HCSGD entry for EWSR1
1. General information
| Official gene symbol | EWSR1 |
|---|---|
| Entrez ID | 2130 |
| Gene full name | EWS RNA-binding protein 1 |
| Other gene symbols | EWS bK984G1.4 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in Literature mining network.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000166 | Nucleotide binding | IEA | molecular_function |
| GO:0003676 | Nucleic acid binding | IEA | molecular_function |
| GO:0003723 | RNA binding | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005516 | Calmodulin binding | IEA | molecular_function |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0005737 | Cytoplasm | IEA | cellular_component |
| GO:0005886 | Plasma membrane | IEA | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0006355 | Regulation of transcription, DNA-templated | IEA | biological_process |
| GO:0008270 | Zinc ion binding | IEA | molecular_function |
| GO:0042802 | Identical protein binding | IPI | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9798739903 | 0.0885238593 | 0.9999902473 | 0.5644834867 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1764775960 |
| GSE13712_SHEAR | Up | 0.1541773296 |
| GSE13712_STATIC | Down | -0.0651524177 |
| GSE19018 | Down | -0.2645022478 |
| GSE19899_A1 | Down | -0.1833212480 |
| GSE19899_A2 | Down | -0.2363531845 |
| PubMed_21979375_A1 | Down | -1.2462533918 |
| PubMed_21979375_A2 | Down | -0.5173374779 |
| GSE35957 | Down | -0.3022070438 |
| GSE36640 | Down | -0.1645634695 |
| GSE54402 | Down | -0.1375073007 |
| GSE9593 | Down | -0.3209026868 |
| GSE43922 | Up | 0.0043701658 |
| GSE24585 | Up | 0.0758369788 |
| GSE37065 | Up | 0.0396409626 |
| GSE28863_A1 | Up | 0.0186683822 |
| GSE28863_A2 | Up | 0.1538130520 |
| GSE28863_A3 | Down | -0.1282539021 |
| GSE28863_A4 | Up | 0.0032808265 |
| GSE48662 | Down | -0.0508424618 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-877-3p | MIMAT0004950 | MIRT037136 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT040046 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-423-3p | MIMAT0001340 | MIRT042515 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-328-3p | MIMAT0000752 | MIRT043753 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-362-5p | MIMAT0000705 | MIRT044051 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-320a | MIMAT0000510 | MIRT044493 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-149-5p | MIMAT0000450 | MIRT045611 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-23b-3p | MIMAT0000418 | MIRT046333 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-196a-5p | MIMAT0000226 | MIRT048183 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-100-5p | MIMAT0000098 | MIRT048593 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7c-5p | MIMAT0000064 | MIRT051778 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 4 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 21030557 | Ewing sarcoma gene Ews regulates hematopoietic stem cell senescence |
| 21030557 | Here, we demonstrated that endogenous Ewing sarcoma gene (Ews) is indispensable for stem cell quiescence, and that the ablation of Ews promotes the early onset of senescence in hematopoietic stem progenitor cells |
| 21030557 | With its relevance to cancer and possibly aging, EWS is likely to play a significant role in maintaining the functional capacity of stem cells and may provide further insight into the complexity of Ewing sarcoma in the context of stem cells |
| 19133275 | The Ewing sarcoma (EWS) protein is a member of a large family of RNA-binding proteins |
| 19133275 | Chimeric EWS oncoproteins generated by chromosomal translocations between the EWS protein and several transcription factors cause various malignant tumors |
| 19133275 | Due to its multifunctional properties, the EWS protein is involved in such processes as meiotic DNA pairing/recombination, cellular senescence, gene expression, RNA processing and transport, and cell signaling |
| 19133275 | The EWS protein is predominantly located in the nucleus |
| 19133275 | In this study, analysis of the localization of endogenous and fluorescently labeled recombinant EWS protein in different phases of the cell cycle in different cell lines revealed a very dynamic subcellular distribution of the EWS protein |
| 19133275 | In Cos7 and HeLa cells, an association of the EWS protein with the centrosomal compartments was shown |
| 19133275 | As an outlook, the present findings provide an important insight into temporally and spatially regulated functions of the EWS protein and, particularly, into its role in the regulation of the cell cycle and possibly cell differentiation |
| 18271016 | EWS/FLI1 suppresses retinoblastoma protein function and senescence in Ewing's sarcoma cells |
| 18271016 | Ewing's Family Tumors (EFTs) most commonly harbor a specific t(11;22) translocation that generates the EWS/FLI1 fusion protein responsible for malignant transformation |
| 18271016 | Many potential downstream targets of EWS/FLI1 have been identified but a detailed mechanism by which the fusion protein brings about transformation remains unknown |
| 18271016 | In this report, we show that depletion of EWS/FLI1 in Ewing's cell lines results in a senescence phenotype, a marked increase in expression of the G1/S regulatory proteins p27(kip1) and p57(kip2), and a significant decrease in cyclin D1 and CDK2 |
| 18271016 | We also demonstrate for the first time, to our knowledge, that knockdown of EWS/FLI1 leads to hypophosphorylation and functional activation of the retinoblastoma (pRb) family of proteins |
| 18271016 | Together, these results support the role of EWS/LI1 as an inhibitor of cellular senescence and implicate the retinoblastoma family of proteins as key mediators of this inhibition |
| 17415412 | Ewing sarcoma gene EWS is essential for meiosis and B lymphocyte development |
| 17415412 | Ewing sarcoma gene EWS encodes a putative RNA-binding protein with proposed roles in transcription and splicing, but its physiological role in vivo remains undefined |
| 17415412 | Here, we have generated Ews-deficient mice and demonstrated that EWS is required for the completion of B cell development and meiosis |
| 17415412 | Analysis of Ews(-/-) lymphocytes revealed a cell-autonomous defect in precursor B lymphocyte (pre-B lymphocyte) development |
| 17415412 | Inactivation of Ews in mouse embryonic fibroblasts resulted in premature cellular senescence, and the mutant animals showed hypersensitivity to ionizing radiation |
| 17415412 | Finally, we showed that EWS interacts with lamin A/C and that loss of EWS results in a reduced lamin A/C expression |
| 17415412 | Our findings reveal essential functions for EWS in pre-B cell development and meiosis, with proposed roles in DNA pairing and recombination/repair mechanisms |
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