HCSGD entry for NR0B1

1. General information

Official gene symbolNR0B1
Entrez ID190
Gene full namenuclear receptor subfamily 0, group B, member 1
Other gene symbolsAHC AHCH AHX DAX-1 DAX1 DSS GTD HHG NROB1 SRXY2
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterIEAbiological_process
GO:0003677DNA bindingIDAmolecular_function
GO:0003700Sequence-specific DNA binding transcription factor activityIEAmolecular_function
GO:0003707Steroid hormone receptor activityIEAmolecular_function
GO:0003714Transcription corepressor activityIMPmolecular_function
GO:0003723RNA bindingIDAmolecular_function
GO:0004879Ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activityIDA NASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDA IEAcellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0006351Transcription, DNA-templatedIEAbiological_process
GO:0006367Transcription initiation from RNA polymerase II promoterTASbiological_process
GO:0006694Steroid biosynthetic processIDAbiological_process
GO:0007283SpermatogenesisIEAbiological_process
GO:0008104Protein localizationIDAbiological_process
GO:0008134Transcription factor bindingIPImolecular_function
GO:0008406Gonad developmentIMPbiological_process
GO:0008584Male gonad developmentIMPbiological_process
GO:0010467Gene expressionTASbiological_process
GO:0016020MembraneIDAcellular_component
GO:0019904Protein domain specific bindingIPImolecular_function
GO:0021854Hypothalamus developmentNASbiological_process
GO:0021983Pituitary gland developmentNASbiological_process
GO:0030238Male sex determinationIEAbiological_process
GO:0030325Adrenal gland developmentIMPbiological_process
GO:0030522Intracellular receptor signaling pathwayIDA NASbiological_process
GO:0032448DNA hairpin bindingIDAmolecular_function
GO:0033144Negative regulation of intracellular steroid hormone receptor signaling pathwayIDAbiological_process
GO:0033327Leydig cell differentiationIEAbiological_process
GO:0035258Steroid hormone receptor bindingIPImolecular_function
GO:0035902Response to immobilization stressIEAbiological_process
GO:0042788Polysomal ribosomeIDAcellular_component
GO:0042803Protein homodimerization activityIPImolecular_function
GO:0043433Negative regulation of sequence-specific DNA binding transcription factor activityIMPbiological_process
GO:0043565Sequence-specific DNA bindingIDAmolecular_function
GO:0045596Negative regulation of cell differentiationIEAbiological_process
GO:0045892Negative regulation of transcription, DNA-templatedIDA IMPbiological_process
GO:0050682AF-2 domain bindingIPImolecular_function
GO:0060008Sertoli cell differentiationIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.81127993620.65479628810.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.1249299963
GSE13712_SHEARUp0.0071284675
GSE13712_STATICDown-0.0941654902
GSE19018Up0.1773326745
GSE19899_A1Up0.1032460523
GSE19899_A2Down-0.3182839217
PubMed_21979375_A1Down-0.1731023976
PubMed_21979375_A2Up0.0363672863
GSE35957Up0.1552834735
GSE36640Up0.1207636272
GSE54402Up0.0013739682
GSE9593Up0.1060130868
GSE43922Up0.0096106197
GSE24585Up0.0547709465
GSE37065Down-0.0398553592
GSE28863_A1Down-0.2516672409
GSE28863_A2Down-0.2152236613
GSE28863_A3Up0.1339402211
GSE28863_A4Down-0.0208771623
GSE48662Down-0.0106996353

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.