochondrionIEAcellular_component
GO:0005741Mitochondrial outer membraneIEAcellular_component
GO:0005778Peroxisomal membraneIEAcellular_component
GO:0005789Endoplasmic reticulum membraneTAScellular_component
GO:0005886Plasma membraneNAScellular_component
GO:0006637Acyl-CoA metabolic processNASbiological_process
GO:0006641Triglyceride metabolic processIEAbiological_process
GO:0007405Neuroblast proliferationIEAbiological_process
GO:0007584Response to nutrientIEAbiological_process
GO:0008654Phospholipid biosynthetic processIEAbiological_process
GO:0009629Response to gravityIEAbiological_process
GO:0010747Positive regulation of plasma membrane long-chain fatty acid transportIEAbiological_process
GO:0010867Positive regulation of triglyceride biosynthetic processIEAbiological_process
GO:0010976Positive regulation of neuron projection developmentIEAbiological_process
GO:0015908Fatty acid transportIEAbiological_process
GO:0016020MembraneIDAcellular_component
GO:0016021Integral component of membraneIEAcellular_component
GO:0019432Triglyceride biosynthetic processTASbiological_process
GO:0019899Enzyme bindingIPImolecular_function
GO:0032869Cellular response to insulin stimulusIEAbiological_process
GO:0035338Long-chain fatty-acyl-CoA biosynthetic processTASbiological_process
GO:0042803Protein homodimerization activityIDA IEAmolecular_function
GO:0044255Cellular lipid metabolic processTASbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0048545Response to steroid hormoneIEAbiological_process
GO:0048666Neuron developmentIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.53342789790.96538812740.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.1745739786
GSE13712_SHEARDown-0.0316638396
GSE13712_STATICUp0.0028704503
GSE19018Up0.0812498242
GSE19899_A1Up0.0546596821
GSE19899_A2Up0.0269985776
PubMed_21979375_A1Up0.3217579641
PubMed_21979375_A2Up0.0901327605
GSE35957Up0.0755435115
GSE36640Down-0.0086038842
GSE54402Up0.0619916162
GSE9593Up0.1007479734
GSE43922--
GSE24585--
GSE37065--
GSE28863_A1Up0.0171909629
GSE28863_A2Up0.0460561224
GSE28863_A3Up0.1598565787
GSE28863_A4Up0.0499559343
GSE48662Down-0.0073813435

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-34a-5pMIMAT0000255MIRT025504ProteomicsFunctional MTI (Weak)21566225
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.