HCSGD entry for EDNRA

1. General information

Official gene symbolEDNRA
Entrez ID1909
Gene full nameendothelin receptor type A
Other gene symbolsET-A ETA ETA-R ETAR ETRA hET-AR
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001569Patterning of blood vesselsIEAbiological_process
GO:0001666Response to hypoxiaIEAbiological_process
GO:0001701In utero embryonic developmentIEAbiological_process
GO:0001821Histamine secretionIEAbiological_process
GO:0001934Positive regulation of protein phosphorylationIEAbiological_process
GO:0003094Glomerular filtrationIEAbiological_process
GO:0004435Phosphatidylinositol phospholipase C activityTASmolecular_function
GO:0004962Endothelin receptor activityNASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005886Plasma membraneTAScellular_component
GO:0005887Integral component of plasma membraneTAScellular_component
GO:0006939Smooth muscle contractionNASbiological_process
GO:0007165Signal transductionTASbiological_process
GO:0007186G-protein coupled receptor signaling pathwayNASbiological_process
GO:0007190Activation of adenylate cyclase activityTASbiological_process
GO:0007202Activation of phospholipase C activityTASbiological_process
GO:0007204Positive regulation of cytosolic calcium ion concentrationTASbiological_process
GO:0007205Protein kinase C-activating G-protein coupled receptor signaling pathwayIEAbiological_process
GO:0007266Rho protein signal transductionIEAbiological_process
GO:0007507Heart developmentIEAbiological_process
GO:0007568AgingIEAbiological_process
GO:0007585Respiratory gaseous exchangeISSbiological_process
GO:0008152Metabolic processTASbiological_process
GO:0008217Regulation of blood pressureIEAbiological_process
GO:0008283Cell proliferationNASbiological_process
GO:0008284Positive regulation of cell proliferationIEAbiological_process
GO:0014032Neural crest cell developmentIEAbiological_process
GO:0014824Artery smooth muscle contractionIMPbiological_process
GO:0015758Glucose transportISSbiological_process
GO:0019233Sensory perception of painIEAbiological_process
GO:0030315T-tubuleIEAcellular_component
GO:0030818Negative regulation of cAMP biosynthetic processIEAbiological_process
GO:0031965Nuclear membraneIEAcellular_component
GO:0032496Response to lipopolysaccharideIEAbiological_process
GO:0042310VasoconstrictionIMPbiological_process
GO:0042482Positive regulation of odontogenesisIEAbiological_process
GO:0043066Negative regulation of apoptotic processIEAbiological_process
GO:0043084Penile erectionIEAbiological_process
GO:0043278Response to morphineIEAbiological_process
GO:0048144Fibroblast proliferationIEAbiological_process
GO:0048484Enteric nervous system developmentIEAbiological_process
GO:0048659Smooth muscle cell proliferationIEAbiological_process
GO:0050678Regulation of epithelial cell proliferationIEAbiological_process
GO:0050729Positive regulation of inflammatory responseIEAbiological_process
GO:0051281Positive regulation of release of sequestered calcium ion into cytosolIEAbiological_process
GO:0051482Positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathwayIEAbiological_process
GO:0060137Maternal process involved in parturitionIEAbiological_process
GO:0060322Head developmentIEAbiological_process
GO:0070374Positive regulation of ERK1 and ERK2 cascadeIEAbiological_process
GO:0071260Cellular response to mechanical stimulusIEAbiological_process
GO:0090023Positive regulation of neutrophil chemotaxisIEAbiological_process
GO:0090184Positive regulation of kidney developmentIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.95718705220.00029722650.99999024730.0316432000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.7517690011
GSE13712_SHEARDown-0.1198434343
GSE13712_STATICUp0.0214536845
GSE19018Down-0.8079993471
GSE19899_A1Down-1.3157810786
GSE19899_A2Down-2.2252090373
PubMed_21979375_A1Down-2.3769835403
PubMed_21979375_A2Down-1.2885831305
GSE35957Down-0.2492015809
GSE36640Down-2.9603177600
GSE54402Down-0.1357275976
GSE9593Up0.0524689248
GSE43922Down-0.1873001360
GSE24585Down-0.8349308532
GSE37065Up0.8782749977
GSE28863_A1Down-0.6864804900
GSE28863_A2Down-1.3654236117
GSE28863_A3Down-0.0541959084
GSE28863_A4Down-0.3216324714
GSE48662Down-0.1914414307

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

2-HYDROXY-3,5-DIIODOBENZOIC ACIDDB04674 -
DarusentanDB04883 -
PS433540DB05206 -
SPP 301DB05290 -
Actelion-1DB05367 -
SitaxentanDB06268 -
AmbrisentanDB06403 -
MacitentanDB08932 -

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-203aMIMAT0000264MIRT005749Immunofluorescence//In situ hybridization//Luciferase reporter assay//Northern blot//qRT-PCR//Western blotFunctional MTI20827281
hsa-miR-27b-3pMIMAT0000419MIRT005753Immunofluorescence//In situ hybridization//Luciferase reporter assay//Northern blot//qRT-PCR//Western blotFunctional MTI20827281
hsa-miR-224-5pMIMAT0000281MIRT005756Immunofluorescence//In situ hybridization//Luciferase reporter assay//Northern blot//qRT-PCR//Western blotFunctional MTI20827281
hsa-miR-200c-3pMIMAT0000617MIRT007344Luciferase reporter assay//qRT-PCR//Western blotFunctional MTI23272142
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.