HCSGD entry for KANK1

1. General information

Official gene symbolKANK1
Entrez ID23189
Gene full nameKN motif and ankyrin repeat domains 1
Other gene symbolsANKRD15 CPSQ2 KANK
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDA IEAcellular_component
GO:0005737CytoplasmIDA IEAcellular_component
GO:0006351Transcription, DNA-templatedIEAbiological_process
GO:0006355Regulation of transcription, DNA-templatedIEAbiological_process
GO:0008013Beta-catenin bindingIDAmolecular_function
GO:0010977Negative regulation of neuron projection developmentIDAbiological_process
GO:0030177Positive regulation of Wnt signaling pathwayIDAbiological_process
GO:0030336Negative regulation of cell migrationIMPbiological_process
GO:0030837Negative regulation of actin filament polymerizationIDAbiological_process
GO:0032587Ruffle membraneIDAcellular_component
GO:0035024Negative regulation of Rho protein signal transductionIMPbiological_process
GO:0035413Positive regulation of catenin import into nucleusIMPbiological_process
GO:0046627Negative regulation of insulin receptor signaling pathwayIMPbiological_process
GO:0090303Positive regulation of wound healingIMPbiological_process
GO:1900025Negative regulation of substrate adhesion-dependent cell spreadingIDAbiological_process
GO:1900028Negative regulation of ruffle assemblyIDAbiological_process
GO:2000114Regulation of establishment of cell polarityIMPbiological_process
GO:2000393Negative regulation of lamellipodium morphogenesisIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.85167626610.17256792300.99999024730.8042068520

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0872502265
GSE13712_SHEARUp0.1749389249
GSE13712_STATICDown-0.1018376100
GSE19018Down-0.1095372564
GSE19899_A1Down-0.5669313156
GSE19899_A2Down-0.1544783558
PubMed_21979375_A1Down-0.2592453905
PubMed_21979375_A2Down-0.1868025774
GSE35957Up0.4433437909
GSE36640Up0.2260677157
GSE54402Down-0.1992018610
GSE9593Up0.1214438452
GSE43922Down-0.6047946328
GSE24585Up0.1071274232
GSE37065Up0.2891986773
GSE28863_A1Up0.1018852118
GSE28863_A2Down-0.2620334838
GSE28863_A3Down-0.1394021959
GSE28863_A4Up0.1116963502
GSE48662Down-0.1661626630

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-124-3pMIMAT0000422MIRT004930MicroarrayFunctional MTI (Weak)15685193
hsa-miR-124-3pMIMAT0000422MIRT004930MicroarrayFunctional MTI (Weak)18668037
hsa-miR-335-5pMIMAT0000765MIRT017826MicroarrayFunctional MTI (Weak)18185580
hsa-miR-10a-5pMIMAT0000253MIRT047719CLASHFunctional MTI (Weak)23622248
hsa-miR-100-5pMIMAT0000098MIRT048597CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.