HCSGD entry for EEF2
1. General information
| Official gene symbol | EEF2 |
|---|---|
| Entrez ID | 1938 |
| Gene full name | eukaryotic translation elongation factor 2 |
| Other gene symbols | EEF-2 EF-2 EF2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003746 | Translation elongation factor activity | IEA | molecular_function |
| GO:0003924 | GTPase activity | IEA | molecular_function |
| GO:0005525 | GTP binding | IEA | molecular_function |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0005844 | Polysome | IEA | cellular_component |
| GO:0006412 | Translation | TAS | biological_process |
| GO:0006414 | Translational elongation | TAS | biological_process |
| GO:0010467 | Gene expression | TAS | biological_process |
| GO:0030529 | Ribonucleoprotein complex | IDA | cellular_component |
| GO:0044267 | Cellular protein metabolic process | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.4552572091 | 0.5401789750 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1396833274 |
| GSE13712_SHEAR | Down | -0.2136281645 |
| GSE13712_STATIC | Down | -0.1434290138 |
| GSE19018 | Up | 0.2932684243 |
| GSE19899_A1 | Up | 0.0371465176 |
| GSE19899_A2 | Up | 0.1160123984 |
| PubMed_21979375_A1 | Up | 0.4361742078 |
| PubMed_21979375_A2 | Up | 0.1391795163 |
| GSE35957 | Up | 0.0652336407 |
| GSE36640 | Down | -0.0163737367 |
| GSE54402 | Up | 0.1017970243 |
| GSE9593 | Up | 0.1698285308 |
| GSE43922 | Up | 0.0136776016 |
| GSE24585 | Up | 0.3256721048 |
| GSE37065 | Down | -0.5188323955 |
| GSE28863_A1 | Up | 0.1019408187 |
| GSE28863_A2 | Down | -0.4248674643 |
| GSE28863_A3 | Down | -0.1145554687 |
| GSE28863_A4 | Down | -0.0661701742 |
| GSE48662 | Up | 0.6677146357 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Adenosine-5-Diphosphoribose | DB02059 | EXPT00544 |
| Diphthamide | DB03223 | EXPT01142 |
| Guanosine-5'-Diphosphate | DB04315 | EXPT01573 |
| N~2~,N~2~-DIMETHYL-N~1~-(6-OXO-5,6-DIHYDROPHENANTHRIDIN-2-YL)GLYCINAMIDE | DB08348 | - |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-16-5p | MIMAT0000069 | MIRT031753 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-1229-3p | MIMAT0005584 | MIRT036266 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-296-3p | MIMAT0004679 | MIRT038365 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-99b-3p | MIMAT0004678 | MIRT038532 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92a-1-5p | MIMAT0004507 | MIRT038923 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-769-3p | MIMAT0003887 | MIRT039112 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT039659 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-589-3p | MIMAT0003256 | MIRT040505 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-193b-3p | MIMAT0002819 | MIRT041593 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-484 | MIMAT0002174 | MIRT041660 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-324-3p | MIMAT0000762 | MIRT042856 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-342-3p | MIMAT0000753 | MIRT043730 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-99b-5p | MIMAT0000689 | MIRT044210 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-320a | MIMAT0000510 | MIRT044535 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-186-5p | MIMAT0000456 | MIRT045161 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-185-5p | MIMAT0000455 | MIRT045338 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-222-3p | MIMAT0000279 | MIRT046806 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-10a-5p | MIMAT0000253 | MIRT047726 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-196a-5p | MIMAT0000226 | MIRT048271 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049005 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-30a-5p | MIMAT0000087 | MIRT049963 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-18a-5p | MIMAT0000072 | MIRT050660 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7b-5p | MIMAT0000063 | MIRT051895 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7a-5p | MIMAT0000062 | MIRT052441 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 3 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 27036204 | Using Western blot analysis, we validated the down-regulation of AKR1B1, EEF2, EEF1A1, and HSP90 and the up-regulation of VIM in P6 cells seen in the LC-MS data |
| 12297334 | The involvement of elongation factor-2 (EEF-2), a key-protein of peptide-chain elongation, in the slowing down of protein synthesis during cardiac ageing was addressed |
| 12297334 | EEF-2 was measured in rat heart extracts and isolated rat cardiomyocytes (CM) from newborn and adult rats using sodium-dodecylsulphate polyacrylamide gel electrophoresis after specific labeling with [32P]ADP-ribosylation or immunoblot |
| 12297334 | EEF-2 was considerably reduced in the hearts of adult compared to neonatal rats (P<0 |
| 12297334 | EEF-2 was also significantly decreased in isolated CM from adult versus newborn rats and during prolonged cultivation of neonatal CM |
| 2163888 | Using a diphtheria toxin-mediated assay for measuring the levels of ADP-ribosylatable elongation factor EF-2, we have observed an irreversible decrease of up to 64% in the amount of ADP-ribosylatable EF-2 in normal diploid human fibroblasts MRC-5 undergoing ageing in vitro |
| 2163888 | Reduced levels of ADP-ribosylatable EF-2 could account for the slowing-down of protein synthesis during cell cycle arrest and during cellular ageing in culture |
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