HCSGD entry for NR0B1

1. General information

Official gene symbol	NR0B1
Entrez ID	190
Gene full name	nuclear receptor subfamily 0, group B, member 1
Other gene symbols	AHC AHCH AHX DAX-1 DAX1 DSS GTD HHG NROB1 SRXY2
Links to Entrez Gene	Links to Entrez Gene

2. Neighbors in the network

This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID	GO term	Evidence	Category
GO:0000122	Negative regulation of transcription from RNA polymerase II promoter	IEA	biological_process
GO:0003677	DNA binding	IDA	molecular_function
GO:0003700	Sequence-specific DNA binding transcription factor activity	IEA	molecular_function
GO:0003707	Steroid hormone receptor activity	IEA	molecular_function
GO:0003714	Transcription corepressor activity	IMP	molecular_function
GO:0003723	RNA binding	IDA	molecular_function
GO:0004879	Ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity	IDA NAS	molecular_function
GO:0005515	Protein binding	IPI	molecular_function
GO:0005634	Nucleus	IDA IEA	cellular_component
GO:0005654	Nucleoplasm	TAS	cellular_component
GO:0005737	Cytoplasm	IDA	cellular_component
GO:0006351	Transcription, DNA-templated	IEA	biological_process
GO:0006367	Transcription initiation from RNA polymerase II promoter	TAS	biological_process
GO:0006694	Steroid biosynthetic process	IDA	biological_process
GO:0007283	Spermatogenesis	IEA	biological_process
GO:0008104	Protein localization	IDA	biological_process
GO:0008134	Transcription factor binding	IPI	molecular_function
GO:0008406	Gonad development	IMP	biological_process
GO:0008584	Male gonad development	IMP	biological_process
GO:0010467	Gene expression	TAS	biological_process
GO:0016020	Membrane	IDA	cellular_component
GO:0019904	Protein domain specific binding	IPI	molecular_function
GO:0021854	Hypothalamus development	NAS	biological_process
GO:0021983	Pituitary gland development	NAS	biological_process
GO:0030238	Male sex determination	IEA	biological_process
GO:0030325	Adrenal gland development	IMP	biological_process
GO:0030522	Intracellular receptor signaling pathway	IDA NAS	biological_process
GO:0032448	DNA hairpin binding	IDA	molecular_function
GO:0033144	Negative regulation of intracellular steroid hormone receptor signaling pathway	IDA	biological_process
GO:0033327	Leydig cell differentiation	IEA	biological_process
GO:0035258	Steroid hormone receptor binding	IPI	molecular_function
GO:0035902	Response to immobilization stress	IEA	biological_process
GO:0042788	Polysomal ribosome	IDA	cellular_component
GO:0042803	Protein homodimerization activity	IPI	molecular_function
GO:0043433	Negative regulation of sequence-specific DNA binding transcription factor activity	IMP	biological_process
GO:0043565	Sequence-specific DNA binding	IDA	molecular_function
GO:0045596	Negative regulation of cell differentiation	IEA	biological_process
GO:0045892	Negative regulation of transcription, DNA-templated	IDA IMP	biological_process
GO:0050682	AF-2 domain binding	IPI	molecular_function
GO:0060008	Sertoli cell differentiation	IEA	biological_process

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4. Expression levels in datasets

Meta-analysis result

p-value up	p-value down	FDR up	FDR down
0.8112799362	0.6547962881	0.9999902473	1.0000000000

Individual experiment result
( "-" represent NA in the specific microarray platform )

Data source	Up or down	Log fold change
GSE11954	Up	0.1249299963
GSE13712_SHEAR	Up	0.0071284675
GSE13712_STATIC	Down	-0.0941654902
GSE19018	Up	0.1773326745
GSE19899_A1	Up	0.1032460523
GSE19899_A2	Down	-0.3182839217
PubMed_21979375_A1	Down	-0.1731023976
PubMed_21979375_A2	Up	0.0363672863
GSE35957	Up	0.1552834735
GSE36640	Up	0.1207636272
GSE54402	Up	0.0013739682
GSE9593	Up	0.1060130868
GSE43922	Up	0.0096106197
GSE24585	Up	0.0547709465
GSE37065	Down	-0.0398553592
GSE28863_A1	Down	-0.2516672409
GSE28863_A2	Down	-0.2152236613
GSE28863_A3	Up	0.1339402211
GSE28863_A4	Down	-0.0208771623
GSE48662	Down	-0.0106996353

5. Regulation relationships with compounds/drugs/microRNAs

Compounds

Not regulated by compounds

Drugs

Name	Drug	Accession number

MicroRNAs

mirTarBase

No target information from mirTarBase

mirRecord

No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.

Navigator

1.General information
2.Neighbors in the network
3.Gene Ontology Annotation
4.Expression levels
5.Regulation
6.Text-mining results

HCSGD entry for NR0B1

1. General information

2. Neighbors in the network

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

4. Expression levels in datasets

Meta-analysis result

Individual experiment result ( "-" represent NA in the specific microarray platform )

( "-" represent NA in the specific microarray platform )

5. Regulation relationships with compounds/drugs/microRNAs

Compounds

Drugs

Name

Drug

Accession number

MicroRNAs

mirTarBase

mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.

Navigator

Individual experiment result
( "-" represent NA in the specific microarray platform )