HCSGD entry for ACSL4

1. General information

Official gene symbolACSL4
Entrez ID2182
Gene full nameacyl-CoA synthetase long-chain family member 4
Other gene symbolsACS4 FACL4 LACS4 MRX63 MRX68
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001676Long-chain fatty acid metabolic processIDAbiological_process
GO:0003824Catalytic activityIEAmolecular_function
GO:0004467Long-chain fatty acid-CoA ligase activityIDA IEAmolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005737CytoplasmIDAcellular_component
GO:0005741Mitochondrial outer membraneIEAcellular_component
GO:0005777PeroxisomeIEAcellular_component
GO:0005778Peroxisomal membraneIEAcellular_component
GO:0005789Endoplasmic reticulum membraneTAScellular_component
GO:0005811Lipid particleIDAcellular_component
GO:0006629Lipid metabolic processIDAbiological_process
GO:0006641Triglyceride metabolic processIEAbiological_process
GO:0007584Response to nutrientIEAbiological_process
GO:0008610Lipid biosynthetic processIDAbiological_process
GO:0015908Fatty acid transportIEAbiological_process
GO:0016021Integral component of membraneIEAcellular_component
GO:0019432Triglyceride biosynthetic processTASbiological_process
GO:0030307Positive regulation of cell growthIDAbiological_process
GO:0031957Very long-chain fatty acid-CoA ligase activityIMPmolecular_function
GO:0031966Mitochondrial membraneIEAcellular_component
GO:0032307Negative regulation of prostaglandin secretionIDAbiological_process
GO:0035338Long-chain fatty-acyl-CoA biosynthetic processTASbiological_process
GO:0043025Neuronal cell bodyIEAcellular_component
GO:0044255Cellular lipid metabolic processTASbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0047676Arachidonate-CoA ligase activityIDAmolecular_function
GO:0060136Embryonic process involved in female pregnancyIEAbiological_process
GO:0060996Dendritic spine developmentIEAbiological_process
GO:0070672Response to interleukin-15IEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.21932055010.17802756730.90072671240.8159391365

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.2841433079
GSE13712_SHEARUp0.4649871632
GSE13712_STATICUp0.2426910669
GSE19018Down-0.4140485456
GSE19899_A1Up0.2766610898
GSE19899_A2Up0.1953551535
PubMed_21979375_A1Up0.2502266909
PubMed_21979375_A2Up0.0804346057
GSE35957Down-0.2117793741
GSE36640Down-0.4232116957
GSE54402Up0.4553066202
GSE9593Down-0.1536536094
GSE43922Up0.0847421741
GSE24585Down-0.4991575221
GSE37065Up0.5267672398
GSE28863_A1Up0.2473244855
GSE28863_A2Up0.1344837681
GSE28863_A3Down-0.2841863727
GSE28863_A4Up0.0108155543
GSE48662Down-0.5922870030

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

TroglitazoneDB00197 APRD00488
RosiglitazoneDB00412 APRD00403

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-375MIMAT0000728MIRT020060MicroarrayFunctional MTI (Weak)20215506
hsa-miR-34a-5pMIMAT0000255MIRT025215Proteomics//Reporter assay;ProteomicsFunctional MTI21566225
hsa-miR-30a-5pMIMAT0000087MIRT028658ProteomicsFunctional MTI (Weak)18668040
hsa-miR-378a-3pMIMAT0000732MIRT043925CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.