HCSGD entry for EPS8

1. General information

Official gene symbolEPS8
Entrez ID2059
Gene full nameepidermal growth factor receptor pathway substrate 8
Other gene symbols
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0003779Actin bindingIEA ISSmolecular_function
GO:0005070SH3/SH2 adaptor activityTASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005938Cell cortexIEA ISScellular_component
GO:0007165Signal transductionTASbiological_process
GO:0007173Epidermal growth factor receptor signaling pathwayTASbiological_process
GO:0008283Cell proliferationTASbiological_process
GO:0008344Adult locomotory behaviorIEAbiological_process
GO:0008360Regulation of cell shapeIEA ISSbiological_process
GO:0009967Positive regulation of signal transductionTASbiological_process
GO:0010458Exit from mitosisIEA ISSbiological_process
GO:0014069Postsynaptic densityIEAcellular_component
GO:0016301Kinase activityIEAmolecular_function
GO:0016601Rac protein signal transductionIEA ISSbiological_process
GO:0017146N-methyl-D-aspartate selective glutamate receptor complexIEAcellular_component
GO:0030426Growth coneIEAcellular_component
GO:0030832Regulation of actin filament lengthISSbiological_process
GO:0031532Actin cytoskeleton reorganizationIEAbiological_process
GO:0032420StereociliumIEA ISScellular_component
GO:0032587Ruffle membraneIEA ISScellular_component
GO:0036336Dendritic cell migrationIEA ISSbiological_process
GO:0048149Behavioral response to ethanolIEAbiological_process
GO:0048365Rac GTPase bindingIEA ISSmolecular_function
GO:0051016Barbed-end actin filament cappingIEA ISSbiological_process
GO:0051017Actin filament bundle assemblyIEA ISSbiological_process
GO:0051764Actin crosslink formationIEA ISSbiological_process
GO:0070062Extracellular vesicular exosomeIDAcellular_component
GO:0070358Actin polymerization-dependent cell motilityIEA ISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.61668997380.00127661940.99999024730.0683439024

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0470129268
GSE13712_SHEARDown-3.6787993574
GSE13712_STATICDown-1.3648101726
GSE19018Down-0.1632282445
GSE19899_A1Down-2.4858616830
GSE19899_A2Down-1.6519551432
PubMed_21979375_A1Down-2.5772781532
PubMed_21979375_A2Down-2.1909101620
GSE35957Up0.0963727416
GSE36640Down-0.8699146069
GSE54402Down-0.9194869632
GSE9593Up0.3521948812
GSE43922Down-1.0463248694
GSE24585Up0.5883905806
GSE37065Up0.0814017805
GSE28863_A1Up0.4453490115
GSE28863_A2Up0.3572630524
GSE28863_A3Down-0.0667508040
GSE28863_A4Up0.0320984088
GSE48662Up0.5026734515

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-215-5pMIMAT0000272MIRT024889MicroarrayFunctional MTI (Weak)19074876
hsa-miR-192-5pMIMAT0000222MIRT026253MicroarrayFunctional MTI (Weak)19074876
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.