HCSGD entry for FKBP1A

1. General information

Official gene symbolFKBP1A
Entrez ID2280
Gene full nameFK506 binding protein 1A, 12kDa
Other gene symbolsFKBP-12 FKBP-1A FKBP1 FKBP12 PKC12 PKCI2 PPIASE
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000413Protein peptidyl-prolyl isomerizationIDA TASbiological_process
GO:0001933Negative regulation of protein phosphorylationIEAbiological_process
GO:0003007Heart morphogenesisISSbiological_process
GO:0003755Peptidyl-prolyl cis-trans isomerase activityIDA IEA TASmolecular_function
GO:0004871Signal transducer activityIMPmolecular_function
GO:0005024Transforming growth factor beta-activated receptor activityTASmolecular_function
GO:0005160Transforming growth factor beta receptor bindingISSmolecular_function
GO:0005219Ryanodine-sensitive calcium-release channel activityTASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005527Macrolide bindingNASmolecular_function
GO:0005528FK506 bindingIDA NASmolecular_function
GO:0005737CytoplasmIDAcellular_component
GO:0005829CytosolIDA TAScellular_component
GO:0006457Protein foldingIEA NASbiological_process
GO:0006458'de novo' protein foldingTASbiological_process
GO:0006468Protein phosphorylationTASbiological_process
GO:0006936Muscle contractionIEAbiological_process
GO:0007179Transforming growth factor beta receptor signaling pathwayTASbiological_process
GO:0007183SMAD protein complex assemblyIDAbiological_process
GO:0010039Response to iron ionIEAbiological_process
GO:0014802Terminal cisternaISScellular_component
GO:0016020MembraneIDAcellular_component
GO:0016310PhosphorylationTASbiological_process
GO:0018208Peptidyl-proline modificationIBAbiological_process
GO:0019221Cytokine-mediated signaling pathwayIEAbiological_process
GO:0019855Calcium channel inhibitor activityIDAmolecular_function
GO:0019899Enzyme bindingIEAmolecular_function
GO:0022417Protein maturation by protein foldingTASbiological_process
GO:0030018Z discIDAcellular_component
GO:0030424AxonIBAcellular_component
GO:0030544Hsp70 protein bindingIEAmolecular_function
GO:0031000Response to caffeineIEAbiological_process
GO:0031398Positive regulation of protein ubiquitinationIDAbiological_process
GO:0032092Positive regulation of protein bindingIDAbiological_process
GO:0032513Negative regulation of protein phosphatase type 2B activityIDAbiological_process
GO:0032925Regulation of activin receptor signaling pathwayIDAbiological_process
GO:0033017Sarcoplasmic reticulum membraneIBAcellular_component
GO:0034205Beta-amyloid formationIDAbiological_process
GO:0034220Ion transmembrane transportTASbiological_process
GO:0034713Type I transforming growth factor beta receptor bindingISSmolecular_function
GO:0042026Protein refoldingTASbiological_process
GO:0042098T cell proliferationIEAbiological_process
GO:0042110T cell activationNASbiological_process
GO:0043123Positive regulation of I-kappaB kinase/NF-kappaB signalingIMPbiological_process
GO:0043206Extracellular fibril organizationIDAbiological_process
GO:0043679Axon terminusIEAcellular_component
GO:0044325Ion channel bindingISSmolecular_function
GO:0046332SMAD bindingIPImolecular_function
GO:0048185Activin bindingIPImolecular_function
GO:0050776Regulation of immune responseIMPbiological_process
GO:0051209Release of sequestered calcium ion into cytosolIEAbiological_process
GO:0051280Negative regulation of release of sequestered calcium ion into cytosolIDAbiological_process
GO:0055010Ventricular cardiac muscle tissue morphogenesisISSbiological_process
GO:0055085Transmembrane transportTASbiological_process
GO:0060314Regulation of ryanodine-sensitive calcium-release channel activityIDA ISSbiological_process
GO:0060315Negative regulation of ryanodine-sensitive calcium-release channel activityIDAbiological_process
GO:0060347Heart trabecula formationISSbiological_process
GO:0070588Calcium ion transmembrane transportTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.00111178910.96027069260.08950764531.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.3515598799
GSE13712_SHEARUp0.5568880793
GSE13712_STATICUp0.4397743305
GSE19018Up0.5710631970
GSE19899_A1Up1.9919325163
GSE19899_A2Up2.4328909469
PubMed_21979375_A1Up2.0096329419
PubMed_21979375_A2Up1.9451148423
GSE35957Up0.3861005163
GSE36640Up0.0996218836
GSE54402Up0.8482309548
GSE9593Up0.2091444667
GSE43922Up0.6241055354
GSE24585Down-0.2189438208
GSE37065Down-0.0709124202
GSE28863_A1Down-0.6404870393
GSE28863_A2Up0.0250100363
GSE28863_A3Up0.4514128660
GSE28863_A4Down-0.1217981287
GSE48662Down-0.1901769234

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

PimecrolimusDB00337 APRD01182
TacrolimusDB00864 APRD00276 | EXPT01437
SirolimusDB00877 APRD00178 | DB02439
(3r)-4-(P-Toluenesulfonyl)-1,4-Thiazane-3-Carboxylicacid-L-Phenylalanine Ethyl EsterDB01712 EXPT02976
{3-[3-(3,4-Dimethoxy-Phenyl)-1-(1-{1-[2-(3,4,5-Trimethoxy-Phenyl)-Butyryl]-Piperidin-2yl}-Vinyloxy)-Propyl]-Phenoxy}-Acetic AcidDB01723 EXPT00532
Gpi-1046DB01951 EXPT01638
Methyl Methylsulfinylmethyl SulfideDB02311 EXPT01278
FKB-001DB02888 EXPT00001
Heptyl-Beta-D-GlucopyranosideDB03338 EXPT00614
L-709,587DB03621 EXPT00237
(3r)-4-(P-Toluenesulfonyl)-1,4-Thiazane-3-Carboxylicacid-L-LeucineDB04012 EXPT03124
4-Hydroxy-2-ButanoneDB04094 EXPT00777
GPI-1485DB05814 -
MYRISTIC ACIDDB08231 -
(21S)-1AZA-4,4-DIMETHYL-6,19-DIOXA-2,3,7,20-TETRAOXOBICYCLO[19.4.0] PENTACOSANEDB08520 -
6-[4-(2-piperidin-1-ylethoxy)phenyl]-3-pyridin-4-ylpyrazolo[1,5-a]pyrimidineDB08597 -

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-375MIMAT0000728MIRT019913MicroarrayFunctional MTI (Weak)20215506
hsa-miR-103a-3pMIMAT0000101MIRT027184SequencingFunctional MTI (Weak)20371350
hsa-miR-505-5pMIMAT0004776MIRT037938CLASHFunctional MTI (Weak)23622248
hsa-miR-320aMIMAT0000510MIRT044667CLASHFunctional MTI (Weak)23622248
hsa-miR-218-5pMIMAT0000275MIRT046994CLASHFunctional MTI (Weak)23622248
hsa-miR-92a-3pMIMAT0000092MIRT049043CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.