HCSGD entry for AKT2

1. General information

Official gene symbolAKT2
Entrez ID208
Gene full namev-akt murine thymoma viral oncogene homolog 2
Other gene symbolsHIHGHH PKBB PKBBETA PRKBB RAC-BETA
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001934Positive regulation of protein phosphorylationIEA ISSbiological_process
GO:0004672Protein kinase activityIEAmolecular_function
GO:0004674Protein serine/threonine kinase activityIDA IEA TASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIDA IEAmolecular_function
GO:0005634NucleusIDA TAScellular_component
GO:0005829CytosolTAScellular_component
GO:0005886Plasma membraneISS TAScellular_component
GO:0005938Cell cortexIEA ISScellular_component
GO:0005978Glycogen biosynthetic processIEAbiological_process
GO:0006006Glucose metabolic processIEAbiological_process
GO:0006417Regulation of translationIEAbiological_process
GO:0006464Cellular protein modification processTASbiological_process
GO:0006915Apoptotic processIEAbiological_process
GO:0007165Signal transductionTASbiological_process
GO:0008286Insulin receptor signaling pathwayIEA IMP TASbiological_process
GO:0008643Carbohydrate transportIEAbiological_process
GO:0010748Negative regulation of plasma membrane long-chain fatty acid transportIMPbiological_process
GO:0010907Positive regulation of glucose metabolic processIMPbiological_process
GO:0016301Kinase activityTASmolecular_function
GO:0016772Transferase activity, transferring phosphorus-containing groupsIEAmolecular_function
GO:0030334Regulation of cell migrationTASbiological_process
GO:0031340Positive regulation of vesicle fusionIEA ISSbiological_process
GO:0032000Positive regulation of fatty acid beta-oxidationIMPbiological_process
GO:0032287Peripheral nervous system myelin maintenanceIEAbiological_process
GO:0032587Ruffle membraneIEA ISScellular_component
GO:0032859Activation of Ral GTPase activityIEAbiological_process
GO:0032869Cellular response to insulin stimulusIMPbiological_process
GO:0045444Fat cell differentiationTASbiological_process
GO:0045725Positive regulation of glycogen biosynthetic processIMPbiological_process
GO:0046326Positive regulation of glucose importIMPbiological_process
GO:0060644Mammary gland epithelial cell differentiationTASbiological_process
GO:0065002Intracellular protein transmembrane transportIEA ISSbiological_process
GO:0071156Regulation of cell cycle arrestTASbiological_process
GO:0072659Protein localization to plasma membraneIEAbiological_process
GO:0090314Positive regulation of protein targeting to membraneIEA ISSbiological_process
GO:2000147Positive regulation of cell motilityIMPbiological_process
GO:2001275Positive regulation of glucose import in response to insulin stimulusIEAbiological_process
Entries Per Page
Displaying Page of

4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.66228800200.57422755210.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0849244229
GSE13712_SHEARUp0.2077060864
GSE13712_STATICUp0.0501716414
GSE19018Up0.1274512836
GSE19899_A1Down-0.0112726505
GSE19899_A2Up0.0164294889
PubMed_21979375_A1Down-0.1179664469
PubMed_21979375_A2Down-0.1617587022
GSE35957Up0.1774367878
GSE36640Down-0.2404478391
GSE54402Up0.0904585084
GSE9593Up0.0079080374
GSE43922Down-0.0459957771
GSE24585Down-0.2197263890
GSE37065Down-0.1609023469
GSE28863_A1Up0.3238048912
GSE28863_A2Up0.1319122398
GSE28863_A3Down-0.0486094345
GSE28863_A4Down-0.0217632406
GSE48662Up0.4829527791

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

N-[(1S)-2-amino-1-phenylethyl]-5-(1H-pyrrolo[2,3-b]pyridin-4-yl)thiophene-2-carboxamideDB07812 -
4-(4-CHLOROPHENYL)-4-[4-(1H-PYRAZOL-4-YL)PHENYL]PIPERIDINEDB07859 -
ISOQUINOLINE-5-SULFONIC ACID (2-(2-(4-CHLOROBENZYLOXY)ETHYLAMINO)ETHYL)AMIDEDB07947 -
(2S)-1-(1H-INDOL-3-YL)-3-{[5-(3-METHYL-1H-INDAZOL-5-YL)PYRIDIN-3-YL]OXY}PROPAN-2-AMINEDB08073 -

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-708-5pMIMAT0004926MIRT006473Luciferase reporter assay//qRT-PCRFunctional MTI22552290
hsa-miR-184MIMAT0000454MIRT000425qRT-PCR//Luciferase reporter assay//Western blotFunctional MTI20409325
hsa-miR-124-3pMIMAT0000422MIRT022768MicroarrayFunctional MTI (Weak)18668037
hsa-miR-21-5pMIMAT0000076MIRT031019Western blot;OtherFunctional MTI20048743
hsa-miR-1296-5pMIMAT0005794MIRT036081CLASHFunctional MTI (Weak)23622248
hsa-miR-877-3pMIMAT0004950MIRT036895CLASHFunctional MTI (Weak)23622248
hsa-miR-744-5pMIMAT0004945MIRT037571CLASHFunctional MTI (Weak)23622248
hsa-miR-423-3pMIMAT0001340MIRT042572CLASHFunctional MTI (Weak)23622248
hsa-miR-149-5pMIMAT0000450MIRT045569CLASHFunctional MTI (Weak)23622248
Entries Per Page
Displaying Page of
  • mirRecord

MicroRNA name

mirBase ID

Target site number

MiRNA mature ID

Test method inter

MiRNA regulation site

Reporter target site

Pubmed ID

hsa-miR-184MIMAT00004541hsa-miR-184{Western blot}{overexpression by miRNA mimics tranfection}20409325
Entries Per Page
Displaying Page of

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

23469222In one patient, both the Met and AKT2 genes were amplified
234692222% had AKT2 amplification
Entries Per Page
Displaying Page of