HCSGD entry for F2RL1

1. General information

Official gene symbolF2RL1
Entrez ID2150
Gene full namecoagulation factor II (thrombin) receptor-like 1
Other gene symbolsGPR11 PAR2
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001965G-protein alpha-subunit bindingIEA ISSmolecular_function
GO:0002286T cell activation involved in immune responseIEA ISSbiological_process
GO:0002690Positive regulation of leukocyte chemotaxisIDAbiological_process
GO:0002741Positive regulation of cytokine secretion involved in immune responseIDAbiological_process
GO:0003104Positive regulation of glomerular filtrationIEA ISSbiological_process
GO:0004872Receptor activityTASmolecular_function
GO:0004930G-protein coupled receptor activityIMP ISSmolecular_function
GO:0005102Receptor bindingTASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005794Golgi apparatusTAScellular_component
GO:0005886Plasma membraneTAScellular_component
GO:0005887Integral component of plasma membraneIDAcellular_component
GO:0006954Inflammatory responseIEAbiological_process
GO:0007186G-protein coupled receptor signaling pathwayTASbiological_process
GO:0007204Positive regulation of cytosolic calcium ion concentrationIDA IEA ISSbiological_process
GO:0007596Blood coagulationIEAbiological_process
GO:0010804Negative regulation of tumor necrosis factor-mediated signaling pathwayIDAbiological_process
GO:0014068Positive regulation of phosphatidylinositol 3-kinase signalingIEA ISSbiological_process
GO:0015057Thrombin receptor activityIEAmolecular_function
GO:0016021Integral component of membraneIEAcellular_component
GO:0030193Regulation of blood coagulationIDAbiological_process
GO:0030335Positive regulation of cell migrationIEA ISSbiological_process
GO:0030836Positive regulation of actin filament depolymerizationIDAbiological_process
GO:0031143PseudopodiumIEA ISScellular_component
GO:0031274Positive regulation of pseudopodium assemblyIEA ISSbiological_process
GO:0031681G-protein beta-subunit bindingIEA ISSmolecular_function
GO:0032930Positive regulation of superoxide anion generationIDAbiological_process
GO:0034137Positive regulation of toll-like receptor 2 signaling pathwayIMPbiological_process
GO:0034140Negative regulation of toll-like receptor 3 signaling pathwayIMPbiological_process
GO:0034141Positive regulation of toll-like receptor 3 signaling pathwayIMPbiological_process
GO:0034145Positive regulation of toll-like receptor 4 signaling pathwayIDAbiological_process
GO:0035025Positive regulation of Rho protein signal transductionIEA IMP ISSbiological_process
GO:0035926Chemokine (C-C motif) ligand 2 secretionIDAbiological_process
GO:0042119Neutrophil activationIDAbiological_process
GO:0043122Regulation of I-kappaB kinase/NF-kappaB signalingIDAbiological_process
GO:0043123Positive regulation of I-kappaB kinase/NF-kappaB signalingIDAbiological_process
GO:0043311Positive regulation of eosinophil degranulationIDAbiological_process
GO:0045087Innate immune responseIEAbiological_process
GO:0045909Positive regulation of vasodilationIEA ISSbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIDAbiological_process
GO:0046328Regulation of JNK cascadeIDAbiological_process
GO:0046329Negative regulation of JNK cascadeIDAbiological_process
GO:0046330Positive regulation of JNK cascadeIDAbiological_process
GO:0050702Interleukin-1 beta secretionIDAbiological_process
GO:0050900Leukocyte migrationIDAbiological_process
GO:0050921Positive regulation of chemotaxisIEA ISSbiological_process
GO:0050927Positive regulation of positive chemotaxisIDAbiological_process
GO:0051607Defense response to virusIDA IEAbiological_process
GO:0060100Positive regulation of phagocytosis, engulfmentIDAbiological_process
GO:0061028Establishment of endothelial barrierIDAbiological_process
GO:0070374Positive regulation of ERK1 and ERK2 cascadeIDA IEA ISSbiological_process
GO:0070661Leukocyte proliferationIEA ISSbiological_process
GO:0070963Positive regulation of neutrophil mediated killing of gram-negative bacteriumIDAbiological_process
GO:0072608Interleukin-10 secretionIDAbiological_process
GO:0072643Interferon-gamma secretionIEA ISSbiological_process
GO:0090195Chemokine secretionIDA IEAbiological_process
GO:0090198Negative regulation of chemokine secretionIDAbiological_process
GO:0097029Mature dendritic cell differentiationIDA IEA ISSbiological_process
GO:1900135Positive regulation of renin secretion into blood streamIEA ISSbiological_process
GO:2000484Positive regulation of interleukin-8 secretionIDAbiological_process
GO:2000778Positive regulation of interleukin-6 secretionIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.00014855440.30910033810.03507699121.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up1.2787506283
GSE13712_SHEARUp2.3842973098
GSE13712_STATICUp0.9968516764
GSE19018Down-0.3730323046
GSE19899_A1Up4.2325172968
GSE19899_A2Up1.9126577503
PubMed_21979375_A1Up2.4602206068
PubMed_21979375_A2Up3.0831411279
GSE35957Down-0.8399911881
GSE36640Down-2.6971264546
GSE54402Up3.3913620846
GSE9593Up0.1278693474
GSE43922Up2.3416034491
GSE24585Down-0.2500528495
GSE37065Up0.1707926387
GSE28863_A1Down-0.0082663821
GSE28863_A2Down-0.1122014396
GSE28863_A3Up0.0068050476
GSE28863_A4Down-0.1081551862
GSE48662Down-0.5491565896

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-1MIMAT0000416MIRT023577MicroarrayFunctional MTI (Weak)18668037
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.