HCSGD entry for KANK1

1. General information

Official gene symbolKANK1
Entrez ID23189
Gene full nameKN motif and ankyrin repeat domains 1
Other gene symbolsANKRD15 CPSQ2 KANK
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDA IEAcellular_component
GO:0005737CytoplasmIDA IEAcellular_component
GO:0006351Transcription, DNA-templatedIEAbiological_process
GO:0006355Regulation of transcription, DNA-templatedIEAbiological_process
GO:0008013Beta-catenin bindingIDAmolecular_function
GO:0010977Negative regulation of neuron projection developmentIDAbiological_process
GO:0030177Positive regulation of Wnt signaling pathwayIDAbiological_process
GO:0030336Negative regulation of cell migrationIMPbiological_process
GO:0030837Negative regulation of actin filament polymerizationIDAbiological_process
GO:0032587Ruffle membraneIDAcellular_component
GO:0035024Negative regulation of Rho protein signal transductionIMPbiological_process
GO:0035413Positive regulation of catenin import into nucleusIMPbiological_process
GO:0046627Negative regulation of insulin receptor signaling pathwayIMPbiological_process
GO:0090303Positive regulation of wound healingIMPbiological_process
GO:1900025Negative regulation of substrate adhesion-dependent cell spreadingIDAbiological_process
GO:1900028Negative regulation of ruffle assemblyIDAbiological_process
GO:2000114Regulation of establishment of cell polarityIMPbiological_process
GO:2000393Negative regulation of lamellipodium morphogenesisIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.85167626610.17256792300.99999024730.8042068520

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0872502265
GSE13712_SHEARUp0.1749389249
GSE13712_STATICDown-0.1018376100
GSE19018Down-0.1095372564
GSE19899_A1Down-0.5669313156
GSE19899_A2Down-0.1544783558
PubMed_21979375_A1Down-0.2592453905
PubMed_21979375_A2Down-0.1868025774
GSE35957Up0.4433437909
GSE36640Up0.2260677157
GSE54402Down-0.1992018610
GSE9593Up0.1214438452
GSE43922Down-0.6047946328
GSE24585Up0.1071274232
GSE37065Up0.2891986773
GSE28863_A1Up0.1018852118
GSE28863_A2Down-0.2620334838
GSE28863_A3Down-0.1394021959
GSE28863_A4Up0.1116963502
GSE48662Down-0.1661626630

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-124-3pMIMAT0000422MIRT004930MicroarrayFunctional MTI (Weak)15685193
hsa-miR-124-3pMIMAT0000422MIRT004930MicroarrayFunctional MTI (Weak)18668037
hsa-miR-335-5pMIMAT0000765MIRT017826MicroarrayFunctional MTI (Weak)18185580
hsa-miR-10a-5pMIMAT0000253MIRT047719CLASHFunctional MTI (Weak)23622248
hsa-miR-100-5pMIMAT0000098MIRT048597CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.