HCSGD entry for EPS8

1. General information

Official gene symbolEPS8
Entrez ID2059
Gene full nameepidermal growth factor receptor pathway substrate 8
Other gene symbols
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0003779Actin bindingIEA ISSmolecular_function
GO:0005070SH3/SH2 adaptor activityTASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005938Cell cortexIEA ISScellular_component
GO:0007165Signal transductionTASbiological_process
GO:0007173Epidermal growth factor receptor signaling pathwayTASbiological_process
GO:0008283Cell proliferationTASbiological_process
GO:0008344Adult locomotory behaviorIEAbiological_process
GO:0008360Regulation of cell shapeIEA ISSbiological_process
GO:0009967Positive regulation of signal transductionTASbiological_process
GO:0010458Exit from mitosisIEA ISSbiological_process
GO:0014069Postsynaptic densityIEAcellular_component
GO:0016301Kinase activityIEAmolecular_function
GO:0016601Rac protein signal transductionIEA ISSbiological_process
GO:0017146N-methyl-D-aspartate selective glutamate receptor complexIEAcellular_component
GO:0030426Growth coneIEAcellular_component
GO:0030832Regulation of actin filament lengthISSbiological_process
GO:0031532Actin cytoskeleton reorganizationIEAbiological_process
GO:0032420StereociliumIEA ISScellular_component
GO:0032587Ruffle membraneIEA ISScellular_component
GO:0036336Dendritic cell migrationIEA ISSbiological_process
GO:0048149Behavioral response to ethanolIEAbiological_process
GO:0048365Rac GTPase bindingIEA ISSmolecular_function
GO:0051016Barbed-end actin filament cappingIEA ISSbiological_process
GO:0051017Actin filament bundle assemblyIEA ISSbiological_process
GO:0051764Actin crosslink formationIEA ISSbiological_process
GO:0070062Extracellular vesicular exosomeIDAcellular_component
GO:0070358Actin polymerization-dependent cell motilityIEA ISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.61668997380.00127661940.99999024730.0683439024

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0470129268
GSE13712_SHEARDown-3.6787993574
GSE13712_STATICDown-1.3648101726
GSE19018Down-0.1632282445
GSE19899_A1Down-2.4858616830
GSE19899_A2Down-1.6519551432
PubMed_21979375_A1Down-2.5772781532
PubMed_21979375_A2Down-2.1909101620
GSE35957Up0.0963727416
GSE36640Down-0.8699146069
GSE54402Down-0.9194869632
GSE9593Up0.3521948812
GSE43922Down-1.0463248694
GSE24585Up0.5883905806
GSE37065Up0.0814017805
GSE28863_A1Up0.4453490115
GSE28863_A2Up0.3572630524
GSE28863_A3Down-0.0667508040
GSE28863_A4Up0.0320984088
GSE48662Up0.5026734515

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-215-5pMIMAT0000272MIRT024889MicroarrayFunctional MTI (Weak)19074876
hsa-miR-192-5pMIMAT0000222MIRT026253MicroarrayFunctional MTI (Weak)19074876
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.