HCSGD entry for EWSR1


1. General information

Official gene symbolEWSR1
Entrez ID2130
Gene full nameEWS RNA-binding protein 1
Other gene symbolsEWS bK984G1.4
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000166Nucleotide bindingIEAmolecular_function
GO:0003676Nucleic acid bindingIEAmolecular_function
GO:0003723RNA bindingIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005516Calmodulin bindingIEAmolecular_function
GO:0005634NucleusIEAcellular_component
GO:0005737CytoplasmIEAcellular_component
GO:0005886Plasma membraneIEAcellular_component
GO:0006351Transcription, DNA-templatedIEAbiological_process
GO:0006355Regulation of transcription, DNA-templatedIEAbiological_process
GO:0008270Zinc ion bindingIEAmolecular_function
GO:0042802Identical protein bindingIPImolecular_function
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.97987399030.08852385930.99999024730.5644834867

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.1764775960
GSE13712_SHEARUp0.1541773296
GSE13712_STATICDown-0.0651524177
GSE19018Down-0.2645022478
GSE19899_A1Down-0.1833212480
GSE19899_A2Down-0.2363531845
PubMed_21979375_A1Down-1.2462533918
PubMed_21979375_A2Down-0.5173374779
GSE35957Down-0.3022070438
GSE36640Down-0.1645634695
GSE54402Down-0.1375073007
GSE9593Down-0.3209026868
GSE43922Up0.0043701658
GSE24585Up0.0758369788
GSE37065Up0.0396409626
GSE28863_A1Up0.0186683822
GSE28863_A2Up0.1538130520
GSE28863_A3Down-0.1282539021
GSE28863_A4Up0.0032808265
GSE48662Down-0.0508424618

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-877-3pMIMAT0004950MIRT037136CLASHFunctional MTI (Weak)23622248
hsa-miR-615-3pMIMAT0003283MIRT040046CLASHFunctional MTI (Weak)23622248
hsa-miR-423-3pMIMAT0001340MIRT042515CLASHFunctional MTI (Weak)23622248
hsa-miR-328-3pMIMAT0000752MIRT043753CLASHFunctional MTI (Weak)23622248
hsa-miR-362-5pMIMAT0000705MIRT044051CLASHFunctional MTI (Weak)23622248
hsa-miR-320aMIMAT0000510MIRT044493CLASHFunctional MTI (Weak)23622248
hsa-miR-149-5pMIMAT0000450MIRT045611CLASHFunctional MTI (Weak)23622248
hsa-miR-23b-3pMIMAT0000418MIRT046333CLASHFunctional MTI (Weak)23622248
hsa-miR-196a-5pMIMAT0000226MIRT048183CLASHFunctional MTI (Weak)23622248
hsa-miR-100-5pMIMAT0000098MIRT048593CLASHFunctional MTI (Weak)23622248
hsa-let-7c-5pMIMAT0000064MIRT051778CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 4 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

21030557Ewing sarcoma gene Ews regulates hematopoietic stem cell senescence
21030557Here, we demonstrated that endogenous Ewing sarcoma gene (Ews) is indispensable for stem cell quiescence, and that the ablation of Ews promotes the early onset of senescence in hematopoietic stem progenitor cells
21030557With its relevance to cancer and possibly aging, EWS is likely to play a significant role in maintaining the functional capacity of stem cells and may provide further insight into the complexity of Ewing sarcoma in the context of stem cells
19133275The Ewing sarcoma (EWS) protein is a member of a large family of RNA-binding proteins
19133275Chimeric EWS oncoproteins generated by chromosomal translocations between the EWS protein and several transcription factors cause various malignant tumors
19133275Due to its multifunctional properties, the EWS protein is involved in such processes as meiotic DNA pairing/recombination, cellular senescence, gene expression, RNA processing and transport, and cell signaling
19133275The EWS protein is predominantly located in the nucleus
19133275In this study, analysis of the localization of endogenous and fluorescently labeled recombinant EWS protein in different phases of the cell cycle in different cell lines revealed a very dynamic subcellular distribution of the EWS protein
19133275In Cos7 and HeLa cells, an association of the EWS protein with the centrosomal compartments was shown
19133275As an outlook, the present findings provide an important insight into temporally and spatially regulated functions of the EWS protein and, particularly, into its role in the regulation of the cell cycle and possibly cell differentiation
18271016EWS/FLI1 suppresses retinoblastoma protein function and senescence in Ewing's sarcoma cells
18271016Ewing's Family Tumors (EFTs) most commonly harbor a specific t(11;22) translocation that generates the EWS/FLI1 fusion protein responsible for malignant transformation
18271016Many potential downstream targets of EWS/FLI1 have been identified but a detailed mechanism by which the fusion protein brings about transformation remains unknown
18271016In this report, we show that depletion of EWS/FLI1 in Ewing's cell lines results in a senescence phenotype, a marked increase in expression of the G1/S regulatory proteins p27(kip1) and p57(kip2), and a significant decrease in cyclin D1 and CDK2
18271016We also demonstrate for the first time, to our knowledge, that knockdown of EWS/FLI1 leads to hypophosphorylation and functional activation of the retinoblastoma (pRb) family of proteins
18271016Together, these results support the role of EWS/LI1 as an inhibitor of cellular senescence and implicate the retinoblastoma family of proteins as key mediators of this inhibition
17415412Ewing sarcoma gene EWS is essential for meiosis and B lymphocyte development
17415412Ewing sarcoma gene EWS encodes a putative RNA-binding protein with proposed roles in transcription and splicing, but its physiological role in vivo remains undefined
17415412Here, we have generated Ews-deficient mice and demonstrated that EWS is required for the completion of B cell development and meiosis
17415412Analysis of Ews(-/-) lymphocytes revealed a cell-autonomous defect in precursor B lymphocyte (pre-B lymphocyte) development
17415412Inactivation of Ews in mouse embryonic fibroblasts resulted in premature cellular senescence, and the mutant animals showed hypersensitivity to ionizing radiation
17415412Finally, we showed that EWS interacts with lamin A/C and that loss of EWS results in a reduced lamin A/C expression
17415412Our findings reveal essential functions for EWS in pre-B cell development and meiosis, with proposed roles in DNA pairing and recombination/repair mechanisms
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