HCSGD entry for F2RL1

1. General information

Official gene symbolF2RL1
Entrez ID2150
Gene full namecoagulation factor II (thrombin) receptor-like 1
Other gene symbolsGPR11 PAR2
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001965G-protein alpha-subunit bindingIEA ISSmolecular_function
GO:0002286T cell activation involved in immune responseIEA ISSbiological_process
GO:0002690Positive regulation of leukocyte chemotaxisIDAbiological_process
GO:0002741Positive regulation of cytokine secretion involved in immune responseIDAbiological_process
GO:0003104Positive regulation of glomerular filtrationIEA ISSbiological_process
GO:0004872Receptor activityTASmolecular_function
GO:0004930G-protein coupled receptor activityIMP ISSmolecular_function
GO:0005102Receptor bindingTASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005794Golgi apparatusTAScellular_component
GO:0005886Plasma membraneTAScellular_component
GO:0005887Integral component of plasma membraneIDAcellular_component
GO:0006954Inflammatory responseIEAbiological_process
GO:0007186G-protein coupled receptor signaling pathwayTASbiological_process
GO:0007204Positive regulation of cytosolic calcium ion concentrationIDA IEA ISSbiological_process
GO:0007596Blood coagulationIEAbiological_process
GO:0010804Negative regulation of tumor necrosis factor-mediated signaling pathwayIDAbiological_process
GO:0014068Positive regulation of phosphatidylinositol 3-kinase signalingIEA ISSbiological_process
GO:0015057Thrombin receptor activityIEAmolecular_function
GO:0016021Integral component of membraneIEAcellular_component
GO:0030193Regulation of blood coagulationIDAbiological_process
GO:0030335Positive regulation of cell migrationIEA ISSbiological_process
GO:0030836Positive regulation of actin filament depolymerizationIDAbiological_process
GO:0031143PseudopodiumIEA ISScellular_component
GO:0031274Positive regulation of pseudopodium assemblyIEA ISSbiological_process
GO:0031681G-protein beta-subunit bindingIEA ISSmolecular_function
GO:0032930Positive regulation of superoxide anion generationIDAbiological_process
GO:0034137Positive regulation of toll-like receptor 2 signaling pathwayIMPbiological_process
GO:0034140Negative regulation of toll-like receptor 3 signaling pathwayIMPbiological_process
GO:0034141Positive regulation of toll-like receptor 3 signaling pathwayIMPbiological_process
GO:0034145Positive regulation of toll-like receptor 4 signaling pathwayIDAbiological_process
GO:0035025Positive regulation of Rho protein signal transductionIEA IMP ISSbiological_process
GO:0035926Chemokine (C-C motif) ligand 2 secretionIDAbiological_process
GO:0042119Neutrophil activationIDAbiological_process
GO:0043122Regulation of I-kappaB kinase/NF-kappaB signalingIDAbiological_process
GO:0043123Positive regulation of I-kappaB kinase/NF-kappaB signalingIDAbiological_process
GO:0043311Positive regulation of eosinophil degranulationIDAbiological_process
GO:0045087Innate immune responseIEAbiological_process
GO:0045909Positive regulation of vasodilationIEA ISSbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterIDAbiological_process
GO:0046328Regulation of JNK cascadeIDAbiological_process
GO:0046329Negative regulation of JNK cascadeIDAbiological_process
GO:0046330Positive regulation of JNK cascadeIDAbiological_process
GO:0050702Interleukin-1 beta secretionIDAbiological_process
GO:0050900Leukocyte migrationIDAbiological_process
GO:0050921Positive regulation of chemotaxisIEA ISSbiological_process
GO:0050927Positive regulation of positive chemotaxisIDAbiological_process
GO:0051607Defense response to virusIDA IEAbiological_process
GO:0060100Positive regulation of phagocytosis, engulfmentIDAbiological_process
GO:0061028Establishment of endothelial barrierIDAbiological_process
GO:0070374Positive regulation of ERK1 and ERK2 cascadeIDA IEA ISSbiological_process
GO:0070661Leukocyte proliferationIEA ISSbiological_process
GO:0070963Positive regulation of neutrophil mediated killing of gram-negative bacteriumIDAbiological_process
GO:0072608Interleukin-10 secretionIDAbiological_process
GO:0072643Interferon-gamma secretionIEA ISSbiological_process
GO:0090195Chemokine secretionIDA IEAbiological_process
GO:0090198Negative regulation of chemokine secretionIDAbiological_process
GO:0097029Mature dendritic cell differentiationIDA IEA ISSbiological_process
GO:1900135Positive regulation of renin secretion into blood streamIEA ISSbiological_process
GO:2000484Positive regulation of interleukin-8 secretionIDAbiological_process
GO:2000778Positive regulation of interleukin-6 secretionIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.00014855440.30910033810.03507699121.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up1.2787506283
GSE13712_SHEARUp2.3842973098
GSE13712_STATICUp0.9968516764
GSE19018Down-0.3730323046
GSE19899_A1Up4.2325172968
GSE19899_A2Up1.9126577503
PubMed_21979375_A1Up2.4602206068
PubMed_21979375_A2Up3.0831411279
GSE35957Down-0.8399911881
GSE36640Down-2.6971264546
GSE54402Up3.3913620846
GSE9593Up0.1278693474
GSE43922Up2.3416034491
GSE24585Down-0.2500528495
GSE37065Up0.1707926387
GSE28863_A1Down-0.0082663821
GSE28863_A2Down-0.1122014396
GSE28863_A3Up0.0068050476
GSE28863_A4Down-0.1081551862
GSE48662Down-0.5491565896

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-1MIMAT0000416MIRT023577MicroarrayFunctional MTI (Weak)18668037
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.