HCSGD entry for PHLPP2


1. General information

Official gene symbolPHLPP2
Entrez ID23035
Gene full namePH domain and leucine rich repeat protein phosphatase 2
Other gene symbolsPHLPPL
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001917Photoreceptor inner segmentIEAcellular_component
GO:0003824Catalytic activityIEAmolecular_function
GO:0004722Protein serine/threonine phosphatase activityIEAmolecular_function
GO:0005634NucleusIEAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005829CytosolTAScellular_component
GO:0006470Protein dephosphorylationIEAbiological_process
GO:0007173Epidermal growth factor receptor signaling pathwayTASbiological_process
GO:0008543Fibroblast growth factor receptor signaling pathwayTASbiological_process
GO:0038095Fc-epsilon receptor signaling pathwayTASbiological_process
GO:0042622Photoreceptor outer segment membraneIEAcellular_component
GO:0045087Innate immune responseTASbiological_process
GO:0046872Metal ion bindingIEAmolecular_function
GO:0048011Neurotrophin TRK receptor signaling pathwayTASbiological_process
GO:0048015Phosphatidylinositol-mediated signalingTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.73633421600.17313687170.99999024730.8055531460

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.1322380383
GSE13712_SHEARUp0.1058220856
GSE13712_STATICUp0.1303166942
GSE19018Down-0.8614185068
GSE19899_A1Down-0.0617875947
GSE19899_A2Down-0.2143413332
PubMed_21979375_A1Up0.6124037376
PubMed_21979375_A2Down-0.0688324560
GSE35957Down-0.1826592753
GSE36640Down-0.4505930642
GSE54402Up0.5107577970
GSE9593Down-0.1376401505
GSE43922Up0.2237036446
GSE24585Up0.0421841978
GSE37065Up0.1105879496
GSE28863_A1Down-0.0928064751
GSE28863_A2Down-0.0952568225
GSE28863_A3Down-0.4566921926
GSE28863_A4Up0.0689424437
GSE48662Down-0.2370090072

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-93-5pMIMAT0000093MIRT028173SequencingFunctional MTI (Weak)20371350
hsa-miR-32-5pMIMAT0000090MIRT028376SequencingFunctional MTI (Weak)20371350
hsa-miR-26b-5pMIMAT0000083MIRT030284MicroarrayFunctional MTI (Weak)19088304
hsa-miR-769-5pMIMAT0003886MIRT039169CLASHFunctional MTI (Weak)23622248
hsa-miR-421MIMAT0003339MIRT039453CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

23174937Potentially functional polymorphisms were found in vascular endothelial growth factor (VEGF), ABCB1, FGFR2 and PHLPP2
23174937PHLPP2 polymorphisms were more frequent in mucinous as compared with serous tumors (P=0
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