HCSGD entry for NR2F6

1. General information

Official gene symbolNR2F6
Entrez ID2063
Gene full namenuclear receptor subfamily 2, group F, member 6
Other gene symbolsEAR-2 EAR2 ERBAL2
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterIDAbiological_process
GO:0003677DNA bindingIEA TASmolecular_function
GO:0003700Sequence-specific DNA binding transcription factor activityIDAmolecular_function
GO:0003707Steroid hormone receptor activityIEAmolecular_function
GO:0004879Ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activityIEA TASmolecular_function
GO:0004887Thyroid hormone receptor activityTASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDA IEAcellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0006367Transcription initiation from RNA polymerase II promoterTASbiological_process
GO:0007165Signal transductionTASbiological_process
GO:0008270Zinc ion bindingIEAmolecular_function
GO:0010467Gene expressionTASbiological_process
GO:0030522Intracellular receptor signaling pathwayTASbiological_process
GO:0043153Entrainment of circadian clock by photoperiodIEAbiological_process
GO:0043565Sequence-specific DNA bindingIDAmolecular_function
GO:0048666Neuron developmentIEAbiological_process
GO:0050965Detection of temperature stimulus involved in sensory perception of painIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.66669838530.43110949430.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0973713465
GSE13712_SHEARDown-0.1492552325
GSE13712_STATICUp0.0807984900
GSE19018Up0.0447567625
GSE19899_A1Down-0.0240813501
GSE19899_A2Up0.5235825747
PubMed_21979375_A1Up0.5675858462
PubMed_21979375_A2Up0.1827532640
GSE35957Down-0.0772979568
GSE36640Down-0.0219997513
GSE54402Down-0.0061490003
GSE9593Down-0.1872319432
GSE43922Up0.3356953315
GSE24585Down-0.2002773996
GSE37065Down-0.3216571460
GSE28863_A1Down-0.0083870651
GSE28863_A2Down-0.1357539028
GSE28863_A3Down-0.1789128961
GSE28863_A4Down-0.0528413246
GSE48662Up0.0261770174

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-346MIMAT0000773MIRT004232MicroarrayFunctional MTI (Weak)16822819
hsa-miR-335-5pMIMAT0000765MIRT018838MicroarrayFunctional MTI (Weak)18185580
hsa-miR-98-5pMIMAT0000096MIRT027803MicroarrayFunctional MTI (Weak)19088304
hsa-miR-30d-5pMIMAT0000245MIRT047809CLASHFunctional MTI (Weak)23622248
hsa-miR-196a-5pMIMAT0000226MIRT048210CLASHFunctional MTI (Weak)23622248
hsa-miR-30a-5pMIMAT0000087MIRT049946CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.