HCSGD entry for FGFR4

1. General information

Official gene symbolFGFR4
Entrez ID2264
Gene full namefibroblast growth factor receptor 4
Other gene symbolsCD334 JTK2 TKF
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001759Organ inductionIEAbiological_process
GO:0004713Protein tyrosine kinase activityIEA TASmolecular_function
GO:0005007Fibroblast growth factor-activated receptor activityIDA IEA IGImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005576Extracellular regionIEAcellular_component
GO:0005634NucleusIDAcellular_component
GO:0005730NucleolusIDAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005768EndosomeIEAcellular_component
GO:0005783Endoplasmic reticulumIDAcellular_component
GO:0005886Plasma membraneTAScellular_component
GO:0005887Integral component of plasma membraneIDAcellular_component
GO:0005911Cell-cell junctionIDAcellular_component
GO:0007173Epidermal growth factor receptor signaling pathwayTASbiological_process
GO:0008201Heparin bindingIDAmolecular_function
GO:0008284Positive regulation of cell proliferationIDA IEA IGIbiological_process
GO:0008286Insulin receptor signaling pathwayTASbiological_process
GO:0008543Fibroblast growth factor receptor signaling pathwayIDA IGI IPI TASbiological_process
GO:0010715Regulation of extracellular matrix disassemblyIMPbiological_process
GO:0016021Integral component of membraneIEAcellular_component
GO:0016477Cell migrationIMPbiological_process
GO:0017134Fibroblast growth factor bindingIDA IPImolecular_function
GO:0018108Peptidyl-tyrosine phosphorylationIDAbiological_process
GO:0019216Regulation of lipid metabolic processISSbiological_process
GO:0038095Fc-epsilon receptor signaling pathwayTASbiological_process
GO:0042593Glucose homeostasisIEA ISSbiological_process
GO:0045087Innate immune responseTASbiological_process
GO:0045862Positive regulation of proteolysisIMPbiological_process
GO:0046777Protein autophosphorylationIDAbiological_process
GO:0048011Neurotrophin TRK receptor signaling pathwayTASbiological_process
GO:0048015Phosphatidylinositol-mediated signalingTASbiological_process
GO:0048554Positive regulation of metalloenzyme activityIMPbiological_process
GO:0055062Phosphate ion homeostasisIEA ISSbiological_process
GO:0061144Alveolar secondary septum developmentIEAbiological_process
GO:0070374Positive regulation of ERK1 and ERK2 cascadeIMPbiological_process
GO:0070857Regulation of bile acid biosynthetic processIEA IMPbiological_process
GO:2000188Regulation of cholesterol homeostasisIEA ISSbiological_process
GO:2000573Positive regulation of DNA biosynthetic processIMPbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.63127900920.57337433990.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0258035336
GSE13712_SHEARUp0.0162944929
GSE13712_STATICDown-0.1563603913
GSE19018Up0.0692153473
GSE19899_A1Down-0.1241949035
GSE19899_A2Down-0.0309295471
PubMed_21979375_A1Up0.1111311269
PubMed_21979375_A2Down-0.0918560682
GSE35957Up0.0957026076
GSE36640Up0.0342952376
GSE54402Down-0.1582749649
GSE9593Down-0.1025114002
GSE43922Up0.0649345723
GSE24585Down-0.3723440407
GSE37065Down-0.0680616481
GSE28863_A1Down-0.1846045857
GSE28863_A2Up0.0108726366
GSE28863_A3Up0.3868512621
GSE28863_A4Up0.1845007441
GSE48662Up0.7269146814

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

PaliferminDB00039 BTD00042 | BIOD00042
PonatinibDB08901 -
LenvatinibDB09078 -

  • MicroRNAs

  • mirTarBase
No target information from mirTarBase
  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.