HCSGD entry for EEF2

1. General information

Official gene symbolEEF2
Entrez ID1938
Gene full nameeukaryotic translation elongation factor 2
Other gene symbolsEEF-2 EF-2 EF2
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0003746Translation elongation factor activityIEAmolecular_function
GO:0003924GTPase activityIEAmolecular_function
GO:0005525GTP bindingIEAmolecular_function
GO:0005829CytosolTAScellular_component
GO:0005844PolysomeIEAcellular_component
GO:0006412TranslationTASbiological_process
GO:0006414Translational elongationTASbiological_process
GO:0010467Gene expressionTASbiological_process
GO:0030529Ribonucleoprotein complexIDAcellular_component
GO:0044267Cellular protein metabolic processTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.45525720910.54017897500.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.1396833274
GSE13712_SHEARDown-0.2136281645
GSE13712_STATICDown-0.1434290138
GSE19018Up0.2932684243
GSE19899_A1Up0.0371465176
GSE19899_A2Up0.1160123984
PubMed_21979375_A1Up0.4361742078
PubMed_21979375_A2Up0.1391795163
GSE35957Up0.0652336407
GSE36640Down-0.0163737367
GSE54402Up0.1017970243
GSE9593Up0.1698285308
GSE43922Up0.0136776016
GSE24585Up0.3256721048
GSE37065Down-0.5188323955
GSE28863_A1Up0.1019408187
GSE28863_A2Down-0.4248674643
GSE28863_A3Down-0.1145554687
GSE28863_A4Down-0.0661701742
GSE48662Up0.6677146357

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

Adenosine-5-DiphosphoriboseDB02059 EXPT00544
DiphthamideDB03223 EXPT01142
Guanosine-5'-DiphosphateDB04315 EXPT01573
N~2~,N~2~-DIMETHYL-N~1~-(6-OXO-5,6-DIHYDROPHENANTHRIDIN-2-YL)GLYCINAMIDEDB08348 -

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-16-5pMIMAT0000069MIRT031753ProteomicsFunctional MTI (Weak)18668040
hsa-miR-1229-3pMIMAT0005584MIRT036266CLASHFunctional MTI (Weak)23622248
hsa-miR-296-3pMIMAT0004679MIRT038365CLASHFunctional MTI (Weak)23622248
hsa-miR-99b-3pMIMAT0004678MIRT038532CLASHFunctional MTI (Weak)23622248
hsa-miR-92a-1-5pMIMAT0004507MIRT038923CLASHFunctional MTI (Weak)23622248
hsa-miR-769-3pMIMAT0003887MIRT039112CLASHFunctional MTI (Weak)23622248
hsa-miR-615-3pMIMAT0003283MIRT039659CLASHFunctional MTI (Weak)23622248
hsa-miR-589-3pMIMAT0003256MIRT040505CLASHFunctional MTI (Weak)23622248
hsa-miR-193b-3pMIMAT0002819MIRT041593CLASHFunctional MTI (Weak)23622248
hsa-miR-484MIMAT0002174MIRT041660CLASHFunctional MTI (Weak)23622248
hsa-miR-324-3pMIMAT0000762MIRT042856CLASHFunctional MTI (Weak)23622248
hsa-miR-342-3pMIMAT0000753MIRT043730CLASHFunctional MTI (Weak)23622248
hsa-miR-99b-5pMIMAT0000689MIRT044210CLASHFunctional MTI (Weak)23622248
hsa-miR-320aMIMAT0000510MIRT044535CLASHFunctional MTI (Weak)23622248
hsa-miR-186-5pMIMAT0000456MIRT045161CLASHFunctional MTI (Weak)23622248
hsa-miR-185-5pMIMAT0000455MIRT045338CLASHFunctional MTI (Weak)23622248
hsa-miR-222-3pMIMAT0000279MIRT046806CLASHFunctional MTI (Weak)23622248
hsa-miR-10a-5pMIMAT0000253MIRT047726CLASHFunctional MTI (Weak)23622248
hsa-miR-196a-5pMIMAT0000226MIRT048271CLASHFunctional MTI (Weak)23622248
hsa-miR-92a-3pMIMAT0000092MIRT049005CLASHFunctional MTI (Weak)23622248
hsa-miR-30a-5pMIMAT0000087MIRT049963CLASHFunctional MTI (Weak)23622248
hsa-miR-18a-5pMIMAT0000072MIRT050660CLASHFunctional MTI (Weak)23622248
hsa-let-7b-5pMIMAT0000063MIRT051895CLASHFunctional MTI (Weak)23622248
hsa-let-7a-5pMIMAT0000062MIRT052441CLASHFunctional MTI (Weak)23622248
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 3 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

27036204Using Western blot analysis, we validated the down-regulation of AKR1B1, EEF2, EEF1A1, and HSP90 and the up-regulation of VIM in P6 cells seen in the LC-MS data
12297334The involvement of elongation factor-2 (EEF-2), a key-protein of peptide-chain elongation, in the slowing down of protein synthesis during cardiac ageing was addressed
12297334EEF-2 was measured in rat heart extracts and isolated rat cardiomyocytes (CM) from newborn and adult rats using sodium-dodecylsulphate polyacrylamide gel electrophoresis after specific labeling with [32P]ADP-ribosylation or immunoblot
12297334EEF-2 was considerably reduced in the hearts of adult compared to neonatal rats (P<0
12297334EEF-2 was also significantly decreased in isolated CM from adult versus newborn rats and during prolonged cultivation of neonatal CM
2163888Using a diphtheria toxin-mediated assay for measuring the levels of ADP-ribosylatable elongation factor EF-2, we have observed an irreversible decrease of up to 64% in the amount of ADP-ribosylatable EF-2 in normal diploid human fibroblasts MRC-5 undergoing ageing in vitro
2163888Reduced levels of ADP-ribosylatable EF-2 could account for the slowing-down of protein synthesis during cell cycle arrest and during cellular ageing in culture
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