HCSGD entry for FOXC2

1. General information

Official gene symbol	FOXC2
Entrez ID	2303
Gene full name	forkhead box C2 (MFH-1, mesenchyme forkhead 1)
Other gene symbols	FKHL14 LD MFH-1 MFH1
Links to Entrez Gene	Links to Entrez Gene

2. Neighbors in the network

This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID	GO term	Evidence	Category
GO:0000122	Negative regulation of transcription from RNA polymerase II promoter	IBA ISS	biological_process
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription	IDA	molecular_function
GO:0001503	Ossification	IBA	biological_process
GO:0001569	Patterning of blood vessels	IBA	biological_process
GO:0001656	Metanephros development	IBA	biological_process
GO:0001657	Ureteric bud development	IBA	biological_process
GO:0001756	Somitogenesis	IBA	biological_process
GO:0001946	Lymphangiogenesis	IMP	biological_process
GO:0001974	Blood vessel remodeling	IBA	biological_process
GO:0003690	Double-stranded DNA binding	IBA	molecular_function
GO:0003700	Sequence-specific DNA binding transcription factor activity	IDA	molecular_function
GO:0003705	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity	IBA	molecular_function
GO:0005634	Nucleus	IDA	cellular_component
GO:0005667	Transcription factor complex	IBA	cellular_component
GO:0006366	Transcription from RNA polymerase II promoter	IBA IDA	biological_process
GO:0007219	Notch signaling pathway	IBA	biological_process
GO:0007498	Mesoderm development	NAS	biological_process
GO:0007507	Heart development	IMP	biological_process
GO:0008134	Transcription factor binding	IBA	molecular_function
GO:0008286	Insulin receptor signaling pathway	IDA	biological_process
GO:0008301	DNA binding, bending	IBA	molecular_function
GO:0009725	Response to hormone	IDA	biological_process
GO:0010595	Positive regulation of endothelial cell migration	ISS	biological_process
GO:0014032	Neural crest cell development	IEA	biological_process
GO:0030199	Collagen fibril organization	IBA	biological_process
GO:0031490	Chromatin DNA binding	IDA	molecular_function
GO:0033630	Positive regulation of cell adhesion mediated by integrin	ISS	biological_process
GO:0035050	Embryonic heart tube development	IBA	biological_process
GO:0035470	Positive regulation of vascular wound healing	ISS	biological_process
GO:0043010	Camera-type eye development	IBA	biological_process
GO:0043066	Negative regulation of apoptotic process	IBA	biological_process
GO:0043565	Sequence-specific DNA binding	IDA	molecular_function
GO:0044212	Transcription regulatory region DNA binding	ISS	molecular_function
GO:0045893	Positive regulation of transcription, DNA-templated	IDA	biological_process
GO:0045944	Positive regulation of transcription from RNA polymerase II promoter	IBA ISS	biological_process
GO:0046620	Regulation of organ growth	IBA	biological_process
GO:0048010	Vascular endothelial growth factor receptor signaling pathway	IBA	biological_process
GO:0048343	Paraxial mesodermal cell fate commitment	IBA	biological_process
GO:0048703	Embryonic viscerocranium morphogenesis	IBA	biological_process
GO:0048844	Artery morphogenesis	IBA	biological_process
GO:0050880	Regulation of blood vessel size	IBA	biological_process
GO:0051090	Regulation of sequence-specific DNA binding transcription factor activity	IBA	biological_process
GO:0055010	Ventricular cardiac muscle tissue morphogenesis	IBA	biological_process
GO:0060038	Cardiac muscle cell proliferation	IBA	biological_process
GO:0072011	Glomerular endothelium development	IEA	biological_process
GO:0072112	Glomerular visceral epithelial cell differentiation	IEA	biological_process
GO:0072144	Glomerular mesangial cell development	IEA	biological_process
GO:0090050	Positive regulation of cell migration involved in sprouting angiogenesis	ISS	biological_process
GO:1902257	Negative regulation of apoptotic process involved in outflow tract morphogenesis	IEA	biological_process

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4. Expression levels in datasets

Meta-analysis result

p-value up	p-value down	FDR up	FDR down
0.9340925421	0.0045025189	0.9999902473	0.1357932571

Individual experiment result
( "-" represent NA in the specific microarray platform )

Data source	Up or down	Log fold change
GSE11954	Down	-0.4047344042
GSE13712_SHEAR	Down	-0.1294927530
GSE13712_STATIC	Down	-0.1616054610
GSE19018	Down	-0.2824119906
GSE19899_A1	Down	-0.9955868410
GSE19899_A2	Down	-0.9409555940
PubMed_21979375_A1	Down	-0.8765738617
PubMed_21979375_A2	Down	-1.8582249728
GSE35957	Down	-0.5287932228
GSE36640	Down	-1.1231447882
GSE54402	Down	-0.2254137282
GSE9593	Down	-0.2317717675
GSE43922	Down	-0.3556780570
GSE24585	Up	0.1581988420
GSE37065	Down	-0.1082156782
GSE28863_A1	Down	-0.3216018994
GSE28863_A2	Down	-0.0268107666
GSE28863_A3	Up	0.6961463203
GSE28863_A4	Down	-0.0198401419
GSE48662	Up	0.0611535557

5. Regulation relationships with compounds/drugs/microRNAs

Compounds

Not regulated by compounds

Drugs

Not regulated by drugs

MicroRNAs

mirTarBase

No target information from mirTarBase

mirRecord

No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.

Navigator

1.General information
2.Neighbors in the network
3.Gene Ontology Annotation
4.Expression levels
5.Regulation
6.Text-mining results