HCSGD entry for EDNRA

1. General information

Official gene symbolEDNRA
Entrez ID1909
Gene full nameendothelin receptor type A
Other gene symbolsET-A ETA ETA-R ETAR ETRA hET-AR
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001569Patterning of blood vesselsIEAbiological_process
GO:0001666Response to hypoxiaIEAbiological_process
GO:0001701In utero embryonic developmentIEAbiological_process
GO:0001821Histamine secretionIEAbiological_process
GO:0001934Positive regulation of protein phosphorylationIEAbiological_process
GO:0003094Glomerular filtrationIEAbiological_process
GO:0004435Phosphatidylinositol phospholipase C activityTASmolecular_function
GO:0004962Endothelin receptor activityNASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005886Plasma membraneTAScellular_component
GO:0005887Integral component of plasma membraneTAScellular_component
GO:0006939Smooth muscle contractionNASbiological_process
GO:0007165Signal transductionTASbiological_process
GO:0007186G-protein coupled receptor signaling pathwayNASbiological_process
GO:0007190Activation of adenylate cyclase activityTASbiological_process
GO:0007202Activation of phospholipase C activityTASbiological_process
GO:0007204Positive regulation of cytosolic calcium ion concentrationTASbiological_process
GO:0007205Protein kinase C-activating G-protein coupled receptor signaling pathwayIEAbiological_process
GO:0007266Rho protein signal transductionIEAbiological_process
GO:0007507Heart developmentIEAbiological_process
GO:0007568AgingIEAbiological_process
GO:0007585Respiratory gaseous exchangeISSbiological_process
GO:0008152Metabolic processTASbiological_process
GO:0008217Regulation of blood pressureIEAbiological_process
GO:0008283Cell proliferationNASbiological_process
GO:0008284Positive regulation of cell proliferationIEAbiological_process
GO:0014032Neural crest cell developmentIEAbiological_process
GO:0014824Artery smooth muscle contractionIMPbiological_process
GO:0015758Glucose transportISSbiological_process
GO:0019233Sensory perception of painIEAbiological_process
GO:0030315T-tubuleIEAcellular_component
GO:0030818Negative regulation of cAMP biosynthetic processIEAbiological_process
GO:0031965Nuclear membraneIEAcellular_component
GO:0032496Response to lipopolysaccharideIEAbiological_process
GO:0042310VasoconstrictionIMPbiological_process
GO:0042482Positive regulation of odontogenesisIEAbiological_process
GO:0043066Negative regulation of apoptotic processIEAbiological_process
GO:0043084Penile erectionIEAbiological_process
GO:0043278Response to morphineIEAbiological_process
GO:0048144Fibroblast proliferationIEAbiological_process
GO:0048484Enteric nervous system developmentIEAbiological_process
GO:0048659Smooth muscle cell proliferationIEAbiological_process
GO:0050678Regulation of epithelial cell proliferationIEAbiological_process
GO:0050729Positive regulation of inflammatory responseIEAbiological_process
GO:0051281Positive regulation of release of sequestered calcium ion into cytosolIEAbiological_process
GO:0051482Positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathwayIEAbiological_process
GO:0060137Maternal process involved in parturitionIEAbiological_process
GO:0060322Head developmentIEAbiological_process
GO:0070374Positive regulation of ERK1 and ERK2 cascadeIEAbiological_process
GO:0071260Cellular response to mechanical stimulusIEAbiological_process
GO:0090023Positive regulation of neutrophil chemotaxisIEAbiological_process
GO:0090184Positive regulation of kidney developmentIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.95718705220.00029722650.99999024730.0316432000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.7517690011
GSE13712_SHEARDown-0.1198434343
GSE13712_STATICUp0.0214536845
GSE19018Down-0.8079993471
GSE19899_A1Down-1.3157810786
GSE19899_A2Down-2.2252090373
PubMed_21979375_A1Down-2.3769835403
PubMed_21979375_A2Down-1.2885831305
GSE35957Down-0.2492015809
GSE36640Down-2.9603177600
GSE54402Down-0.1357275976
GSE9593Up0.0524689248
GSE43922Down-0.1873001360
GSE24585Down-0.8349308532
GSE37065Up0.8782749977
GSE28863_A1Down-0.6864804900
GSE28863_A2Down-1.3654236117
GSE28863_A3Down-0.0541959084
GSE28863_A4Down-0.3216324714
GSE48662Down-0.1914414307

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

2-HYDROXY-3,5-DIIODOBENZOIC ACIDDB04674 -
DarusentanDB04883 -
PS433540DB05206 -
SPP 301DB05290 -
Actelion-1DB05367 -
SitaxentanDB06268 -
AmbrisentanDB06403 -
MacitentanDB08932 -

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-203aMIMAT0000264MIRT005749Immunofluorescence//In situ hybridization//Luciferase reporter assay//Northern blot//qRT-PCR//Western blotFunctional MTI20827281
hsa-miR-27b-3pMIMAT0000419MIRT005753Immunofluorescence//In situ hybridization//Luciferase reporter assay//Northern blot//qRT-PCR//Western blotFunctional MTI20827281
hsa-miR-224-5pMIMAT0000281MIRT005756Immunofluorescence//In situ hybridization//Luciferase reporter assay//Northern blot//qRT-PCR//Western blotFunctional MTI20827281
hsa-miR-200c-3pMIMAT0000617MIRT007344Luciferase reporter assay//qRT-PCR//Western blotFunctional MTI23272142
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.