HCSGD entry for F8

1. General information

Official gene symbolF8
Entrez ID2157
Gene full namecoagulation factor VIII, procoagulant component
Other gene symbolsAHF DXS1253E F8B F8C FVIII HEMA
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0002576Platelet degranulationTASbiological_process
GO:0004252Serine-type endopeptidase activityIEAmolecular_function
GO:0005507Copper ion bindingIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005576Extracellular regionNAS TAScellular_component
GO:0005615Extracellular spaceIEAcellular_component
GO:0005886Plasma membraneTAScellular_component
GO:0006953Acute-phase responseIEAbiological_process
GO:0007155Cell adhesionIEAbiological_process
GO:0007596Blood coagulationTASbiological_process
GO:0007597Blood coagulation, intrinsic pathwayTASbiological_process
GO:0016491Oxidoreductase activityIEAmolecular_function
GO:0030168Platelet activationTASbiological_process
GO:0031093Platelet alpha granule lumenTAScellular_component
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.11380256070.58313270010.69391450081.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0634489872
GSE13712_SHEARUp0.2815226123
GSE13712_STATICUp0.6247193899
GSE19018Down-0.0327870515
GSE19899_A1Up0.1244461831
GSE19899_A2Down-0.1927139284
PubMed_21979375_A1Down-0.1865017837
PubMed_21979375_A2Up0.3238882156
GSE35957Up0.0983501408
GSE36640Up0.0000256219
GSE54402Down-0.3052476023
GSE9593Up0.5892737179
GSE43922Up0.0244253065
GSE24585Up0.6232566867
GSE37065Up0.1199564793
GSE28863_A1Down-0.2847937431
GSE28863_A2Up0.0075018719
GSE28863_A3Down-0.0966020273
GSE28863_A4Up0.0002519806
GSE48662Up0.2757931484

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

Coagulation Factor IX (Recombinant)DB00100 BTD00038 | BIOD00038

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.