HCSGD entry for FKBP1A

1. General information

Official gene symbolFKBP1A
Entrez ID2280
Gene full nameFK506 binding protein 1A, 12kDa
Other gene symbolsFKBP-12 FKBP-1A FKBP1 FKBP12 PKC12 PKCI2 PPIASE
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000413Protein peptidyl-prolyl isomerizationIDA TASbiological_process
GO:0001933Negative regulation of protein phosphorylationIEAbiological_process
GO:0003007Heart morphogenesisISSbiological_process
GO:0003755Peptidyl-prolyl cis-trans isomerase activityIDA IEA TASmolecular_function
GO:0004871Signal transducer activityIMPmolecular_function
GO:0005024Transforming growth factor beta-activated receptor activityTASmolecular_function
GO:0005160Transforming growth factor beta receptor bindingISSmolecular_function
GO:0005219Ryanodine-sensitive calcium-release channel activityTASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005527Macrolide bindingNASmolecular_function
GO:0005528FK506 bindingIDA NASmolecular_function
GO:0005737CytoplasmIDAcellular_component
GO:0005829CytosolIDA TAScellular_component
GO:0006457Protein foldingIEA NASbiological_process
GO:0006458'de novo' protein foldingTASbiological_process
GO:0006468Protein phosphorylationTASbiological_process
GO:0006936Muscle contractionIEAbiological_process
GO:0007179Transforming growth factor beta receptor signaling pathwayTASbiological_process
GO:0007183SMAD protein complex assemblyIDAbiological_process
GO:0010039Response to iron ionIEAbiological_process
GO:0014802Terminal cisternaISScellular_component
GO:0016020MembraneIDAcellular_component
GO:0016310PhosphorylationTASbiological_process
GO:0018208Peptidyl-proline modificationIBAbiological_process
GO:0019221Cytokine-mediated signaling pathwayIEAbiological_process
GO:0019855Calcium channel inhibitor activityIDAmolecular_function
GO:0019899Enzyme bindingIEAmolecular_function
GO:0022417Protein maturation by protein foldingTASbiological_process
GO:0030018Z discIDAcellular_component
GO:0030424AxonIBAcellular_component
GO:0030544Hsp70 protein bindingIEAmolecular_function
GO:0031000Response to caffeineIEAbiological_process
GO:0031398Positive regulation of protein ubiquitinationIDAbiological_process
GO:0032092Positive regulation of protein bindingIDAbiological_process
GO:0032513Negative regulation of protein phosphatase type 2B activityIDAbiological_process
GO:0032925Regulation of activin receptor signaling pathwayIDAbiological_process
GO:0033017Sarcoplasmic reticulum membraneIBAcellular_component
GO:0034205Beta-amyloid formationIDAbiological_process
GO:0034220Ion transmembrane transportTASbiological_process
GO:0034713Type I transforming growth factor beta receptor bindingISSmolecular_function
GO:0042026Protein refoldingTASbiological_process
GO:0042098T cell proliferationIEAbiological_process
GO:0042110T cell activationNASbiological_process
GO:0043123Positive regulation of I-kappaB kinase/NF-kappaB signalingIMPbiological_process
GO:0043206Extracellular fibril organizationIDAbiological_process
GO:0043679Axon terminusIEAcellular_component
GO:0044325Ion channel bindingISSmolecular_function
GO:0046332SMAD bindingIPImolecular_function
GO:0048185Activin bindingIPImolecular_function
GO:0050776Regulation of immune responseIMPbiological_process
GO:0051209Release of sequestered calcium ion into cytosolIEAbiological_process
GO:0051280Negative regulation of release of sequestered calcium ion into cytosolIDAbiological_process
GO:0055010Ventricular cardiac muscle tissue morphogenesisISSbiological_process
GO:0055085Transmembrane transportTASbiological_process
GO:0060314Regulation of ryanodine-sensitive calcium-release channel activityIDA ISSbiological_process
GO:0060315Negative regulation of ryanodine-sensitive calcium-release channel activityIDAbiological_process
GO:0060347Heart trabecula formationISSbiological_process
GO:0070588Calcium ion transmembrane transportTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.00111178910.96027069260.08950764531.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.3515598799
GSE13712_SHEARUp0.5568880793
GSE13712_STATICUp0.4397743305
GSE19018Up0.5710631970
GSE19899_A1Up1.9919325163
GSE19899_A2Up2.4328909469
PubMed_21979375_A1Up2.0096329419
PubMed_21979375_A2Up1.9451148423
GSE35957Up0.3861005163
GSE36640Up0.0996218836
GSE54402Up0.8482309548
GSE9593Up0.2091444667
GSE43922Up0.6241055354
GSE24585Down-0.2189438208
GSE37065Down-0.0709124202
GSE28863_A1Down-0.6404870393
GSE28863_A2Up0.0250100363
GSE28863_A3Up0.4514128660
GSE28863_A4Down-0.1217981287
GSE48662Down-0.1901769234

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

PimecrolimusDB00337 APRD01182
TacrolimusDB00864 APRD00276 | EXPT01437
SirolimusDB00877 APRD00178 | DB02439
(3r)-4-(P-Toluenesulfonyl)-1,4-Thiazane-3-Carboxylicacid-L-Phenylalanine Ethyl EsterDB01712 EXPT02976
{3-[3-(3,4-Dimethoxy-Phenyl)-1-(1-{1-[2-(3,4,5-Trimethoxy-Phenyl)-Butyryl]-Piperidin-2yl}-Vinyloxy)-Propyl]-Phenoxy}-Acetic AcidDB01723 EXPT00532
Gpi-1046DB01951 EXPT01638
Methyl Methylsulfinylmethyl SulfideDB02311 EXPT01278
FKB-001DB02888 EXPT00001
Heptyl-Beta-D-GlucopyranosideDB03338 EXPT00614
L-709,587DB03621 EXPT00237
(3r)-4-(P-Toluenesulfonyl)-1,4-Thiazane-3-Carboxylicacid-L-LeucineDB04012 EXPT03124
4-Hydroxy-2-ButanoneDB04094 EXPT00777
GPI-1485DB05814 -
MYRISTIC ACIDDB08231 -
(21S)-1AZA-4,4-DIMETHYL-6,19-DIOXA-2,3,7,20-TETRAOXOBICYCLO[19.4.0] PENTACOSANEDB08520 -
6-[4-(2-piperidin-1-ylethoxy)phenyl]-3-pyridin-4-ylpyrazolo[1,5-a]pyrimidineDB08597 -

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-375MIMAT0000728MIRT019913MicroarrayFunctional MTI (Weak)20215506
hsa-miR-103a-3pMIMAT0000101MIRT027184SequencingFunctional MTI (Weak)20371350
hsa-miR-505-5pMIMAT0004776MIRT037938CLASHFunctional MTI (Weak)23622248
hsa-miR-320aMIMAT0000510MIRT044667CLASHFunctional MTI (Weak)23622248
hsa-miR-218-5pMIMAT0000275MIRT046994CLASHFunctional MTI (Weak)23622248
hsa-miR-92a-3pMIMAT0000092MIRT049043CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.