HCSGD entry for ABCA1

1. General information

Official gene symbolABCA1
Entrez ID19
Gene full nameATP-binding cassette, sub-family A (ABC1), member 1
Other gene symbolsABC-1 ABC1 CERP HDLDT1 TGD
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0002790Peptide secretionIEAbiological_process
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIDA IEAmolecular_function
GO:0005543Phospholipid bindingICmolecular_function
GO:0005548Phospholipid transporter activityIDAmolecular_function
GO:0005794Golgi apparatusIEAcellular_component
GO:0005886Plasma membraneTAScellular_component
GO:0005887Integral component of plasma membraneIDAcellular_component
GO:0006497Protein lipidationIEAbiological_process
GO:0006911Phagocytosis, engulfmentIEAbiological_process
GO:0007040Lysosome organizationIDAbiological_process
GO:0007186G-protein coupled receptor signaling pathwayIMPbiological_process
GO:0007584Response to nutrientIEAbiological_process
GO:0008203Cholesterol metabolic processIDAbiological_process
GO:0008509Anion transmembrane transporter activityISSmolecular_function
GO:0009986Cell surfaceIEAcellular_component
GO:0010745Negative regulation of macrophage derived foam cell differentiationTASbiological_process
GO:0010875Positive regulation of cholesterol effluxIEAbiological_process
GO:0010887Negative regulation of cholesterol storageTASbiological_process
GO:0015485Cholesterol bindingICmolecular_function
GO:0016197Endosomal transportIDAbiological_process
GO:0016887ATPase activityIEAmolecular_function
GO:0017127Cholesterol transporter activityIDAmolecular_function
GO:0019905Syntaxin bindingIPImolecular_function
GO:0030139Endocytic vesicleIDAcellular_component
GO:0030819Positive regulation of cAMP biosynthetic processIMPbiological_process
GO:0031267Small GTPase bindingIPImolecular_function
GO:0032367Intracellular cholesterol transportIMPbiological_process
GO:0032489Regulation of Cdc42 protein signal transductionIMPbiological_process
GO:0033344Cholesterol effluxIDA IMPbiological_process
GO:0033700Phospholipid effluxIDA IMPbiological_process
GO:0034185Apolipoprotein bindingIPImolecular_function
GO:0034186Apolipoprotein A-I bindingIPImolecular_function
GO:0034188Apolipoprotein A-I receptor activityIDAmolecular_function
GO:0034220Ion transmembrane transportISSbiological_process
GO:0034380High-density lipoprotein particle assemblyIMPbiological_process
GO:0034616Response to laminar fluid shear stressIEPbiological_process
GO:0038027Apolipoprotein A-I-mediated signaling pathwayIDAbiological_process
GO:0042157Lipoprotein metabolic processTASbiological_process
GO:0042493Response to drugIEAbiological_process
GO:0042632Cholesterol homeostasisIDAbiological_process
GO:0043691Reverse cholesterol transportIMPbiological_process
GO:0044255Cellular lipid metabolic processTASbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0045121Membrane raftIDAcellular_component
GO:0045332Phospholipid translocationIEAbiological_process
GO:0045335Phagocytic vesicleIDAcellular_component
GO:0050702Interleukin-1 beta secretionIMPbiological_process
GO:0055085Transmembrane transportISSbiological_process
GO:0055091Phospholipid homeostasisIMPbiological_process
GO:0055098Response to low-density lipoprotein particleIEPbiological_process
GO:0060155Platelet dense granule organizationIMPbiological_process
GO:0071222Cellular response to lipopolysaccharideIEAbiological_process
GO:0071300Cellular response to retinoic acidIEAbiological_process
GO:0071397Cellular response to cholesterolIEAbiological_process
Entries Per Page
Displaying Page of

4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.00251051630.98392465710.13596563791.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.2292321358
GSE13712_SHEARDown-0.1370000021
GSE13712_STATICUp0.5736902243
GSE19018Up0.1964804962
GSE19899_A1Up0.6728847712
GSE19899_A2Up0.2898117605
PubMed_21979375_A1Up0.8503143860
PubMed_21979375_A2Up0.8703570853
GSE35957Up0.1170440746
GSE36640Up0.0206645192
GSE54402Up0.4419369937
GSE9593Up0.1141915756
GSE43922Up0.7966299542
GSE24585Up0.0595906591
GSE37065Up0.4768320816
GSE28863_A1Up1.1198730374
GSE28863_A2Up1.2356354404
GSE28863_A3Up0.0399970773
GSE28863_A4Down-0.1017617808
GSE48662Up0.2200059644

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

Adenosine triphosphateDB00171 NUTR00017 | EXPT00007
ProbucolDB01599 -

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-33b-5pMIMAT0003301MIRT003670Luciferase reporter assayFunctional MTI20466882
hsa-miR-33a-5pMIMAT0000091MIRT003672Luciferase reporter assayFunctional MTI20466885
hsa-miR-33a-5pMIMAT0000091MIRT003672Luciferase reporter assayFunctional MTI20466882
hsa-miR-33a-5pMIMAT0000091MIRT003672Luciferase reporter assayFunctional MTI20566875
hsa-miR-26a-5pMIMAT0000082MIRT006711Immunoblot//Luciferase reporter assay//qRT-PCRFunctional MTI22673513
hsa-miR-26b-5pMIMAT0000083MIRT006713Immunoblot//Luciferase reporter assay//qRT-PCRFunctional MTI22673513
hsa-miR-26b-5pMIMAT0000083MIRT006713MicroarrayFunctional MTI (Weak)19088304
hsa-miR-19a-3pMIMAT0000073MIRT007121Luciferase reporter assayFunctional MTI23451058
hsa-miR-27a-3pMIMAT0000084MIRT007123Luciferase reporter assayFunctional MTI23451058
Entries Per Page
Displaying Page of
    • mirRecord

MicroRNA name

mirBase ID

Target site number

MiRNA mature ID

Test method inter

MiRNA regulation site

Reporter target site

Pubmed ID

hsa-miR-33b-5pMIMAT00033011hsa-miR-33b{Western blot}{overexpression by miRNA precursor transfection}20466882
hsa-miR-758-3pMIMAT00038791hsa-miR-75821885853
hsa-miR-758-3pMIMAT00038792hsa-miR-75821885853
Entries Per Page
Displaying Page of

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.