HCSGD entry for ACSL4

1. General information

Official gene symbolACSL4
Entrez ID2182
Gene full nameacyl-CoA synthetase long-chain family member 4
Other gene symbolsACS4 FACL4 LACS4 MRX63 MRX68
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001676Long-chain fatty acid metabolic processIDAbiological_process
GO:0003824Catalytic activityIEAmolecular_function
GO:0004467Long-chain fatty acid-CoA ligase activityIDA IEAmolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005737CytoplasmIDAcellular_component
GO:0005741Mitochondrial outer membraneIEAcellular_component
GO:0005777PeroxisomeIEAcellular_component
GO:0005778Peroxisomal membraneIEAcellular_component
GO:0005789Endoplasmic reticulum membraneTAScellular_component
GO:0005811Lipid particleIDAcellular_component
GO:0006629Lipid metabolic processIDAbiological_process
GO:0006641Triglyceride metabolic processIEAbiological_process
GO:0007584Response to nutrientIEAbiological_process
GO:0008610Lipid biosynthetic processIDAbiological_process
GO:0015908Fatty acid transportIEAbiological_process
GO:0016021Integral component of membraneIEAcellular_component
GO:0019432Triglyceride biosynthetic processTASbiological_process
GO:0030307Positive regulation of cell growthIDAbiological_process
GO:0031957Very long-chain fatty acid-CoA ligase activityIMPmolecular_function
GO:0031966Mitochondrial membraneIEAcellular_component
GO:0032307Negative regulation of prostaglandin secretionIDAbiological_process
GO:0035338Long-chain fatty-acyl-CoA biosynthetic processTASbiological_process
GO:0043025Neuronal cell bodyIEAcellular_component
GO:0044255Cellular lipid metabolic processTASbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0047676Arachidonate-CoA ligase activityIDAmolecular_function
GO:0060136Embryonic process involved in female pregnancyIEAbiological_process
GO:0060996Dendritic spine developmentIEAbiological_process
GO:0070672Response to interleukin-15IEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.21932055010.17802756730.90072671240.8159391365

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.2841433079
GSE13712_SHEARUp0.4649871632
GSE13712_STATICUp0.2426910669
GSE19018Down-0.4140485456
GSE19899_A1Up0.2766610898
GSE19899_A2Up0.1953551535
PubMed_21979375_A1Up0.2502266909
PubMed_21979375_A2Up0.0804346057
GSE35957Down-0.2117793741
GSE36640Down-0.4232116957
GSE54402Up0.4553066202
GSE9593Down-0.1536536094
GSE43922Up0.0847421741
GSE24585Down-0.4991575221
GSE37065Up0.5267672398
GSE28863_A1Up0.2473244855
GSE28863_A2Up0.1344837681
GSE28863_A3Down-0.2841863727
GSE28863_A4Up0.0108155543
GSE48662Down-0.5922870030

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

TroglitazoneDB00197 APRD00488
RosiglitazoneDB00412 APRD00403

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-375MIMAT0000728MIRT020060MicroarrayFunctional MTI (Weak)20215506
hsa-miR-34a-5pMIMAT0000255MIRT025215Proteomics//Reporter assay;ProteomicsFunctional MTI21566225
hsa-miR-30a-5pMIMAT0000087MIRT028658ProteomicsFunctional MTI (Weak)18668040
hsa-miR-378a-3pMIMAT0000732MIRT043925CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.