HCSGD entry for ARHGAP26
1. General information
| Official gene symbol | ARHGAP26 |
|---|---|
| Entrez ID | 23092 |
| Gene full name | Rho GTPase activating protein 26 |
| Other gene symbols | GRAF GRAF1 OPHN1L OPHN1L1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005100 | Rho GTPase activator activity | NAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005543 | Phospholipid binding | IDA | molecular_function |
| GO:0005575 | Cellular_component | ND | cellular_component |
| GO:0005622 | Intracellular | IEA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0005856 | Cytoskeleton | IEA | cellular_component |
| GO:0005925 | Focal adhesion | IEA | cellular_component |
| GO:0007165 | Signal transduction | IEA | biological_process |
| GO:0007264 | Small GTPase mediated signal transduction | TAS | biological_process |
| GO:0007399 | Nervous system development | NAS | biological_process |
| GO:0008093 | Cytoskeletal adaptor activity | IEA | molecular_function |
| GO:0017124 | SH3 domain binding | IEA | molecular_function |
| GO:0030036 | Actin cytoskeleton organization | NAS | biological_process |
| GO:0032320 | Positive regulation of Ras GTPase activity | NAS | biological_process |
| GO:0032321 | Positive regulation of Rho GTPase activity | NAS | biological_process |
| GO:0043085 | Positive regulation of catalytic activity | NAS | biological_process |
| GO:0043547 | Positive regulation of GTPase activity | NAS | biological_process |
| GO:0046847 | Filopodium assembly | IEA | biological_process |
| GO:0050790 | Regulation of catalytic activity | NAS | biological_process |
| GO:0051056 | Regulation of small GTPase mediated signal transduction | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0006614946 | 0.9983445804 | 0.0740632911 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1429138022 |
| GSE13712_SHEAR | Up | 1.0799850009 |
| GSE13712_STATIC | Up | 0.9708159975 |
| GSE19018 | Up | 0.2186506605 |
| GSE19899_A1 | Up | 0.4355214805 |
| GSE19899_A2 | Up | 1.0449535022 |
| PubMed_21979375_A1 | Up | 1.3794117205 |
| PubMed_21979375_A2 | Up | 1.6366784699 |
| GSE35957 | Down | -0.0575574999 |
| GSE36640 | Up | 0.5240240230 |
| GSE54402 | Up | 0.2713354374 |
| GSE9593 | Up | 0.5530110706 |
| GSE43922 | Up | 1.3646428771 |
| GSE24585 | Up | 0.2153852612 |
| GSE37065 | Down | -0.0227792193 |
| GSE28863_A1 | Up | 0.4426734232 |
| GSE28863_A2 | Up | 0.5402836279 |
| GSE28863_A3 | Up | 0.3297398834 |
| GSE28863_A4 | Up | 0.0860714914 |
| GSE48662 | Up | 0.3326547374 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-324-3p | MIMAT0000762 | MIRT042845 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-320a | MIMAT0000510 | MIRT044784 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7b-5p | MIMAT0000063 | MIRT052044 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
