HCSGD entry for FOXC2

1. General information

Official gene symbolFOXC2
Entrez ID2303
Gene full nameforkhead box C2 (MFH-1, mesenchyme forkhead 1)
Other gene symbolsFKHL14 LD MFH-1 MFH1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterIBA ISSbiological_process
GO:0001077RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcriptionIDAmolecular_function
GO:0001503OssificationIBAbiological_process
GO:0001569Patterning of blood vesselsIBAbiological_process
GO:0001656Metanephros developmentIBAbiological_process
GO:0001657Ureteric bud developmentIBAbiological_process
GO:0001756SomitogenesisIBAbiological_process
GO:0001946LymphangiogenesisIMPbiological_process
GO:0001974Blood vessel remodelingIBAbiological_process
GO:0003690Double-stranded DNA bindingIBAmolecular_function
GO:0003700Sequence-specific DNA binding transcription factor activityIDAmolecular_function
GO:0003705RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activityIBAmolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005667Transcription factor complexIBAcellular_component
GO:0006366Transcription from RNA polymerase II promoterIBA IDAbiological_process
GO:0007219Notch signaling pathwayIBAbiological_process
GO:0007498Mesoderm developmentNASbiological_process
GO:0007507Heart developmentIMPbiological_process
GO:0008134Transcription factor bindingIBAmolecular_function
GO:0008286Insulin receptor signaling pathwayIDAbiological_process
GO:0008301DNA binding, bendingIBAmolecular_function
GO:0009725Response to hormoneIDAbiological_process
GO:0010595Positive regulation of endothelial cell migrationISSbiological_process
GO:0014032Neural crest cell developmentIEAbiological_process
GO:0030199Collagen fibril organizationIBAbiological_process
GO:0031490Chromatin DNA bindingIDAmolecular_function
GO:0033630Positive regulation of cell adhesion mediated by integrinISSbiological_process
GO:0035050Embryonic heart tube developmentIBAbiological_process
GO:0035470Positive regulation of vascular wound healingISSbiological_process
GO:0043010Camera-type eye developmentIBAbiological_process
GO:0043066Negative regulation of apoptotic processIBAbiological_process
GO:0043565Sequence-specific DNA bindingIDAmolecular_function
GO:0044212Transcription regulatory region DNA bindingISSmolecular_function
GO:0045893Positive regulation of transcription, DNA-templatedIDAbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIBA ISSbiological_process
GO:0046620Regulation of organ growthIBAbiological_process
GO:0048010Vascular endothelial growth factor receptor signaling pathwayIBAbiological_process
GO:0048343Paraxial mesodermal cell fate commitmentIBAbiological_process
GO:0048703Embryonic viscerocranium morphogenesisIBAbiological_process
GO:0048844Artery morphogenesisIBAbiological_process
GO:0050880Regulation of blood vessel sizeIBAbiological_process
GO:0051090Regulation of sequence-specific DNA binding transcription factor activityIBAbiological_process
GO:0055010Ventricular cardiac muscle tissue morphogenesisIBAbiological_process
GO:0060038Cardiac muscle cell proliferationIBAbiological_process
GO:0072011Glomerular endothelium developmentIEAbiological_process
GO:0072112Glomerular visceral epithelial cell differentiationIEAbiological_process
GO:0072144Glomerular mesangial cell developmentIEAbiological_process
GO:0090050Positive regulation of cell migration involved in sprouting angiogenesisISSbiological_process
GO:1902257Negative regulation of apoptotic process involved in outflow tract morphogenesisIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.93409254210.00450251890.99999024730.1357932571

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.4047344042
GSE13712_SHEARDown-0.1294927530
GSE13712_STATICDown-0.1616054610
GSE19018Down-0.2824119906
GSE19899_A1Down-0.9955868410
GSE19899_A2Down-0.9409555940
PubMed_21979375_A1Down-0.8765738617
PubMed_21979375_A2Down-1.8582249728
GSE35957Down-0.5287932228
GSE36640Down-1.1231447882
GSE54402Down-0.2254137282
GSE9593Down-0.2317717675
GSE43922Down-0.3556780570
GSE24585Up0.1581988420
GSE37065Down-0.1082156782
GSE28863_A1Down-0.3216018994
GSE28863_A2Down-0.0268107666
GSE28863_A3Up0.6961463203
GSE28863_A4Down-0.0198401419
GSE48662Up0.0611535557

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.