HCSGD entry for AKT2

1. General information

Official gene symbolAKT2
Entrez ID208
Gene full namev-akt murine thymoma viral oncogene homolog 2
Other gene symbolsHIHGHH PKBB PKBBETA PRKBB RAC-BETA
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001934Positive regulation of protein phosphorylationIEA ISSbiological_process
GO:0004672Protein kinase activityIEAmolecular_function
GO:0004674Protein serine/threonine kinase activityIDA IEA TASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIDA IEAmolecular_function
GO:0005634NucleusIDA TAScellular_component
GO:0005829CytosolTAScellular_component
GO:0005886Plasma membraneISS TAScellular_component
GO:0005938Cell cortexIEA ISScellular_component
GO:0005978Glycogen biosynthetic processIEAbiological_process
GO:0006006Glucose metabolic processIEAbiological_process
GO:0006417Regulation of translationIEAbiological_process
GO:0006464Cellular protein modification processTASbiological_process
GO:0006915Apoptotic processIEAbiological_process
GO:0007165Signal transductionTASbiological_process
GO:0008286Insulin receptor signaling pathwayIEA IMP TASbiological_process
GO:0008643Carbohydrate transportIEAbiological_process
GO:0010748Negative regulation of plasma membrane long-chain fatty acid transportIMPbiological_process
GO:0010907Positive regulation of glucose metabolic processIMPbiological_process
GO:0016301Kinase activityTASmolecular_function
GO:0016772Transferase activity, transferring phosphorus-containing groupsIEAmolecular_function
GO:0030334Regulation of cell migrationTASbiological_process
GO:0031340Positive regulation of vesicle fusionIEA ISSbiological_process
GO:0032000Positive regulation of fatty acid beta-oxidationIMPbiological_process
GO:0032287Peripheral nervous system myelin maintenanceIEAbiological_process
GO:0032587Ruffle membraneIEA ISScellular_component
GO:0032859Activation of Ral GTPase activityIEAbiological_process
GO:0032869Cellular response to insulin stimulusIMPbiological_process
GO:0045444Fat cell differentiationTASbiological_process
GO:0045725Positive regulation of glycogen biosynthetic processIMPbiological_process
GO:0046326Positive regulation of glucose importIMPbiological_process
GO:0060644Mammary gland epithelial cell differentiationTASbiological_process
GO:0065002Intracellular protein transmembrane transportIEA ISSbiological_process
GO:0071156Regulation of cell cycle arrestTASbiological_process
GO:0072659Protein localization to plasma membraneIEAbiological_process
GO:0090314Positive regulation of protein targeting to membraneIEA ISSbiological_process
GO:2000147Positive regulation of cell motilityIMPbiological_process
GO:2001275Positive regulation of glucose import in response to insulin stimulusIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.66228800200.57422755210.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0849244229
GSE13712_SHEARUp0.2077060864
GSE13712_STATICUp0.0501716414
GSE19018Up0.1274512836
GSE19899_A1Down-0.0112726505
GSE19899_A2Up0.0164294889
PubMed_21979375_A1Down-0.1179664469
PubMed_21979375_A2Down-0.1617587022
GSE35957Up0.1774367878
GSE36640Down-0.2404478391
GSE54402Up0.0904585084
GSE9593Up0.0079080374
GSE43922Down-0.0459957771
GSE24585Down-0.2197263890
GSE37065Down-0.1609023469
GSE28863_A1Up0.3238048912
GSE28863_A2Up0.1319122398
GSE28863_A3Down-0.0486094345
GSE28863_A4Down-0.0217632406
GSE48662Up0.4829527791

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

N-[(1S)-2-amino-1-phenylethyl]-5-(1H-pyrrolo[2,3-b]pyridin-4-yl)thiophene-2-carboxamideDB07812 -
4-(4-CHLOROPHENYL)-4-[4-(1H-PYRAZOL-4-YL)PHENYL]PIPERIDINEDB07859 -
ISOQUINOLINE-5-SULFONIC ACID (2-(2-(4-CHLOROBENZYLOXY)ETHYLAMINO)ETHYL)AMIDEDB07947 -
(2S)-1-(1H-INDOL-3-YL)-3-{[5-(3-METHYL-1H-INDAZOL-5-YL)PYRIDIN-3-YL]OXY}PROPAN-2-AMINEDB08073 -

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-708-5pMIMAT0004926MIRT006473Luciferase reporter assay//qRT-PCRFunctional MTI22552290
hsa-miR-184MIMAT0000454MIRT000425qRT-PCR//Luciferase reporter assay//Western blotFunctional MTI20409325
hsa-miR-124-3pMIMAT0000422MIRT022768MicroarrayFunctional MTI (Weak)18668037
hsa-miR-21-5pMIMAT0000076MIRT031019Western blot;OtherFunctional MTI20048743
hsa-miR-1296-5pMIMAT0005794MIRT036081CLASHFunctional MTI (Weak)23622248
hsa-miR-877-3pMIMAT0004950MIRT036895CLASHFunctional MTI (Weak)23622248
hsa-miR-744-5pMIMAT0004945MIRT037571CLASHFunctional MTI (Weak)23622248
hsa-miR-423-3pMIMAT0001340MIRT042572CLASHFunctional MTI (Weak)23622248
hsa-miR-149-5pMIMAT0000450MIRT045569CLASHFunctional MTI (Weak)23622248
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    • mirRecord

MicroRNA name

mirBase ID

Target site number

MiRNA mature ID

Test method inter

MiRNA regulation site

Reporter target site

Pubmed ID

hsa-miR-184MIMAT00004541hsa-miR-184{Western blot}{overexpression by miRNA mimics tranfection}20409325
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6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

23469222In one patient, both the Met and AKT2 genes were amplified
234692222% had AKT2 amplification
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