HCSGD entry for FGFR4

1. General information

Official gene symbolFGFR4
Entrez ID2264
Gene full namefibroblast growth factor receptor 4
Other gene symbolsCD334 JTK2 TKF
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001759Organ inductionIEAbiological_process
GO:0004713Protein tyrosine kinase activityIEA TASmolecular_function
GO:0005007Fibroblast growth factor-activated receptor activityIDA IEA IGImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005576Extracellular regionIEAcellular_component
GO:0005634NucleusIDAcellular_component
GO:0005730NucleolusIDAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005768EndosomeIEAcellular_component
GO:0005783Endoplasmic reticulumIDAcellular_component
GO:0005886Plasma membraneTAScellular_component
GO:0005887Integral component of plasma membraneIDAcellular_component
GO:0005911Cell-cell junctionIDAcellular_component
GO:0007173Epidermal growth factor receptor signaling pathwayTASbiological_process
GO:0008201Heparin bindingIDAmolecular_function
GO:0008284Positive regulation of cell proliferationIDA IEA IGIbiological_process
GO:0008286Insulin receptor signaling pathwayTASbiological_process
GO:0008543Fibroblast growth factor receptor signaling pathwayIDA IGI IPI TASbiological_process
GO:0010715Regulation of extracellular matrix disassemblyIMPbiological_process
GO:0016021Integral component of membraneIEAcellular_component
GO:0016477Cell migrationIMPbiological_process
GO:0017134Fibroblast growth factor bindingIDA IPImolecular_function
GO:0018108Peptidyl-tyrosine phosphorylationIDAbiological_process
GO:0019216Regulation of lipid metabolic processISSbiological_process
GO:0038095Fc-epsilon receptor signaling pathwayTASbiological_process
GO:0042593Glucose homeostasisIEA ISSbiological_process
GO:0045087Innate immune responseTASbiological_process
GO:0045862Positive regulation of proteolysisIMPbiological_process
GO:0046777Protein autophosphorylationIDAbiological_process
GO:0048011Neurotrophin TRK receptor signaling pathwayTASbiological_process
GO:0048015Phosphatidylinositol-mediated signalingTASbiological_process
GO:0048554Positive regulation of metalloenzyme activityIMPbiological_process
GO:0055062Phosphate ion homeostasisIEA ISSbiological_process
GO:0061144Alveolar secondary septum developmentIEAbiological_process
GO:0070374Positive regulation of ERK1 and ERK2 cascadeIMPbiological_process
GO:0070857Regulation of bile acid biosynthetic processIEA IMPbiological_process
GO:2000188Regulation of cholesterol homeostasisIEA ISSbiological_process
GO:2000573Positive regulation of DNA biosynthetic processIMPbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.63127900920.57337433990.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0258035336
GSE13712_SHEARUp0.0162944929
GSE13712_STATICDown-0.1563603913
GSE19018Up0.0692153473
GSE19899_A1Down-0.1241949035
GSE19899_A2Down-0.0309295471
PubMed_21979375_A1Up0.1111311269
PubMed_21979375_A2Down-0.0918560682
GSE35957Up0.0957026076
GSE36640Up0.0342952376
GSE54402Down-0.1582749649
GSE9593Down-0.1025114002
GSE43922Up0.0649345723
GSE24585Down-0.3723440407
GSE37065Down-0.0680616481
GSE28863_A1Down-0.1846045857
GSE28863_A2Up0.0108726366
GSE28863_A3Up0.3868512621
GSE28863_A4Up0.1845007441
GSE48662Up0.7269146814

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

PaliferminDB00039 BTD00042 | BIOD00042
PonatinibDB08901 -
LenvatinibDB09078 -

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.