HCSGD entry for LPAR1

1. General information

Official gene symbolLPAR1
Entrez ID1902
Gene full namelysophosphatidic acid receptor 1
Other gene symbolsEDG2 GPR26 Gpcr26 LPA1 Mrec1.3 VZG1 edg-2 rec.1.3 vzg-1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000187Activation of MAPK activityIEAbiological_process
GO:0001965G-protein alpha-subunit bindingIEAmolecular_function
GO:0004930G-protein coupled receptor activityTASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005543Phospholipid bindingIEAmolecular_function
GO:0005737CytoplasmIEAcellular_component
GO:0005886Plasma membraneIEA TAScellular_component
GO:0005887Integral component of plasma membraneTAScellular_component
GO:0007186G-protein coupled receptor signaling pathwayTASbiological_process
GO:0007202Activation of phospholipase C activityTASbiological_process
GO:0007204Positive regulation of cytosolic calcium ion concentrationTASbiological_process
GO:0009986Cell surfaceIDAcellular_component
GO:0010977Negative regulation of neuron projection developmentIEAbiological_process
GO:0016021Integral component of membraneIEAcellular_component
GO:0030139Endocytic vesicleIDAcellular_component
GO:0030165PDZ domain bindingIEAmolecular_function
GO:0032060Bleb assemblyIEAbiological_process
GO:0035025Positive regulation of Rho protein signal transductionIEAbiological_process
GO:0042552MyelinationIEAbiological_process
GO:0043065Positive regulation of apoptotic processIEAbiological_process
GO:0043123Positive regulation of I-kappaB kinase/NF-kappaB signalingIEPbiological_process
GO:0043197Dendritic spineIEAcellular_component
GO:0043198Dendritic shaftIEAcellular_component
GO:0051482Positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathwayIEAbiological_process
GO:0060999Positive regulation of dendritic spine developmentIEAbiological_process
GO:0070915Lysophosphatidic acid receptor activityIEAmolecular_function
GO:0071453Cellular response to oxygen levelsIEAbiological_process
GO:0071673Positive regulation of smooth muscle cell chemotaxisIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.55775652520.00800496560.99999024730.1782256128

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.1280383682
GSE13712_SHEARDown-0.0179771173
GSE13712_STATICUp0.1686926601
GSE19018Up0.1788129681
GSE19899_A1Down-1.7340762682
GSE19899_A2Down-1.5072900237
PubMed_21979375_A1Down-1.7899851080
PubMed_21979375_A2Down-1.5943224952
GSE35957Down-0.0809371316
GSE36640Up0.8183977109
GSE54402Down-0.8749345697
GSE9593Up0.3773167188
GSE43922Down-1.2065735673
GSE24585Down-0.3549099910
GSE37065Up0.3709120345
GSE28863_A1Up0.3685249029
GSE28863_A2Down-0.1965510391
GSE28863_A3Down-0.0723068099
GSE28863_A4Up0.2607240496
GSE48662Down-0.2922926564

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-200c-3pMIMAT0000617MIRT007343Luciferase reporter assay//qRT-PCR//Western blotFunctional MTI23272142
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  • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.