HCSGD entry for PHLPP2
1. General information
| Official gene symbol | PHLPP2 |
|---|---|
| Entrez ID | 23035 |
| Gene full name | PH domain and leucine rich repeat protein phosphatase 2 |
| Other gene symbols | PHLPPL |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001917 | Photoreceptor inner segment | IEA | cellular_component |
| GO:0003824 | Catalytic activity | IEA | molecular_function |
| GO:0004722 | Protein serine/threonine phosphatase activity | IEA | molecular_function |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006470 | Protein dephosphorylation | IEA | biological_process |
| GO:0007173 | Epidermal growth factor receptor signaling pathway | TAS | biological_process |
| GO:0008543 | Fibroblast growth factor receptor signaling pathway | TAS | biological_process |
| GO:0038095 | Fc-epsilon receptor signaling pathway | TAS | biological_process |
| GO:0042622 | Photoreceptor outer segment membrane | IEA | cellular_component |
| GO:0045087 | Innate immune response | TAS | biological_process |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
| GO:0048011 | Neurotrophin TRK receptor signaling pathway | TAS | biological_process |
| GO:0048015 | Phosphatidylinositol-mediated signaling | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.7363342160 | 0.1731368717 | 0.9999902473 | 0.8055531460 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1322380383 |
| GSE13712_SHEAR | Up | 0.1058220856 |
| GSE13712_STATIC | Up | 0.1303166942 |
| GSE19018 | Down | -0.8614185068 |
| GSE19899_A1 | Down | -0.0617875947 |
| GSE19899_A2 | Down | -0.2143413332 |
| PubMed_21979375_A1 | Up | 0.6124037376 |
| PubMed_21979375_A2 | Down | -0.0688324560 |
| GSE35957 | Down | -0.1826592753 |
| GSE36640 | Down | -0.4505930642 |
| GSE54402 | Up | 0.5107577970 |
| GSE9593 | Down | -0.1376401505 |
| GSE43922 | Up | 0.2237036446 |
| GSE24585 | Up | 0.0421841978 |
| GSE37065 | Up | 0.1105879496 |
| GSE28863_A1 | Down | -0.0928064751 |
| GSE28863_A2 | Down | -0.0952568225 |
| GSE28863_A3 | Down | -0.4566921926 |
| GSE28863_A4 | Up | 0.0689424437 |
| GSE48662 | Down | -0.2370090072 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-93-5p | MIMAT0000093 | MIRT028173 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-32-5p | MIMAT0000090 | MIRT028376 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-26b-5p | MIMAT0000083 | MIRT030284 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-769-5p | MIMAT0003886 | MIRT039169 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-421 | MIMAT0003339 | MIRT039453 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 23174937 | Potentially functional polymorphisms were found in vascular endothelial growth factor (VEGF), ABCB1, FGFR2 and PHLPP2 |
| 23174937 | PHLPP2 polymorphisms were more frequent in mucinous as compared with serous tumors (P=0 |
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