HCSGD entry for LPAR1

1. General information

Official gene symbolLPAR1
Entrez ID1902
Gene full namelysophosphatidic acid receptor 1
Other gene symbolsEDG2 GPR26 Gpcr26 LPA1 Mrec1.3 VZG1 edg-2 rec.1.3 vzg-1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000187Activation of MAPK activityIEAbiological_process
GO:0001965G-protein alpha-subunit bindingIEAmolecular_function
GO:0004930G-protein coupled receptor activityTASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005543Phospholipid bindingIEAmolecular_function
GO:0005737CytoplasmIEAcellular_component
GO:0005886Plasma membraneIEA TAScellular_component
GO:0005887Integral component of plasma membraneTAScellular_component
GO:0007186G-protein coupled receptor signaling pathwayTASbiological_process
GO:0007202Activation of phospholipase C activityTASbiological_process
GO:0007204Positive regulation of cytosolic calcium ion concentrationTASbiological_process
GO:0009986Cell surfaceIDAcellular_component
GO:0010977Negative regulation of neuron projection developmentIEAbiological_process
GO:0016021Integral component of membraneIEAcellular_component
GO:0030139Endocytic vesicleIDAcellular_component
GO:0030165PDZ domain bindingIEAmolecular_function
GO:0032060Bleb assemblyIEAbiological_process
GO:0035025Positive regulation of Rho protein signal transductionIEAbiological_process
GO:0042552MyelinationIEAbiological_process
GO:0043065Positive regulation of apoptotic processIEAbiological_process
GO:0043123Positive regulation of I-kappaB kinase/NF-kappaB signalingIEPbiological_process
GO:0043197Dendritic spineIEAcellular_component
GO:0043198Dendritic shaftIEAcellular_component
GO:0051482Positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathwayIEAbiological_process
GO:0060999Positive regulation of dendritic spine developmentIEAbiological_process
GO:0070915Lysophosphatidic acid receptor activityIEAmolecular_function
GO:0071453Cellular response to oxygen levelsIEAbiological_process
GO:0071673Positive regulation of smooth muscle cell chemotaxisIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.55775652520.00800496560.99999024730.1782256128

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.1280383682
GSE13712_SHEARDown-0.0179771173
GSE13712_STATICUp0.1686926601
GSE19018Up0.1788129681
GSE19899_A1Down-1.7340762682
GSE19899_A2Down-1.5072900237
PubMed_21979375_A1Down-1.7899851080
PubMed_21979375_A2Down-1.5943224952
GSE35957Down-0.0809371316
GSE36640Up0.8183977109
GSE54402Down-0.8749345697
GSE9593Up0.3773167188
GSE43922Down-1.2065735673
GSE24585Down-0.3549099910
GSE37065Up0.3709120345
GSE28863_A1Up0.3685249029
GSE28863_A2Down-0.1965510391
GSE28863_A3Down-0.0723068099
GSE28863_A4Up0.2607240496
GSE48662Down-0.2922926564

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-200c-3pMIMAT0000617MIRT007343Luciferase reporter assay//qRT-PCR//Western blotFunctional MTI23272142
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.