HCSGD entry for ABCA1

1. General information

Official gene symbolABCA1
Entrez ID19
Gene full nameATP-binding cassette, sub-family A (ABC1), member 1
Other gene symbolsABC-1 ABC1 CERP HDLDT1 TGD
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in Literature mining network.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0002790Peptide secretionIEAbiological_process
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIDA IEAmolecular_function
GO:0005543Phospholipid bindingICmolecular_function
GO:0005548Phospholipid transporter activityIDAmolecular_function
GO:0005794Golgi apparatusIEAcellular_component
GO:0005886Plasma membraneTAScellular_component
GO:0005887Integral component of plasma membraneIDAcellular_component
GO:0006497Protein lipidationIEAbiological_process
GO:0006911Phagocytosis, engulfmentIEAbiological_process
GO:0007040Lysosome organizationIDAbiological_process
GO:0007186G-protein coupled receptor signaling pathwayIMPbiological_process
GO:0007584Response to nutrientIEAbiological_process
GO:0008203Cholesterol metabolic processIDAbiological_process
GO:0008509Anion transmembrane transporter activityISSmolecular_function
GO:0009986Cell surfaceIEAcellular_component
GO:0010745Negative regulation of macrophage derived foam cell differentiationTASbiological_process
GO:0010875Positive regulation of cholesterol effluxIEAbiological_process
GO:0010887Negative regulation of cholesterol storageTASbiological_process
GO:0015485Cholesterol bindingICmolecular_function
GO:0016197Endosomal transportIDAbiological_process
GO:0016887ATPase activityIEAmolecular_function
GO:0017127Cholesterol transporter activityIDAmolecular_function
GO:0019905Syntaxin bindingIPImolecular_function
GO:0030139Endocytic vesicleIDAcellular_component
GO:0030819Positive regulation of cAMP biosynthetic processIMPbiological_process
GO:0031267Small GTPase bindingIPImolecular_function
GO:0032367Intracellular cholesterol transportIMPbiological_process
GO:0032489Regulation of Cdc42 protein signal transductionIMPbiological_process
GO:0033344Cholesterol effluxIDA IMPbiological_process
GO:0033700Phospholipid effluxIDA IMPbiological_process
GO:0034185Apolipoprotein bindingIPImolecular_function
GO:0034186Apolipoprotein A-I bindingIPImolecular_function
GO:0034188Apolipoprotein A-I receptor activityIDAmolecular_function
GO:0034220Ion transmembrane transportISSbiological_process
GO:0034380High-density lipoprotein particle assemblyIMPbiological_process
GO:0034616Response to laminar fluid shear stressIEPbiological_process
GO:0038027Apolipoprotein A-I-mediated signaling pathwayIDAbiological_process
GO:0042157Lipoprotein metabolic processTASbiological_process
GO:0042493Response to drugIEAbiological_process
GO:0042632Cholesterol homeostasisIDAbiological_process
GO:0043691Reverse cholesterol transportIMPbiological_process
GO:0044255Cellular lipid metabolic processTASbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0045121Membrane raftIDAcellular_component
GO:0045332Phospholipid translocationIEAbiological_process
GO:0045335Phagocytic vesicleIDAcellular_component
GO:0050702Interleukin-1 beta secretionIMPbiological_process
GO:0055085Transmembrane transportISSbiological_process
GO:0055091Phospholipid homeostasisIMPbiological_process
GO:0055098Response to low-density lipoprotein particleIEPbiological_process
GO:0060155Platelet dense granule organizationIMPbiological_process
GO:0071222Cellular response to lipopolysaccharideIEAbiological_process
GO:0071300Cellular response to retinoic acidIEAbiological_process
GO:0071397Cellular response to cholesterolIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.00251051630.98392465710.13596563791.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.2292321358
GSE13712_SHEARDown-0.1370000021
GSE13712_STATICUp0.5736902243
GSE19018Up0.1964804962
GSE19899_A1Up0.6728847712
GSE19899_A2Up0.2898117605
PubMed_21979375_A1Up0.8503143860
PubMed_21979375_A2Up0.8703570853
GSE35957Up0.1170440746
GSE36640Up0.0206645192
GSE54402Up0.4419369937
GSE9593Up0.1141915756
GSE43922Up0.7966299542
GSE24585Up0.0595906591
GSE37065Up0.4768320816
GSE28863_A1Up1.1198730374
GSE28863_A2Up1.2356354404
GSE28863_A3Up0.0399970773
GSE28863_A4Down-0.1017617808
GSE48662Up0.2200059644

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

Adenosine triphosphateDB00171 NUTR00017 | EXPT00007
ProbucolDB01599 -

  • MicroRNAs

  • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-33b-5pMIMAT0003301MIRT003670Luciferase reporter assayFunctional MTI20466882
hsa-miR-33a-5pMIMAT0000091MIRT003672Luciferase reporter assayFunctional MTI20466885
hsa-miR-33a-5pMIMAT0000091MIRT003672Luciferase reporter assayFunctional MTI20466882
hsa-miR-33a-5pMIMAT0000091MIRT003672Luciferase reporter assayFunctional MTI20566875
hsa-miR-26a-5pMIMAT0000082MIRT006711Immunoblot//Luciferase reporter assay//qRT-PCRFunctional MTI22673513
hsa-miR-26b-5pMIMAT0000083MIRT006713Immunoblot//Luciferase reporter assay//qRT-PCRFunctional MTI22673513
hsa-miR-26b-5pMIMAT0000083MIRT006713MicroarrayFunctional MTI (Weak)19088304
hsa-miR-19a-3pMIMAT0000073MIRT007121Luciferase reporter assayFunctional MTI23451058
hsa-miR-27a-3pMIMAT0000084MIRT007123Luciferase reporter assayFunctional MTI23451058
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  • mirRecord

MicroRNA name

mirBase ID

Target site number

MiRNA mature ID

Test method inter

MiRNA regulation site

Reporter target site

Pubmed ID

hsa-miR-33b-5pMIMAT00033011hsa-miR-33b{Western blot}{overexpression by miRNA precursor transfection}20466882
hsa-miR-758-3pMIMAT00038791hsa-miR-75821885853
hsa-miR-758-3pMIMAT00038792hsa-miR-75821885853
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6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.